Search results for "developmental neuroscience"

Episodic memories: how do the hippocampus and the entorhinal ring attractors cooperate to create them?

2020

AbstractThe brain is capable of registering a constellation of events, encountered only once, as an episodic memory that can last for a lifetime. As evidenced by the clinical case of the patient HM, memories preserving their episodic nature still depend on the hippocampal formation, several years after being created, while semantic memories are thought to reside in neocortical areas. The neurobiological substrate of one-time learning and life-long storing in the brain, that must exist at the cellular and circuit level, is still undiscovered. The breakthrough is delayed by the fact that studies jointly investigating the rodent hippocampus and entorhinal cortex are mostly targeted at understa…

Do we need algebraic-like computations? A reply to Bonatti, Pena, Nespor, and Mehler (2006).

2006

L. L. Bonatti, M. Pena, M. Nespor, and J. Mehler (2006) argued that P. Perruchet, M. D. Tyler, N. Galland, and R. Peereman (2004) confused the notions of segmentation and generalization by ignoring the evidence for generalization in M. Pena, L. L. Bonatti, M. Nespor, and J. Mehler (2002). In this reply, the authors reformulate and complement their initial arguments, showing that their way of dealing with segmentation and generalization is not due to confusion or ignorance but rather to the fact that the tests used in Pena et al. make it likely that neither segmentation nor generalization were captured in their experiments. Finally, the authors address the challenge posed by Pena et al. of a…

P3‐039: Axonal neuritic pathology induces early presynaptic alterations in ps1/APP Alzheimer's mice hippocampus

2011

Loss of neurons in the hippocampus correlates with memory impairment in AD. Significant early reduction in the numerical density of hippocampal SOM interneurons was found in single (APPswe) and double (APPswe/ PS1dE9 and APPswe/TauP301S-G272V) transgenic models based on APP over expression and amyloid production. However, this inhibitory population was unaffected in age-matched single PS1 and tau transgenic mice as well as nontransgenic controls. Whereas SOM neuron loss in APPswe/PS1dE9 was associated to the onset of extracellular amyloid pathology in double APP/ tau mice this loss preceded plaque formation. Conclusions: As in human AD, somatostatin cell loss is a common early pathological …

P2‐077: Identification of potential modifiers of Alzheimer's disease pathology by quantitative mass spectrometry and drosophila genetics

2015

Prevalence of cognitive frailty and associations with other frailty domains in a Spanish community‐dwelling sample

2020

P2‐310: MIDLIFE SELF‐RATED HEALTH AND FITNESS IN RELATION TO WHITE MATTER LESIONS AND GREY MATTER VOLUME 20 YEARS LATER

2014

Midlife self-rated health and fitness in relation to white matter lesions and grey matter volume 20 years later

P2-551: MIGRAINE, COGNITIVE DECLINE, AND DEMENTIA IN OLD AGE: A POPULATION-BASED STUDY

2019

Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia

2013

Abstract Background Physical activity may be beneficial for cognition, but the effect may vary depending on personal characteristics. Methods We investigated the associations between leisure-time physical activity (LTPA) from mid- to late life, the risk of dementia, and the role of body mass index, sex, and APOE in the CAIDE study during 28-year follow-up. Cognitive function of a random subsample was assessed at a mean age of 78.8 years (n = 1511), and dementia/Alzheimer's disease (AD) diagnoses were identified from national registers for the entire target population (n = 3559). Results Moderate (hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.08–1.99) and low levels of midlife LTP…

Exposure to N-ethyl-N-nitrosourea in adult mice alters structural and functional integrity of neurogenic sites.

2011

BackgroundPrevious studies have shown that prenatal exposure to the mutagen N-ethyl-N-nitrosourea (ENU), a N-nitroso compound (NOC) found in the environment, disrupts developmental neurogenesis and alters memory formation. Previously, we showed that postnatal ENU treatment induced lasting deficits in proliferation of neural progenitors in the subventricular zone (SVZ), the main neurogenic region in the adult mouse brain. The present study is aimed to examine, in mice exposed to ENU, both the structural features of adult neurogenic sites, incorporating the dentate gyrus (DG), and the behavioral performance in tasks sensitive to manipulations of adult neurogenesis.Methodology/principal findin…

P3‐315: MID‐LIFE WORK‐RELATED STRESS INCREASES DEMENTIA RISK IN LATE‐LIFE: THE CAIDE 30‐YEAR STUDY

2014

Background: The associations between work-related stress and various health outcomes in mid-life are well documented, yet less is known about the effects on late-life cognitive process and dementia. The current study investigated the associations between work-related stress in mid-life and the development of cognitive impairment and Alzheimer’s disease in late-life. Methods: The data was derived from the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) study; a prospective cohort study. Participants were randomly selected from four independent population-based samples that completed cardiovascular surveys. First baseline examinations occurred when participants were 50 y…