Search results for "donors"
showing 10 items of 242 documents
Diagnostic follow-up of blood donors with indeterminate results to Western Blot for HIV infection in Palermo, Sicily
2002
27,343 blood donors, were tested for HIV infection at the Poli- clinico of Palermo in the period 1999-2001 by using a com- mercial ELISA as screening test and a commercial Western Blot (WB) as confirmatory test. HIV infection was detected in two subjects, whereas five individuals reacted faintly at the screening and tested indeterminate at the confirmatory test showing the presence of only one band for gp41 (four cases) or p24 (one case). A one year follow-up was performed in these patients. All donors but one, spontaneously seroreverted during the follow-up; the only one who persisted as WB inde- terminate, tested also negative for HIV RNA by PCR assay at the end of follow-up. In conclusio…
Orgānu donēšanas aspekti Latvijā
2018
Bakalaura darba tēma: „Orgānu donēšanas aspekti Latvijā”. Tēmas aktualitāti nosaka: orgānu trūkums ir viena no aktuālākajām problēmām, ar ko saskaras transplantācijas nozare, un atšķirība starp piedāvājumu un pieprasījumu turpina pieaugt. Daudziem pacientiem orgānu transplantācija ir vienīgā pieejamā ārstēšanas un dzīvības glābšanas iespēja. Aktuāli kļūst jautājumi par orgānu piedāvājuma palielināšanu, donora un pacienta kvalitatīvu aprūpi un vienlīdzīgu orgānu pieejamību visiem, kam tie nepieciešami. Ir svarīgi saprast informācijas sniegšanas trūkumus sabiedrībai, un kādi aspekti traucē, lai varētu izlemt pozitīvi par orgānu donēšanu. Pētījuma mērķis ir noskaidrot, kādu aspektu vadīti, Lat…
ABO blood groups and Australia antigen
2008
The distribution of ABO blood in two groups of people with Australia antigen was studied (121 blood donors and 128 patients) and in 3,091 controls was investigated. There was a significant excess of A in comparison with o when the two groups were combined, and when the two groups were tested for (A + B): (AB +O) individually and together, both were found to be statistically significant. The results are discussed.
Ability of Kocuria varians LTH 1540 To Degrade Putrescine: Identification and Characterization of a Novel Amine Oxidase.
2015
This work describes the identification and characterization of an amine oxidase from Kocuria varians LTH 1540 (syn. Micrococcus varians) primarily acting on putrescine. Data from MALDI-TOF MS/MS and the identification of Δ(1)-pyrroline as degradation product from putrescine indicate that the enzyme is a flavin-dependent putrescine oxidase (PuO). Properties of partially purified enzyme have been determined. The enzyme oxidizes diamines, putrescine and cadaverine, and, to a lesser extent, polyamines, such as spermidine, but not monoamines. The kinetic constants (Km and Vmax) for the two major substrates were 94 ± 10 μM and 2.3 ± 0.1 μmol/min·mg for putrescine and 75 ± 5 μM and 0.15 ± 0.02 μmo…
Przeszczepy narządowe w okresie epidemii COVID-19
2020
Epidemia COVID-19 zmieniła podejście do kwalifikacji dawców i biorców przeszczepów narządowych. Kwalifikacja następuje po obowiązkowym wykonaniu tomografii komputerowej płuc i testu RT-PCR na obecność wirusa, w wyniku indywidualnej oceny korzyści i ryzyka zakażenia. W bardziej odległym okresie od transplantacji na ciężkość objawów w większym stopniu niż leczenie immunosupresyjne wpływają zaawansowany wiek i współchorobowości. Pierwszym krokiem w redukcji leczenia immunosupresyjnego u biorców przeszczepów narządowych jest odstawienie leku antyproliferacyjnego z pozostawieniem inhibitora kalcyneuryny i steroidów. Terapia immunosupresyjna znamiennie wydłuża czas eliminacji wirusa, ale może ogr…
Rīcības ar cilvēka audiem un orgāniem regulējums Latvijā
2019
