Search results for "esbl"
showing 10 items of 34 documents
Ceftolozane-Tazobactam Combination Therapy Compared to Ceftolozane-Tazobactam Monotherapy for the Treatment of Severe Infections: A Systematic Review…
2021
Ceftolozane-tazobactam (C/T) is a combination of an advanced-generation cephalosporin (ceftolozane) with a &beta
Extraintestinal pathogenic Escherichia coli sequence type 131 H30-R and H30-Rx subclones in retail chicken meat, Italy
2016
Extraintestinal pathogenic Escherichia coli sequence type 131 (ST131), typically fluoroquinolone-resistant (FQ-R) and/or extended-spectrum β-lactamase (ESBL)-producing, has emerged globally. Among clinical isolates, ST131, primarily its H30-R and H30-Rx subclones, accounts for most antimicrobial-resistant E. coli and is the dominant E. coli strain worldwide. We assessed its prevalence and characteristics among raw chicken meat samples on sale in Palermo, Italy. A collection of 237 fluoroquinolone resistant and ESBL/AmpC producing E. coli isolates, which had been isolated from processed retail chicken meat in the period May 2013-April 2015, was analyzed. Established polymerase chain reaction…
Which non-carbapenem antibiotics are active against extended-spectrum β-lactamase-producing Enterobacteriaceae?
2018
In this study, the activity of 18 non-carbapenem antibiotics was evaluated against 100 extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (ESBL-Ec) and 50 ESBL-producing Klebsiella pneumoniae (ESBL-Kp) isolated from urinary tract infections and bacteraemia in 2016. Minimum inhibitory concentrations (MICs) were determined using reference methods and the susceptibility profiles were defined according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) 2017 recommendations. All of the ESBL-Ec isolates were susceptible to ceftazidime/avibactam and a great majority of them were susceptible to fosfomycin (98%), piperacillin/tazobactam (97%), amikacin (97%) and nitr…
Trends of extended-spectrum β-lactamase-producing Escherichia coli sequence type 131 and its H30 subclone in a French hospital over a 15-year period.
2016
International audience; Sequence type 131 (ST131) is a predominant lineage among extraintestinal pathogenic Escherichia coli. It plays a major role in the worldwide dissemination of E. coli producing extended-spectrum β-lactamases (ESBLs). Here we describe the long-term epidemiology of this clonal group in a French university hospital, where the incidence of ESBL-producing E. coli has increased from 0.018 case per 1000 patient-days in the year 2000 to 0.50 case per 1000 patient-days in 2014. The first of the 141 ST131 isolates was recovered in 2006, and the ST131 clonal group accounted for 18.1% of total ESBL-producing E. coli over the whole period (2000-2014). Subclonal typing showed that …
Characterization of ESBL-producing enterobacteria from fruit bats in an unprotected area of Makokou, Gabon.
2020
In Gabon, terrestrial mammals of protected areas have been identified as a possible source of antibiotic-resistant bacteria. Some studies on antibiotic resistance in bats have already been carried out. The main goal of our study was to detect extended-spectrum beta-lactamases (ESBLs) that are produced by enterobacteria from bats in the Makokou region in Gabon. Sixty-eight fecal samples were obtained from 68 bats caught in the forests located 1 km from the little town of Makokou. After culture and isolation, 66 Gram-negative bacterial colonies were obtained. The double-disk diffusion test confirmed the presence of ESBLs in six (20.69%) Escherichia coli isolates, four (13.79%) Klebsiella pneu…
Prevalence of Extended Spectrum Beta Lactamase Producing Bacteria in Two Surgical Wards of a General Hospital
2019
Abstract Colonisation of gastrointestinal tract by extended spectrum beta lactamase (ESBL)-producing Gram-negative bacteria is a source for infections. The present work is a prospective study in Latvia aimed to determine the role of two surgical profile wards in transmission of ESBL-producing bacteria. Differences between hospital wards were not analysed due to low number of patients. We have also determined a correlation between the duration of hospitalisation and risk of ESBL colonisation. Tests for ESBL-producing bacteria were made twice for 136 patients — upon admission and upon discharge from the hospital. Of them, 21 (15.4%) patients already were ESBL-positive at the time of admission…
Klīniski nozīmīgo gram negatīvo baktēriju rezistence pret antibakteriālajiem līdzekļiem
2015
Maģistra darba ietvaros ir apkopoti un izanalizēti materiāli no 2013. gada janvāra līdz 2013. gada decembrim. Izolāti tika iegūti no pacientu elpceļiem: bronhu atsūknējumiem, krēpām, pleiras šķidruma un biopsiju paraugiem. Šo izolātu rezistenci pret antibakteriālajiem līdzekļiem tika pārbaudīta ar beta laktāmu, hinolonu un aminoglikozīdu klases pretmikrobu līdzekļiem. Darba mērķis ir klīniski nozīmīgo Gram negatīvo baktēriju identifikācija un jutības pret antibakteriālajiem līdzekļiem noteikšana. Savukārt, lai no hemokultūras ātri identificētu baktēriju sugu, tika lietota molekulārbioloģiskā metode: GenoType BC gramnegative tests. Gram negatīvo mikroorganismu jutības noteikšanai pret antiba…
Comparison of multidrug-resistant extraintestinal pathogenic Escherichia coli from human, foods and animals to investigate the possible chains of tra…
Background Globally, antimicrobial drug resistant Escherichia coli is the most common etiological agent of invasive disease in humans. In Europe, increasing proportions of infections due to third generation cephalosporins (3GCs) and/or fluoroquinolone resistant extraintestinal pathogenic E. coli (ExPEC) strains are reported. It has been shown that multidrug resistant (MDR) E. coli can be transmitted from animals to humans and based on existing evidence, poultry is the food animal source most closely linked to human E. coli. However, lack of reliable data makes it difficult to assess the attributable risk of different food sources and their impact on human health. Objectives In the present s…
Characterization of the first extended-spectrum b-lactamase–producing nontyphoidal Salmonella strains Isolated in Tehran, