Search results for "eosin"

showing 10 items of 275 documents

Die Bestimmung von Wachstumshormon (HGH) als Diagnosticum bei chromophoben und eosinophilen Adenomen der Hypophyse

1971

Der Wert der radioimmunologischen Bestimmung von Wachstumshormon (HGH) in der praoperativen Diagnostik von chromophoben und eosinophilen Adenomen der Hypophyse wird an 27 Fallen demonstriert. Als Funktionstest wird die Insulin-induzierte Hypoglykamie angewandt. Eine einfache Maszahl (FHGH) zur Auswertung der Ergebnisse wird vorgeschlagen, die durch Integration der Flachen unter den HGH-Kurven erhalten wird. Als indirekte Testverfahren zur Uberprufung der Hypophysenfunktion dienen ein Metopiron- und ein ACTH-Test.

Gynecologymedicine.medical_specialtybusiness.industryHuman growth hormoneGeneral MedicineChromophobe cellEosinophilmedicine.anatomical_structureDrug DiscoverymedicineMolecular MedicineDifferential diagnosisbusinessGenetics (clinical)Klinische Wochenschrift
researchProduct

Eosinophilic ulcer tongue: a diagnostic challenge controversial pathogenesis

2013

La úlcera eosinofílica, también conocida como granuloma ulcerativo traumático con eosinofilia estromal, es una infrecuente y benigna lesión ulcerativa de la mucosa oral que presenta una evolución persistente, planteando a menudo diferentes diagnósticos clínicos diferenciales. Su diagnóstico se establece solo a partir del estudio histopatológico, si bien su morfología presenta a menudo características que pueden sugerir al patólogo la existencia de un proceso linfoproliferativo, traduciendo una patogénesis lesional controvertida todavía no bien aclarada. Comunicamos una observación clínico-patológica de úlcera eosinofílica afectando a una mujer de 76 años de edad. La lesión, de 2,5 cm de diá…

HistopatologíaTraumatic ulcerative granuloma with stromal eosinophiliaÚlcera eosinofílicaHistopathologyGranuloma ulcerativo traumático con eosinofília estromalImmunohistochemistryInmunohistoquímiaEosinophilic ulcer
researchProduct

Successful treatment with imatinib of lymphomatoid papulosis associated with myeloproliferative hypereosinophilic syndrome with PDGFRA rearrangement

2020

Hypereosinophilic syndromebusiness.industryCancer researchmedicineImatinibDermatologyPDGFRALymphomatoid papulosismedicine.diseasebusinessmedicine.drugJDDG: Journal der Deutschen Dermatologischen Gesellschaft
researchProduct

Alpha interferon for hypereosinophilic syndrome

1994

Hypereosinophilic syndromebusiness.industryImmunologymedicineAlpha interferonHematologymedicine.diseasebusinessAmerican Journal of Hematology
researchProduct

Cluster analysis of clinical data reveals three pediatric eosinophilic gastrointestinal disorder phenotypes

2022

Primary eosinophilic gastrointestinal disorders (EGIDs) are a spectrum of emerging inflammatory diseases, which may involve any part of the gastrointestinal (GI) tract and lead to a pathological eosinophilic mucosal infiltration.1,2 Based on the anatomical site of the eosinophil inflammation, EGIDs are classified into eosinophilic esophagitis (EoE) and nonesophageal EGIDs.This study aimed to characterize EGIDs heterogeneity by performing cluster analysis on a cohort of children and adolescents followed at the Pediatric Center for Eosinophilic Gastrointestinal Disorders (CPED) in Pavia, Italy, using an extensive pediatric primary care database from our University Hospital

ImmunologyphenotypesCluster analysis eosinophilic gastrointestinal disorder children phenotypesEnteritisEGIDs cluster analysisPhenotypepediatricCluster analysiseosinophilic gastrointestinal disorderchildrenGastritisEosinophiliaPediatrics Perinatology and Child HealthHumansImmunology and AllergyChild
researchProduct

In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats

2019

Graphical abstract

In situPO Propylene oxideIV IntravenousP338 Poloxamer 338lcsh:RS1-441Pharmaceutical Sciencechemistry.chemical_compoundn Sample sizeSD Standard deviationIM Intramuscularchemistry.chemical_classificationC0 Analyte plasma concentration at time zeroDoE Design of experimentsUV UltravioletPharmacology. TherapyK2.EDTA Potassium ethylenediaminetetraacetic acidLC–MS/MS Liquid chromatography-tandem mass spectrometryH&E Hematoxylin and eosintmax Sampling time to reach the maximum observed analyte plasma concentrationIn situ forming gelsCMC Critical micellar concentrationCmax Maximum observed analyte plasma concentrationIntramuscular injectionDN Dose normalizedGPT Gel point temperaturePLGA Poly-(DL-lactic-co-glycolic acid)TFA Trifluoroacetic acidCAN AcetonitrileATP Adenosine 5′ triphosphateSalt (chemistry)Polyethylene glycolPoloxamerArticlelcsh:Pharmacy and materia medicaPharmacokineticsIn vivoUHPLC Ultra-high performance liquid chromatographyPharmacokineticsAUClast Area under the analyte concentration versus time curve from time zero to the time of the last measurable (non-below quantification level) concentrationEO Ethylene oxideNMP N-methyl-2-pyrrolidoneComputingMethodologies_COMPUTERGRAPHICSAUC∞ Area under the analyte concentration vs time curve from time zero to infinite timeP407 Poloxamer 407In vitro releasePoloxamerCMT Critical micellar temperatureGel erosionIn vitrot1/2 Apparent terminal elimination half-lifechemistryMDR-TB Multi-drug resistant tuberculosisAUC80h Area under the analyte concentration versus time curve from time zero to 80 htlast Sampling time until the last measurable (non-below quantification level) analyte plasma concentrationMRM Multiple reaction monitoringNuclear chemistrySustained releaseInternational Journal of Pharmaceutics: X
researchProduct

