Search results for "differentiation"
showing 10 items of 1605 documents
Do the mobile-rich get richer? Internet use, travelling and social differentiations in Finland
2014
This article investigates the daily travelling practices that are related to mobile-only, fixed-only and combined mobile/fixed use of the Internet, and the social differentiations that are related to these three ways of accessing the Internet. Survey data ( N = 612) collected from Finland in 2011 are analysed. The article shows that mobile-only Internet use is not associated with particularly diverse or frequent daily travelling practices, whereas combined mobile/fixed use is. Mobile-only Internet users are, in fact, in a relatively disadvantaged position – compared with other users, they are more typically unemployed and their household income is lower. The mobility of Internet access as …
Induction of Human P-Glycoprotein in Caco-2 cells: Development of a Highly Sensitive Assay System for P-Glycoprotein-Mediated Drug Transport
2006
The aim of this work is to develop a highly sensitive assay system for P-gp-mediated transport by using two methods, induction of P-gp and short-term culture of Caco-2 cells. To induce P-gp in Caco-2 cells, cells were cultured in vinblastine-containing medium. The mRNA level of P-gp was approximately 7-fold higher in Caco-2 cells cultured with vinblastine (P-gp-induced Caco-2 cells) than in control cells. Western blot analysis showed a significant increase in P-gp expression. After cell differentiation, the mRNA level of P-gp was downregulated, however, P-gp-induced Caco-2 cells still possessed a 5.6-fold higher mRNA level of P-gp compared to control cells. Polarized transport of substrate …
Insights into the compositional evolution of crustal magmatic systems from coupled petrological-geodynamical models
2020
Funding was provided by the VAMOS Research Center, University of Mainz (Germany) and by the ERC Consolidator Grant MAGMA (project #771143). The evolution of crustal magmatic systems is incompletely understood, as most studies are limited either by their temporal or spatial resolution. Exposed plutonic rocks represent the final stage of a long-term evolution punctuated by several magmatic events with different chemistry and generated under different mechanical conditions. Although the final state can be easily described, the nature of each magmatic pulse is more difficult to retrieve. This study presents a new method to investigate the compositional evolution of plutonic systems while consid…
Generalized Lebesgue points for Sobolev functions
2017
In this article, we show that a function $f\in M^{s,p}(X),$ $0<s\leq 1,$ $0<p<1,$ where $X$ is a doubling metric measure space, has generalized Lebesgue points outside a set of $\mathcal{H}^h$-Hausdorff measure zero for a suitable gauge function $h.$
QCD sum rule calculation ofK ℓ3 form factors
1992
We present a combined finite energy sum rule (FESR) and analytic continuation by duality (ACD) calculation of the (neutral)K l3 decay. We confirm the Callan-Treiman relation and investigate the validity of a linear fit for the form factors. Furthermore, we obtain ζ=−0.1...−0.3, consistent with the mean experimental value ζ=−0.1±0.09.
A Constructive Minimal Integral which Includes Lebesgue Integrable Functions and Derivatives
2000
In this paper we provide a minimal constructive integration process of Riemann type which includes the Lebesgue integral and also integrates the derivatives of differentiable functions. We provide a new solution to the classical problem of recovering a function from its derivative by integration, which, unlike the solution provided by Denjoy, Perron and many others, does not possess the generality which is not needed for this purpose.The descriptive version of the problem was treated by A. M. Bruckner, R. J. Fleissner and J. Foran in [2]. Their approach was based on the trivial observation that for the required minimal integral, a function F is the indefinite integral of f if and only if F'…
Networks of Manufacturers and Retailers
2005
We study the endogenous formation of networks between manufacturers of differentiated goods and multi-product retailers who interact in a successive duopoly. Joint consent is needed to establish and/or maintain a costly link between a manufacturer and a retailer. We find that only three distribution networks are stable for particular values of the degree of product differentiation and link costs: (i) the non-exclusive distribution and non-exclusive dealing network in which both retailers distribute both products is stable for intermediate degree of product differentiation and small link costs; (ii) the exclusive distribution and exclusive dealing network in which each retailer distributes a…
Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease
2017
Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors underlying memory defects in Alzheimer’s patients. In this regard, new evidence linking Alzheimer’s disease-related pathology and neuronal stem cells suggests that hippocampal neurogenesis impairment is an important factor underlying these cognitive deficits. However, because of conflicting results, the impact of Aβ pathology on neurogenesis/gliogenesis remains unclear. Here, we investigated the effect of Aβ on neuronal and glial proliferation by using an APP/PS1 transgenic m…
Peroxisome proliferator-activated receptor γ ligands regulate neural stem cell proliferation and differentiation in vitro and in vivo.
2011
Peroxisome proliferator-activated receptor gamma (PPARγ) belongs to a family of ligand-activated nuclear receptors and its ligands are known to control many physiological and pathological situations. Its role in the central nervous system has been under intense analysis during the last years. Here we show a novel function for PPARγ in controlling stem cell expansion in the adult mammalian brain. Adult rats treated with pioglitazone, a specific ligand of PPARγ, had elevated numbers of proliferating progenitor cells in the subventricular zone and the rostral migratory stream. Electron microscopy analysis also showed important changes in the subventricular zone ultrastructure of pioglitazone-t…
Chronic cocaine exposure impairs progenitor proliferation but spares survival and maturation of neural precursors in adult rat dentate gyrus
2006
Recent observations indicate that drugs of abuse, including alcohol and opiates, impair adult neurogenesis in the hippocampus. We have studied in rats the impact of cocaine treatment (20 mg/kg, daily, i.p.) on cell proliferation, survival and maturation following short-term (8-day) and long-term (24-day) exposure. Using 5'-bromo-2-deoxyuridine (BrdU) and Ki-67 as mitotic markers at the end of the drug treatments, we found that both short- and long-term cocaine exposures significantly reduced cell proliferation in the dentate gyrus (DG) of the hippocampus. By labelling mitotic cells with BrdU pulses before or during the early stages of the drug treatment, we determined that long-term cocaine…