Darba tēma ir „Rīcības ar cilvēka audiem un orgāniem regulējums Latvijā”. Šobrīd, kad pasaulē strauji attīstās tāda medicīnas nozare kā cilvēka audu un orgānu transplantācija, pieaug arī cilvēka ķermeņa nelikumīgas izmantošanas gadījumi. Lai arī audu un orgānu nelikumīgas izmantošanas prakse Latvijā ir reti sastopama, arī šiem gadījumiem jāparedz atbilstošs regulējums starptautiskajiem tiesību avotiem. Darba mērķis bija noskaidrot, par kādām nelikumīgām darbībām ar cilvēka audiem un orgāniem ir paredzēta kriminālatbildība Latvijā, kādi ir embriju (fetālo) audu izmantošanas tiesiskie aspekti, un salīdzināt Latvijas tiesisko regulējumu ar starptautisko un ārvalstu regulējumu. Transplantācijas…
Prolactin supplementation to culture medium improves beta-cell survival
2010
OBJECTIVES.: Recent studies demonstrated that prolactin (PRL) has beneficial effects on β cells for islet transplantation. We examined the effect of human recombinant PRL (rhPRL) supplementation to the culture media to determine its potential use in the context of clinical islet transplantation. MATERIALS AND METHODS.: Each human islet isolated from 14 deceased multiorgan donors was cultured in Miami modified media-1 supplemented with or without rhPRL (500 μg/L) for 48 hr. β-Cell survival and proliferation (BrdU and Ki-67) were determined by laser scanning cytometry. The cytoprotective effects of rhPRL against noxious stimuli were assessed by flow cytometry (tetramethylrhodamine ethyl ester…
Multivalent N-donor ligands for the construction of coordination polymers and coordination polymer gels
2018
This work describes the synthesis and characterisation of several multivalent N-donor ligands and their coordination compounds and the use of these ligands in the construction of coordination polymers and coordination polymer gels. The project can be divided into two parts. The first part of the research is focused on the coordination chemistry of ring-substituted biimidazoles in acidic media. The dependence of the formation of ion pairs and zwitterionic, especially zinc and copper containing coordination compounds on the pH of the reaction medium and ring-substituents of the ligand were examined. The second part of the study deals with the preparation of Ag, Zn and Cu coordination polymers…
Prolonging in utero-like oxygenation after birth diminishes oxidative stress in the lung and brain of mice pups☆
2013
Background Fetal-to-neonatal transition is associated with oxidative stress. In preterm infants, immaturity of the antioxidant system favours supplemental oxygen-derived morbidity and mortality. Objectives To assess if prolonging in utero-like oxygenation during the fetal-to-neonatal transition limits oxidative stress in the lung and brain, improving postnatal adaptation of mice pups. Material and methods Inspiratory oxygen fraction (FiO2) in pregnant mice was reduced from 21% (room air) to 14% (hypoxia) 8–12 h prior to delivery and reset to 21% 6–8 h after birth. The control group was kept at 21% during the procedure. Reduced (GSH) and oxidized (GSSG) glutathione and its precursors [γ-glut…
Uztura nozīme asins un asins komponentu donoriem. Hilozes profilakse.
2015
Bakalaura darba „Uztura nozīme asins un asins komponentu donoriem. Hilozes profilakse” mērķis ir noskaidrot uztura nozīmi asins donoriem hilozes profilaksei. Pētījums veikts X asins sagatavošanas nodaļa.. Pētījumā respondenti: 9 plazmas donori, ar 8 no tiem tika runāts 2 reizes ar 2 nedēļu intervālu, ar 1 respondentu tika runāts 1 reizi. Pētījumā jautājumi: Kā donora uzturs ietekmē asins un asins komponentu hilozi? Vai donori ir gatavi mainīt savus uztura ieradumus lai uzlabotu asins kvalitāti?. Pielietota kvalitatīva pētījuma metode- kontentanalize. Datu pārstrāde– Microsoft Office Word 2007. Iegūtie rezultāti parāda, ka donora uzturs ietekmē asins un asins komponentu hilozi un mainoties d…