Search results for "efficiency"

Estimation of interfacial fracture toughness based on progressive edge delamination of a thin transparent coating on a polymer substrate

2010

Evaluation of interfacial toughness of sub-micron-thickness layers deposited on a ductile substrate is a challenging task which has motivated different experimental approaches Fragmentation testing was used in the present study as a means of interface characterization of a silicon-nitride-coated polyimide substrate. During the test, after an initial rapid segmentation-cracking phase, the coating fragments developed edge delaminations which propagated in a stable manner with further increase in the applied strain The debonding process was modelled by the finite element method Incorporating a cohesive zone at the front of the interfacial crack The edge cracks were found to be dominated by mod…

A Trans-amplifying RNA Vaccine Strategy for Induction of Potent Protective Immunity

2019

Here, we present a potent RNA vaccine approach based on a novel bipartite vector system using trans-amplifying RNA (taRNA). The vector cassette encoding the vaccine antigen originates from an alphaviral self-amplifying RNA (saRNA), from which the replicase was deleted to form a transreplicon. Replicase activity is provided in trans by a second molecule, either by a standard saRNA or an optimized non-replicating mRNA (nrRNA). The latter delivered 10- to 100-fold higher transreplicon expression than the former. Moreover, expression driven by the nrRNA-encoded replicase in the taRNA system was as efficient as in a conventional monopartite saRNA system. We show that the superiority of nrRNA- ov…

Contribution of polyadenylate sequences to the translational efficiency of globin messenger RNAs

1987

mRNAs from reticulocyte polysomes were fractionated by chromatography on poly(U)-Sepharose and thermal elution. The molar ratio of alpha- to beta-globin mRNA was found to be 2:1 and 1:1 respectively in short- and long-poly(A) size classes. Translational analyses indicated that the globin mRNAs containing long poly(A) tracts (with a mean length of about 70 nucleotides) directed protein synthesis with higher rates than did mRNA containing short poly(A) tracts (15-35 nucleotides). Experiments performed with sub-saturating mRNA concentrations showed that the digestion with RNAase H induced a decrease in the translational capacity of both globin mRNAs and an increase in the alpha- to beta-globin…

Non-regular network performance comparison between HSDPA and LTE

2010

In this paper we study and benchmark the performance of 3rd Generation Partnership Project (3GPP) High Speed Downlink Packet Access (HSDPA) and 3GPP Long Term Evolution (LTE) Downlink with constant bit rate type traffic. In addition a non-regular simulation scenario is considered using realistic propagation data and base station positions related to Tokyo city downtown area. HSDPA was introduced in 3GPP Release 5 and in further releases the technology has been improved with e.g. receive and transmit diversity technologies and support for higher order modulation schemes. LTE was introduced in 3GPP Release 8 with completely new physical layer and improved Radio Resource Management (RRM) funct…

Push‐Pull Design of Bis(tridentate) Ruthenium(II) Polypyridine Chromophores as Deep Red Light Emitters in Light‐Emitting Electrochemical Cells

2013

Light-emitting electrochemical cells (LECs) with a simple device structure were prepared by using heteroleptic bis(tridentate) ruthenium(II) complexes [1](PF6)(2)-[3](PF6)(2) as emitters. The push-pull substitution shifts the emission energy to low energy, into the NIR region. The devices emit deep red light up to a maximum emission wavelength of 755 nm [CIE (International Commission on Illumination) coordinates: x = 0.731, y = 0.269 for [3](PF6)(2)], which, to the best of our knowledge, is the lowest emission energy for LECs containing bis(tridentate) ruthenium(II) complexes. A device structure of ITO/PEDOT:PSS/ruthenium(II) complex/Ag was used, and the thickness of the emitting layer was …

Nitrogen efficiency in wheat as affected by crop rotation, tillage and N fertilization.

2009

Important Aspects of Biowastes Collection and Composting in Nigeria

2002

Many of the areas that generate organic waste that could be biotreated are inaccessible for collection because of the lack of accessible roads, poverty of the residents and general neglect of such places by the government authorities. In Lagos in 1999 it was observed that trucks collecting wastes cannot get into 40% of the inner part of the municipalities because the roads are too narrow or blocked by illegal structures. So one-third of the population received no refuse collection service. There is very little knowledge about the treatment of biowaste and the activities are very low. The laws and regulations governing the management of waste, in general, are weak and inefficient. An importa…

Essentials of Common Industrial Policy

2021

A set of sixteen principles of modern industrial policy is derived from the literature for application to entire regions. Such policy strives to create industrial commons and to rectify market failures which cannot reasonably be expected to self-correct over time. This chapter creates a workable typology of genuine regional industries, distinguishing two main types: Type I is the outcome of targeted selection and Type II of broad investment promotion. A ‘dual core’ of both types is appropriate to most African industrial ecosystems. The chapter goes on to clarify the distinction between regional production networks and stand-alone ‘lighthouses’. The incentive system for regional industries i…

Trigger and aperture of the surface detector array of the Pierre Auger Observatory

2010

The surface detector array of the Pierre Auger Observatory consists of 1600 water-Cherenkov detectors, for the study of extensive airshowers (EAS) generated by ultra-high-energy cosmic rays. We describe the trigger hierarchy, from the identification of candidates howers at the level of a single detector, amongst a large background (mainly random single cosmic ray muons), up to the selection of real events and the rejection of random coincidences. Such trigger makes the surface detector array fully efficient for the detection of EAS with energy above 3 x 1018 eV, for all zenith angles between 03 and 603, independently of the position of the impact point and of the mass of the primary particl…

Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells.

2006

AbstractAdoptive transfer of dendritic cells (DCs) transfected with in vitro–transcribed, RNA-encoding, tumor-associated antigens has recently entered clinical testing as a promising approach for cancer immunotherapy. However, pharmacokinetic exploration of RNA as a potential drug compound and a key aspect of clinical development is still pending. While investigating the impact of different structural modifications of RNA molecules on the kinetics of the encoded protein in DCs, we identified components located 3′ of the coding region that contributed to a higher transcript stability and translational efficiency. With the use of quantitative reverse transcription–polymerase chain reaction (R…