Search results for "diagnostics."
showing 10 items of 190 documents
Demonstration of remote optical measurement configuration that correlates to glucose concentration in blood
2010
An optical approach allowing the extraction and the separation of remote vibration sources has recently been proposed. The approach has also been applied for medical related applications as blood pressure and heart beats monitoring. In this paper we demonstrate its capability to monitor glucose concentration in blood stream. The technique is based on the tracking of temporal changes of reflected secondary speckle produced in human skin (wrist) when being illuminated by a laser beam. A temporal change in skin’s vibration profile generated due to blood pulsation is analyzed for estimating the glucose concentration. Experimental tests that were carried out in order to verify the proposed appro…
Spectroscopic method to study low charge state ion and cold electron population in ECRIS plasma
2018
The results of optical emission spectroscopy experiments probing the cold electron population of a 14 GHz Electron Cyclotron Resonance Ion Source (ECRIS) are reported. The study has been conducted with a high resolution spectrometer and data acquisition setup developed specifically for the diagnostics of weak emission line characteristic to ECRIS plasmas. The optical emission lines of low charge state ions and neutral atoms of neon have been measured and analyzed with the line-ratio method. The aforementioned electron population temperature of the cold electron population (Te < 100 eV) is determined for Maxwell-Boltzmann and Druyvesteyn energy distributions to demonstrate the applicability …
Investigation into the gas mixing effect in ECRIS plasma using Kα and optical diagnostics
2018
Mixing a lighter gas species into the plasma of an ECRIS is known to enhance high charge state production of the heavier gas species. With this investigation, Kα diagnostics, optical emission spectroscopy and the measured charge state distribution of the extracted beam were combined to shed more light on the physics governing this phenomenon. Kα diagnostics data from two ion sources, the JYFL 14 GHz ECRIS and the GTS at iThemba LABS, are presented to gain confidence on the observed trends. The results seem to favor ion cooling as the most likely mechanism responsible for the favorable influence of the gas mixing.Mixing a lighter gas species into the plasma of an ECRIS is known to enhance hi…
Diagnostics for meta-analysis based on generalized linear mixed models
2012
Meta-analysis is the method to combine data coming from multiple studies, with the aim to provide an overall event-risk measure of interest summarizing information coming from the studies. In meta-analysis generalized linear mixed models (GLMM) are particularly used for a number of measures of interest since they allow the true effect size to differ from study to study while accepting binary, discrete as well as continuous response variable. In the present paper some strategies of influence diagnostics based on log-likelihood are suggested and discussed. These are considered for Individual Patient Data, Aggregate Data and their compounding.
Detection of Fusarium Species in Clinical Specimens by Probe-Based Real-Time PCR
2019
The mold Fusarium is a ubiquitous fungus causing plant, animal and human infections. In humans, Fusarium spp. are the major cause of eye infections in patients wearing contact lenses or after local trauma. Systemic infections by Fusarium spp. mainly occur in immunosuppressed patients and can disseminate throughout the human body. Due to high levels of resistance to antifungals a fast identification of the causative agent is an urgent need. By using a probe-based real-time PCR assay specific for the genus Fusarium we analysed several different clinical specimens detecting Fusarium spp. commonly found in clinical samples in Germany. Also, a large collection of lung fluid samples of haematolog…
Development of a Novel Method for Identification of Alaria alata Mesocercariae by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spe…
2021
Alaria (A.) alata mesocercariae (AM) have increasingly appeared as incidental findings during the mandatory inspection of wild boars for Trichinella in many European countries. An Alaria spp.-specific PCR is available for the identification of AM
Toward fast malaria detection by secondary speckle sensing microscopy
2012
Diagnosis of malaria must be rapid, accurate, simple to use, portable and low cost, as suggested by the World Health Organization (WHO). Despite recent efforts, the gold standard remains the light microscopy of a stained blood film. This method can detect low parasitemia and identify different species of Plasmodium. However, it is time consuming, it requires well trained microscopist and good instrumentation to minimize misinterpretation, thus the costs are considerable. Moreover, the equipment cannot be easily transported and installed. In this paper we propose a new technique named "secondary speckle sensing microscopy" ((SM)-M-3) based upon extraction of correlation based statistics of s…
Outlier detection to hierarchical and mixed effects models
2008
Hierarchical and mixed effects models are models where a varying number of coefficients may be random at different levels of the hierarchy. The purpose of outlier analysis for these models is to determine whether an outlying unit at higher level is entirely outlying, or outlying due to effect of one or a few aberrant lower level units. Most works on diagnostics for these complex models have focused on the mixed model rather than on the hierarchical models, obscuring some relevant aspects of the hierarchical model. In this paper we will present an approach to influence analysis and outlier detection for mixed and hierarchical model, focusing on the special structure of nested data that these…
Click chemistry-assisted bioconjugates for hapten immunodiagnostics
2020
Bioorthogonal reactions have revolutionized the way low molecular weight compounds are coupled to biomolecules. Organic chemistry, polymer science, and chemical biology are among the disciplines that are benefited the most from this breakthrough. Despite the reliability of the click chemistry concept for the efficient and chemoselective functionalization of biomacromolecules with haptens at preferred positions, the fact that azide–alkyne cycloaddition reactions originate new chemical moieties as part of the linker may have delayed their application in the immunodiagnostic field. Using the mycotoxin ochratoxin A as a model compound, we herein demonstrate for the first time that bioconjugates…
On the Secondary Discharge of an Atmospheric-Pressure Pulsed DBD in He with Impurities
2008
The secondary discharge was induced at the end of a slow-falling voltage flank, when a semisine monopolar pulse voltage excites the dielectric-barrier discharge. Formation and properties of the secondary discharge with respect to different dielectric materials such as glass, ceramic, and polyethylene theraphtalate were studied. The tunable diode laser absorption spectrometry (at 777.194 nm) was used to analyze the time-space distribution of the density of the atomic oxygen in metastable state (35S2 rarr 35P3) in addition to both discharge voltage and discharge current versus time. The secondary discharge is always formed, and its amplitude, as well as the amplitude of the main discharge, de…