Search results for "dilation"
showing 10 items of 304 documents
Mitochondrial oxidative stress and nitrate tolerance – comparison of nitroglycerin and pentaerithrityl tetranitrate in Mn-SOD+/- mice
2006
Abstract Background Chronic therapy with nitroglycerin (GTN) results in a rapid development of nitrate tolerance which is associated with an increased production of reactive oxygen species (ROS). According to recent studies, mitochondrial ROS formation and oxidative inactivation of the organic nitrate bioactivating enzyme mitochondrial aldehyde dehydrogenase (ALDH-2) play an important role for the development of nitrate and cross-tolerance. Methods Tolerance was induced by infusion of wild type (WT) and heterozygous manganese superoxide dismutase mice (Mn-SOD+/-) with ethanolic solution of GTN (12.5 μg/min/kg for 4 d). For comparison, the tolerance-free pentaerithrityl tetranitrate (PETN, 1…
Chronic renal failure: oxidative stress, endothelial dysfunction and wine.
2004
Atherosclerosis development is accelerated in chronic renal failure (CRF) and is the major cause of death in this clinical condition. An increased oxidative stress and an endothelial dysfunction, with their complex interrelationships, are relevant aspects of atherogenesis in CRF patients and might be targets for treatment. Many studies have underlined the cardiovascular protection provided by a moderate wine consumption. This beneficial effect is due to both alcohol and nonalcoholic components of wine including several phenolic molecules such as quercetin and resveratrol. Wine polyphenols have antioxidant properties and favorably influence endothelial function, in particular by stimulating …
Neuropathological Alterations after Smoke Inhalation Injury, with and without Skin Burn
2020
More than 23,000 smoke inhalation injuries are reported in the United States each year. While the pathophysiology of smoke inhalation-induced lung injury is well studied, little is known about the acute effects of smoke inhalation on the central nervous system (CNS). Tragic events, such as those of the nightclub fire in Brazil in 2013, suggest that neurological complications occur following smoke inhalation injury, with the most commonly reported symptoms being a persistent headache, memory loss, and paresthesia. Additionally, one case report described that smoke inhalation alone was associated with progressive cognitive and psychiatric impairments, lasting for years after the initial injur…
Acute Hemodynamic Effects of Nicorandil in Coronary Artery Disease
1992
Nicorandil is a potent vasodilator with antianginal and anti-ischemic properties that acts on both the coronary and the peripheral vascular bed. Because of its dual vasodilatory mechanisms mediated by an increase in cyclic GMP similar to that of nitrates and by a selective increase in the K+ conductance of the smooth muscle cell membrane, nicorandil unloads the right and left ventricles at rest and during exercise. Thus, compared with the classic nitrates, nicorandil is a more balanced vasodilator, i.e., it affects not only the venous capacitance vessels (as predominantly affected by nitrates) but also the arterial resistance vessels. In clinical pharmacologic trials, nicorandil has been ad…
Phosphorylation and activation of endothelial nitric oxide synthase by red fruit (Pandanus conoideus Lam) oil and its fractions
2020
Abstract: Ethnopharmacological relevance Red fruit (Pandanus conoideus Lam) oil (RFO) is utilized by inhabitants of the Papua Island to treat diseases such as infections, cancer, and cardiovascular disease, but the mechanism of action is unknown. Aim of the study We have recently shown that RFO stimulates nitric oxide (NO) production in endothelial cells. The present study was conducted to investigate the molecular mechanism of endothelial NO synthase (eNOS) activation by RFO. Materials and methods NO production by endothelial cells was determined with electron paramagnetic resonance. The vascular function of isolated mouse aorta was examined using a wire myograph system. Phosphorylation of…
Relaxant effects of sodium nitroprusside and NONOates in goat middle cerebral artery: delayed impairment by global ischemia-reperfusion.
1999
Global cerebral ischemia and subsequent reperfusion induce early impairment of the vasodilator responses to hypercapnia and vasoactive substances. Nitric oxide (NO) is involved in the regulation of cerebral blood flow (CBF) in both health and disease. The present study was designed to assess possible changes in the cerebrovascular reactivity to NO donors induced by cerebral ischemia-reperfusion in goats. Female goats (n = 9) were subjected to 20 min global cerebral ischemia under halothane/N2O anesthesia. Sixteen additional goats were sham-operated as a control group. One week later the effects of ischemia-reperfusion on relaxations to NO donors sodium nitroprusside (SNP), diethylamine/NO (…
Halothane inhibits endothelium-dependent relaxation elicited by acetylcholine in human isolated pulmonary arteries.
1997
This study examined whether a clinically relevant concentration of the volatile anaesthetic halothane modifies the endothelium-dependent relaxation produced by acetylcholine (3 nM-10 microM), histamine (1 pM-0.1 microM) and anti-human immunoglobulin E (1:1000) in human isolated pulmonary arteries submaximally precontracted with noradrenaline. An inhibitor of nitric oxide formation, N(G)-nitro-L-arginine (100 microM), attenuated acetylcholine-induced relaxation but failed to inhibit histamine- and anti-human immunoglobulin E-induced relaxation. Indomethacin (2.8 microM, a cyclooxygenase inhibitor) preferentially reduced the relaxation to histamine and anti-human IgE. Halothane (2%) significa…
<title>Reaction-diffusion electrical network for image processing</title>
2006
We consider an experimental setup, modelling the FitzHugh-Nagumo equation without recovery term and composed of a 1D nonlinear electrical network made up of discrete bistable cells, resistively coupled. In the first place, we study the propagation of topological fronts in the continuum limit, then in more discrete case. We propose to apply these results to the domain of signal processing. We show that erosion and dilation of a binary signal, can be obtained. Finally, we extend the study to 2D lattices and show that it can be of great interest in image processing techniques.© (2006) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted fo…
Final report on the CERN muon storage ring including the anomalous magnetic moment and the electric dipole moment of the muon, and a direct test of r…
1978
Abstract A comprehensive description of the muon storage ring and its operation is given, and the final results of the experiment are presented and discussed. The anomalous magnetic moments of positive and negative muons are found to be aμ+ = 1165911(11) × 10−9 and aμ− = 1165937(12) × 10−9 giving an average value for muons of aμ = 1165924(8.5) × 10−9. The electric dipole moments were also measured with the results Dμ+= (8.6 ± 4.5) × 10−9e · cm and Dμ− = (0.8 ± 4.3) × 10−19e · cm. Under the assumption of the CPT theorem these yield a weighted average of Dμ = (3.7 ± 3.4) × 10−19e · cm. Finally the time transformation of special relativity is shown to be valid to (0.8 ± 0.7) × 10−3 at γ ≅ 29.3…
Measurements of relativistic time dilatation for positive and negative muons in a circular orbit
1977
The lifetimes of both positive and negative relativistic (γ = 29.33) muons have been measured in the CERN Muon Storage Ring with the results τ+ = 64.419 (58) µs, τ− = 64.368 (29) µs The value for positive muons is in accordance with special relativity and the measured lifetime at rest: the Einstein time dilation factor agrees with experiment with a fractional error of 2×10−3 at 95% confidence. Assuming special relativity, the mean proper lifetime for μ− is found to be τ0− = 2.1948(10) µs the most accurate value reported to date. The agreement of this value with previously measured values of τ0+ confirms CPT invariance for the weak interaction in muon decay.