Search results for "errors"
showing 10 items of 279 documents
Cisplatin preparation error; patient management and morbidity
2009
Introduction. Antineoplastic drug therapy errors represent a high iatrogenic potential due to antineoplastic drugs narrow therapeutic ranges and the complexity of chemotherapy regimens that may increase the risk of morbidity and mortality for oncology patients.Setting. We report a 57-year-old man with head and neck cancer who mistakenly received 180 mg/ m2of cisplatin overdose despite the safety measures and validations carried out during preparation. The patient developed moderate nausea and vomiting, acute renal failure, hearing difficulty (tinnitus), and severe myelodepression.Patient management. Prophylactic and symptomatic treatments were applied in order to prevent and correct toxicit…
Comparison of higher order aberrations measured by NIDEK OPD-Scan dynamic skiascopy and Zeiss WASCA Hartmann-Shack aberrometers.
2008
<h4>PURPOSE</h4><p>To compare the measurement of wavefront aberrations in non-cyclopleged human eyes with Hartmann-Shack and dynamic skiascopy wavefront analyzers.</p> <h4>METHODS</h4><p>Eighty eyes of 40 healthy young adults (19 men, 21 women; mean age 20.8±2.5 years) with refractive errors ranging from +1.50 to –9.75 diopters (D) sphere and up to 1.75 D cylinder (mean spherical equivalent refraction –2.12±2.69 D) were examined with the Zeiss/Meditec WASCA and NIDEK OPD-Scan wavefront analyzers and with the Nippon SRW5000 binocular, open-field autorefractor without the instillation of antimuscarinic agents. Three measurements were taken with each s…
Assessment of data and parameter uncertainties in integrated water-quality model
2011
In integrated urban drainage water quality models, due to the fact that integrated approaches are basically a cascade of sub-models (simulating sewer system, wastewater treatment plant and receiving water body), uncertainty produced in one sub-model propagates to the following ones depending on the model structure, the estimation of parameters and the availability and uncertainty of measurements in the different parts of the system. Uncertainty basically propagates throughout a chain of models in which simulation output from upstream models is transferred to the downstream ones as input. The overall uncertainty can differ from the simple sum of uncertainties generated in each sub-model, dep…
A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice
2020
We previously observed an unexpected fivefold (35 vs. 200 days) difference in the survival of respiratory chain complex III (CIII) deficient Bcs1lp.S78G mice between two congenic backgrounds. Here, we identify a spontaneous homoplasmic mtDNA variant (m.G14904A, mt-Cybp.D254N), affecting the CIII subunit cytochrome b (MT-CYB), in the background with short survival. We utilize maternal inheritance of mtDNA to confirm this as the causative variant and show that it further decreases the low CIII activity in Bcs1lp.S78G tissues to below survival threshold by 35 days of age. Molecular dynamics simulations predict D254N to restrict the flexibility of MT-CYB ef loop, potentially affecting RISP dyna…
Aussprachetraining im DaF-Unterricht in der Lehr- und Lernwelt 3.0.
2018
Everyone who acquires a new language at school or elsewhere has the right to learn good pronunciation. As phonetic errors are foreseeable, this paper begins by delineating deviations in (co)articulation and prosody which are typical of Italian learners of German, with the aim of examining how far these specific, predictable phonetic problems are treated in German textbooks used in Italy. The study shows that even modern textbooks do not consider phonetics in a satisfactory way. Today’s learning world 3.0 – not only interactive, but also shaped for the individual learner – is characterized by a growing number of Computer Assisted Language Learning (CALL) and special Computer Assisted Pronunc…
Selection of the Best Subset of Variables in Regression and Time Series Models
2009
The problem of variable selection is one of the most pervasive model selection problems in statistical applications. Often referred to as the problem of subset selection, it arises when one wants to model the relationship between a variable of interest and a subset of potential explanatory variables or predictors, but there is uncertainty about which subset to use. Several papers have dealt with various aspects of the problem but it appears that the typical regression user has not benefited appreciably. One reason for the lack of resolution of the problem is the fact that it is has not been well defined. Indeed, it is apparent that there is not a single problem, but rather several problems …
Misdiagnosis and pitfalls in Panayiotopoulos syndrome
2019
Abstract Panayiotopoulos syndrome (PS) is a frequent (6% among children of 1–15 years) and benign epileptic syndrome, characterized by predominantly autonomic symptoms (emesis, pallor, flushing, cyanosis, mydriasis/miosis, cardiorespiratory and thermoregulatory alterations, incontinence of urine and/or feces, hypersalivation, and modifications of intestinal motility) associated with simple motor focal seizures, which can be followed by secondary generalization. Panayiotopoulos syndrome can be extremely insidious, because it can mimic several condition, such as gastroenteritis, gastroesophageal reflux disease, encephalitis, syncope, migraine, sleep disorders, or even metabolic diseases. This…
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: a severe fatty acid oxidation disorder
1994
3-Hydroxyacyl-CoA dehydrogenase deficiency is a newly recognised fatty acid oxidation disorder with a usually fatal outcome. We present a further patient who presented with hypoketotic hypoglycaemia, hepatopathy, secondary carnitine deficiency and increased plasma long-chain acylcarnitines. 3-Hydroxydicarboxylic aciduria was present and the diagnosis confirmed in cultured skin fibroblasts. Our patient is compared with those reported in the literature with respect to clinical symptoms, differential diagnosis and possible therapeutic regimens.
Sarcosinaemia in a retarded, amaurotic child.
1986
A 9-month-old Turkish girl demonstrated an abnormal qualitative amino acid excretion pattern suggestive of sarcosinaemia. She was blind and had evidence of developmental and motor retardation. No other physical abnormalities were noted. Quantitative amino acid analysis revealed elevated serum and urine sarcosine levels. An oral sarcosine loading test showed an exaggerated response with a delayed conversion to glycine. Sarcosine was undetected in other family members.
Personality traits and unemployment: Evidence from longitudinal data
2012
This study contributes to the literature on how personality is related to labour market success by providing evidence on the relationship between personality traits and unemployment. After accounting for reverse causality and measurement error, our results suggest that higher openness was associated with increased cumulative unemployment at the prime working age. It seems that this connection occurs because individuals with higher openness enter into unemployment spells more frequently – not because their unemployment spells would be particularly long. peerReviewed