Search results for "e learning"
showing 10 items of 2703 documents
ADME Prediction with KNIME: Development and Validation of a Publicly Available Workflow for the Prediction of Human Oral Bioavailability.
2020
In silico prediction of human oral bioavailability is a relevant tool for the selection of potential drug candidates and for the rejection of those molecules with less probability of success during the early stages of drug discovery and development. However, the high variability and complexity of oral bioavailability and the limited experimental data in the public domain have mainly restricted the development of reliable in silico models to predict this property from the chemical structure. In this study we present a KNIME automated workflow to predict human oral bioavailability of new drug and drug-like molecules based on five machine learning approaches combined into an ensemble model. Th…
Advanced computation in cardiovascular physiology: New challenges and opportunities
2021
Recent developments in computational physiology have successfully exploited advanced signal processing and artificial intelligence tools for predicting or uncovering characteristic features of physiological and pathological states in humans. While these advanced tools have demonstrated excellent diagnostic capabilities, the high complexity of these computational 'black boxes’ may severely limit scientific inference, especially in terms of biological insight about both physiology and pathological aberrations. This theme issue highlights current challenges and opportunities of advanced computational tools for processing dynamical data reflecting autonomic nervous system dynamics, with a speci…
Multi-agent Reinforcement Learning for Simulating Pedestrian Navigation
2012
In this paper we introduce a Multi-agent system that uses Reinforcement Learning (RL) techniques to learn local navigational behaviors to simulate virtual pedestrian groups. The aim of the paper is to study empirically the validity of RL to learn agent-based navigation controllers and their transfer capabilities when they are used in simulation environments with a higher number of agents than in the learned scenario. Two RL algorithms which use Vector Quantization (VQ) as the generalization method for the space state are presented. Both strategies are focused on obtaining a good vector quantizier that generalizes adequately the state space of the agents. We empirically state the convergence…
Computational issues in fitting joint frailty models for recurrent events with an associated terminal event.
2020
Abstract Background and objective: Joint frailty regression models are intended for the analysis of recurrent event times in the presence of informative drop-outs. They have been proposed for clinical trials to estimate the effect of some treatment on the rate of recurrent heart failure hospitalisations in the presence of drop-outs due to cardiovascular death. Whereas a R-software-package for fitting joint frailty models is available, some technical issues have to be solved in order to use SASⓇ 1 software, which is required in the regulatory environment of clinical trials. Methods: First, we demonstrate how to solve these issues by deriving proper likelihood-decompositions, in particular fo…
A framework for modelling the biomechanical behaviour of the human liver during breathing in real time using machine learning
2017
Progress in biomechanical modelling of human soft tissue is the basis for the development of new clinical applications capable of improving the diagnosis and treatment of some diseases (e.g. cancer), as well as the surgical planning and guidance of some interventions. The finite element method (FEM) is one of the most popular techniques used to predict the deformation of the human soft tissue due to its high accuracy. However, FEM has an associated high computational cost, which makes it difficult its integration in real-time computer-aided surgery systems. An alternative for simulating the mechanical behaviour of human organs in real time comes from the use of machine learning (ML) techniq…
Bag-of-word based brand recognition using Markov Clustering Algorithm for codebook generation
2015
International audience; In order to address the issue of counterfeiting online, it is necessary to use automatic tools that analyze the large amount of information available over the Internet. Analysis methods that extract information about the content of the images are very promising for this purpose. In this paper, a method that automatically extract the brand of objects in images is proposed. The method does not explicitly search for text or logos. This information is implicitly included in the Bag-of-Words representation. In the Bag-of-Words paradigm, visual features are clustered to create the visual words. Despite its shortcomings, k-means is the most widely used algorithm. With k-mea…
A Comparison of Advanced Regression Algorithms for Quantifying Urban Land Cover
2014
Quantitative methods for mapping sub-pixel land cover fractions are gaining increasing attention, particularly with regard to upcoming hyperspectral satellite missions. We evaluated five advanced regression algorithms combined with synthetically mixed training data for quantifying urban land cover from HyMap data at 3.6 and 9 m spatial resolution. Methods included support vector regression (SVR), kernel ridge regression (KRR), artificial neural networks (NN), random forest regression (RFR) and partial least squares regression (PLSR). Our experiments demonstrate that both kernel methods SVR and KRR yield high accuracies for mapping complex urban surface types, i.e., rooftops, pavements, gras…
Relation between adaptive learning actions and profiles of MOOCs users
2016
The overcrowding and the heterogeneity of participants' profiles in a Massive Open Online Course (MOOC) are some of the main causes for a high dropout rate. International reports and research works points out the personalized learning as an important way to improve learning in any educational context. The information and communication technologies help to address adaptive technics in education through online courses. The specific characteristics of MOOCs point to the need to implement adaptive methodologies in MOOCs to increase the completion rates. This work presents a statistical analysis to find out in what aspects the condition of adaptivity, defined by the construct, is a preference of…
Adaptive Population Importance Samplers: A General Perspective
2016
Importance sampling (IS) is a well-known Monte Carlo method, widely used to approximate a distribution of interest using a random measure composed of a set of weighted samples generated from another proposal density. Since the performance of the algorithm depends on the mismatch between the target and the proposal densities, a set of proposals is often iteratively adapted in order to reduce the variance of the resulting estimator. In this paper, we review several well-known adaptive population importance samplers, providing a unified common framework and classifying them according to the nature of their estimation and adaptive procedures. Furthermore, we interpret the underlying motivation …
Time in Associative Learning: A Review on Temporal Maps
2021
Ability to recall the timing of events is a crucial aspect of associative learning. Yet, traditional theories of associative learning have often overlooked the role of time in learning association and shaping the behavioral outcome. They address temporal learning as an independent and parallel process. Temporal Coding Hypothesis is an attempt to bringing together the associative and non-associative aspects of learning. This account proposes temporal maps, a representation that encodes several aspects of a learned association, but attach considerable importance to the temporal aspect. A temporal map helps an agent to make inferences about missing information by applying an integration mechan…