II - V metakarpālā kaula distālās metaepifīzes ekstraartikulāru lūzumu optimāla osteosintēze ar stieplēm

2019

DARBA AKTUALITĀTE: MKK lūzumi ir biežāk sastopamie rokas lūzumi populācijā – tie sastāda gandrīz pusi no visiem rokas lūzumiem, vairumā gadījumu skar labo roku un jaunus cilvēkus darbaspēju vecumā. Metakarpālo kaulu lūzumu osteosintēzes izpildījums ir viens no faktoriem, kas nosaka operētās rokas funkcionālos rezultātus, tādēļ būtiski, ārstējot pacientus, izvērtēt un izvēlēties optimālāko operācijas metodi jeb to, kura nodrošina pēc iespējas labākus pēcoperācijas rezultātus. DARBA MĒRĶIS: Rast pamatojumu intramedullāras osteosintēzes vai konvencionālas metodes izvēlei distālu metakarpālo kaulu lūzumu ārstēšanā. Metodes un materiāli: Pētījumā tika iekļauti un izvērtēti 48 pacienti, kam veikt…

KIRŠNERA STIEPLESMETAKARPĀLO KAULU LŪZUMIOSTEOSINTĒZEMedicīnaPĒCOPERĀCIJAS REZULTĀTI
researchProduct

Local administration of antisense phosphorothioate oligonucleotides to the c-kit ligand, stem cell factor, suppresses airway inflammation and IL-4 pr…

2001

Abstract Background: The c-kit ligand, stem cell factor (SCF), is an important activating and chemotactic factor for both mast cells and eosinophils. These cells are known to play a fundamental role in the pathogenesis of asthma. Objective: Our goal was to analyze the functional role of SCF in the pathogenesis of asthma. Methods: The expression of SCF was targeted in fibroblasts, epithelial cells, and locally in a murine model of asthma in mice induced by ovalbumin sensitization with an antisense DNA strategy. Results: We could suppress SCF expression in NIH 3T3 fibroblasts and SP1 epithelial cells by a specific antisense phosphorothioate oligonucleotide overlapping the translation start si…

KeratinocytesLung DiseasesOvalbuminAdministration TopicalImmunologyInflammationStem cell factorBiology3T3 cellsAllergic inflammationLeukocyte CountMicemedicineImmunology and AllergyAnimalsInterleukin 4InflammationStem Cell FactorOligonucleotide3T3 CellsAllergensFibroblastsOligonucleotides AntisenseThionucleotidesMast cellAsthmaEosinophilsOvalbuminDisease Models Animalmedicine.anatomical_structureembryonic structuresImmunologybiology.proteinInterleukin-4medicine.symptomBronchoalveolar Lavage FluidThe Journal of allergy and clinical immunology
researchProduct

Ecthyma- und Keratoakanthom-�hnliche eosinophile Granulome der Haut

1967

Mitteilung einer Beobachtung rezidivierender Ecthyma-und Keratoakanthom-ahnlicher Hautveranderungen bei einem ansonsten gesunden 69 jahrigen Mann, denen histologisch — am Hohepunkt der feingeweblichen Entwicklung — reticulo-histiocytar differenzierte Granulome mit massenhaft Eosinophilen und chronisch-entzundlicher Begleitinfiltration zugrunde lagen. Nach einem Uberblick uber die Entstehung des vieldeutigen Begriffes “eosinophiles Granulom der Haut” wird — gestutzt auf die einschlagige Literatur — unter Berucksichtigung klinischer, histologischer und nosologischer Faktoren eine Einteilung der “eosinophilen Granulome der Haut” in drei Gruppen vorgeschlagen und der beobachtete Fall der zweife…

Keratoacanthomamedicine.medical_specialtybusiness.industryEosinophilic granulomaEcthymaMedicineDermatologyGeneral Medicinebusinessmedicine.diseaseDermatologyArchiv f�r Klinische und Experimentelle Dermatologie
researchProduct

Mast cells partly contribute to allergic enteritis development: Findings in two different mast cell-deficient mice

2021

Allergic enteritis (AE) is a gastrointestinal form of food allergy. The presence of mast cells and granulocytes has been detected in the inflamed tissues in AE. In this study, we aimed to elucidate the role of mast cells in AE development using two mast cell-deficient mouse strains: KIT(W-sh/W-sh) bearing the W-sash (W(sh)) inversion mutation and Cpa3Cre/+, which lack mast cells due to Cre-mediated mast cell eradication, were used in an AE experimental model. The development of clinical symptoms (e.g. drop in body temperature and weight loss) were abolished in both strains, whereas inflammatory levels of AE (e.g. villous atrophy, edema, and granulocyte accumulation) were reduced mainly in K…

LebensmittelallergieEOSINOPHILImmunologyBiologyFOOD ALLERGYMiceAllergic enteritisHypersensitivityDeficient mousemedicineAnimalsHumansImmunology and AllergyMast CellsMast (botany)ALLERGIC ENTERITISMice KnockoutMAST CELLSMOUSE MODEL//purl.org/becyt/ford/3.1 [https]Mast cellEnteritisMice Inbred C57BLmedicine.anatomical_structureImmunology//purl.org/becyt/ford/3 [https]
researchProduct