Search results for "dilation"
showing 10 items of 304 documents
Initiation of Mono vs. Dual Bronchodilation in the Therapy-Naive COPD Patient in the German Daccord Cohort
2020
Twin paradox in curved spacetime
2022
The twin paradox has played an important role in the history of special relativity (SR). A precise calculation would require the application of the general theory of relativity (GR) but, neglecting the acceleration phases of the traveling twin, even in SR it is possible to find the correct solution without logical contradictions. Nowadays it is well known that the twin thought experiment seems a paradox as a consequence of a naive application of time dilation and the principle of relativity. The twin who goes on space travel is the one who, returning to the twin at rest, finds the aged brother. Continuing in this pedagogical tradition, we want to add a further consideration. In fact, the ex…
Regulation of NOS expression in vascular diseases
2020
Nitric oxide synthases (NOS) are the major sources of nitric oxide (NO), a small bioactive molecule involved in the regulation of many cellular processes. One of the most prominent functions of NO is regulation of vasodilatation and thereby control of blood pressure. Most important for vascular tone is NOS3. Endothelial NOS3-generated NO diffuses into the vascular smooth muscle cells, activates the soluble guanylate cyclase resulting in enhanced cGMP concentrations and smooth muscle cell relaxation. However, more and more evidence exist that also NOS1 and NOS2 contribute to vascular function. We summarize the current knowledge about the regulation of NOS expression in the vasculature by tra…
Organic Nitrate Therapy, Nitrate Tolerance, and Nitrate-Induced Endothelial Dysfunction: Emphasis on Redox Biology and Oxidative Stress
2015
Abstract Organic nitrates, such as nitroglycerin (GTN), isosorbide-5-mononitrate and isosorbide dinitrate, and pentaerithrityl tetranitrate (PETN), when given acutely, have potent vasodilator effects improving symptoms in patients with acute and chronic congestive heart failure, stable coronary artery disease, acute coronary syndromes, or arterial hypertension. The mechanisms underlying vasodilation include the release of •NO or a related compound in response to intracellular bioactivation (for GTN, the mitochondrial aldehyde dehydrogenase [ALDH-2]) and activation of the enzyme, soluble guanylyl cyclase. Increasing cyclic guanosine-3′,-5′-monophosphate (cGMP) levels lead to an activation of…
Red Wine and Cardiovascular Health
2012
There is strong epidemiological evidence that light-to-moderate consumption of alcoholic drinks, but neither zero nor more than moderate intake, reduces mortality from all causes and also diminishes cardiovascular risk.1 The lowest risk for coronary heart disease mortality is seen with 1 to 2 drinks (12.5–25g alcohol) per day. Article, see p 1065 Hypertension is a major risk factor for cardiovascular disease, and there is a clear inverse relationship between light-to-moderate alcohol intake and blood pressure. Thus, the reduced cardiovascular risk associated with moderate consumption of alcoholic drinks may be due, in part, to a reduction in blood pressure. The greatest blood pressure benef…
Could pupil dilation measurements be of any help to sensory analysis?
2011
Could pupil dilation measurements be of any help to sensory analysis?. 29. Pupil colloquium
When the Pd/Pa Is Already Significant: A “Quick and Clean” FFR
2016
The assessment of FFR for a single stenosis may also be rapid and not require hyperemia if the Pd/Pa gradient already reaches significance before the vasodilator is administered. In this case the resting Pd/Pa was 0.45, demonstrating that the stenosis was relevant even before hyperemia was achieved.
Selenium supplementation improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease
2008
Background Selenium is a central determinant of antioxidative glutathione peroxidase 1 (GPx-1) expression and activity. The relevance of selenium supplementation on GPx-1 in coronary artery disease (CAD) needs to be established. We assessed the effect of selenium supplementation on GPx-1 in cell culture and on endothelial function in a prospective clinical trial. Methods Human coronary artery endothelial cells were incubated with 5.78 to 578 nmol/L sodium selenite, Se-methyl-selenocysteine hydrochloride, or seleno-l-methionine. Glutathione peroxidase 1 mRNA and protein expression and activity were measured. Coronary artery disease patients (n = 465) with impaired endothelial function (flow-…
Inflammation and impaired endothelium-dependant vasodilatation in non obese women with gestational diabetes mellitus: preliminary results
2013
International audience; BACKGROUND: To evaluate whether abnormal endothelial function, a common finding in gestational diabetes mellitus (GDM) pregnancies, can be explained by inflammatory cytokines. METHODS: Forearm skin blood flow (FSBF), into response to acetylcholine (Ach) (endothelium-dependent vasodilatation), were measured in 24 pregnant control subjects and 28 gestational diabetes mellitus (GDM) women, in the third trimester of gestation. A fasting glycemic and lipidic panel was obtained, and inflammatory cytokines (TNF-alpha and IL-6) and adiponectin were also determined. RESULTS: FSBF is significantly reduced in GDM group compared with control subjects (344.59 +/- 57.791 vs.176.38…
Nestriktās matemātikas morfoloģijas operatori: teorijas pamati un operatoru realizācija konkrētiem konjuktoru-implikatoru pāriem
2021
Maģistra darbā apskatīti matemātiskās morfoloģijas pamatoperatoru - dilācija, erozija, atvēršana, slēgšana - paplašinājumi nestriktās kopās. Vispārīga nestrikta morfoloģijas operatora definīcija realizēta konkrētiem konjunktoru-implikātoru pāriem. Operatoru realizācijā par konjunktoriem izvēlētas minimuma, reizinājuma un Lukasieviča t-normas un par implikatoriem - tām atbilstošie rezidiji un Klīnī-Dinesa implikācija. Konkrētie konjunktoru-implikatoru pāriem iegūtie operatori ilustrēti ar vizuāliem piemēriem, to realizācijai izstrādāta arī lietojumprogramma. Veikta iegūto rezultātu analīze.