Search results for "development"
showing 10 items of 26949 documents
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
2013
Journal article Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborat…
Urheilijoiden kaksoisuraan liittyvän tutkimuksen tämänhetkinen tilanne Suomessa
2016
Urheilijan kaksoisura tarkoittaa huippu-urheilun ja opiskelun/ koulutuksen yhdistämistä. Tämä helpottaa urheilijan siirtymistä urheilu-uralta työmarkkinoille. Vaikka kansainvälisen tutkimuksen mukaan useimmat huippu-urheilijat pitävät koulutusta tärkeänä, he useimmiten asettavat urheilu-uran etusijalle yrittäessään sovittaa harjoittelun ja kilpailemisen asettamat vaatimukset koulutusjärjestelmien vaatimuksiin ja rajoituksiin. Tutkimusten mukaan monet lahjakkaat eurooppalaisurheilijat usein joko lopettavat urheilu-uransa panostaakseen koulutukseen ja sitä kautta työllistymiseen tai viivästyttävät tutkinnon hankkimista keskittyäkseen kokonaan urheiluun. Kysymys on otettu osaksi EU:n strategis…
Testing and implementing a new approach to estimating interregional output multipliers using input-output data for South Korean regions
2020
Flegg's location quotient (FLQ) is a useful tool for estimating intraregional output multipliers. This paper uses it as one component when estimating interregional multipliers. Using statistical information criteria and official data for 16 South Korean regions, it is found that the best approach is to combine the FLQ with a simple trade model. The paper explains how the proposed procedure can be implemented for both multiple and individual regions, and also how a region-specific value for the unknown parameter δ in the FLQ formula can be determined. Finally, an illustrative case study of one of the regions is carried out.
Development of vocal performance in 5th grade children - A longitudinal study of choral class singing
2009
The primary aim of the study was to assess the effects of choral class singing on vocal performance in primary school children. In particular, changes of the singing voice in terms of voice range profiles (VRP) and dysphonia severity index (DSI) were measured over the period of one school year. A further aim was to compare the effects of choral singing and regular music curriculum. A total of 50 5th-graders were assigned to two groups. Tuition of the choral singing group (n = 32) entailed a focus on singing in class as well as weekly 30-minute-sessions of special vocal training in small groups. Children in the regular music tuition group (n = 18), which also included singing, were given ext…
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
2009
We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, risk ratio [RR]=1.19; P=2.3×10−7), an association that was replicated in the German AF Network (odds ratio=1.44; P=1.6×10−11). Combining the discovery and replication results, rs2106261 was significantly associated with AF (RR=1.25; P=1.8×10−15).
La politique éolienne et ses effets sur le développement local. Une analyse basée sur le système des acteurs (Loja, Equateur)
2020
La política energética ecuatoriana pretende que las centrales eléctricas contribuyan al desarrollo local en las áreas en las que se implantan. A partir del caso de estudio del Parque Eólico Villonaco (PEV), la pregunta de investigación que se plantea es si el Plan de Desarrollo Territorial Comunitario (PDTC) que se está implementando en la zona de influencia del Parque, está teniendo efectos socio-territoriales positivos. Se utiliza una metodología cualitativa, a partir de entrevistas semiestructuradas a actores clave. Los resultados obtenidos indican que la central eólica ha empezado a tener efectos positivos en el ámbito de los equipamientos educativos, la infraestructura vial, o en el al…
Application of machine learning algorithms in thermal images for an automatic classification of lumbar sympathetic blocks
2023
Purpose There are no previous studies developing machine learning algorithms in the classification of lumbar sympathetic blocks (LSBs) performance using infrared thermography data. The objective was to assess the performance of different machine learning algorithms to classify LSBs carried out in patients diagnosed with lower limbs Complex Regional Pain Syndrome as successful or failed based on the evaluation of thermal predictors. Methods 66 LSBs previously performed and classified by the medical team were evaluated in 24 patients. 11 regions of interest on each plantar foot were selected within the thermal images acquired in the clinical setting. From every region of interest, different t…
Organizational transformation from tailored software production to international Modified-Off-The-Shelf software business model
2002
Vegetation series as a marker of interactions between rural settlements and landscape: new insights from the archaeological record in Western Sicily
2020
[EN] Plant communities are complex and dynamic elements of the landscape, intertwined with both natural factors and human activities. Vegetation series reflect the environmental characteristics of the landscape, but also the anthropic impact, one of the exogenous forces that most profoundly affects the landscape formation process. This paper aims to investigate the interactions between long-term human settlement catchment areas and vegetation series. The case study area of the Sicani Mountains (Central-Western Sicily) proved to be an ideal place to perform GIS-based spatial analysis in order to compare a data set of rural archaeological sites and land units created through the mapping of ve…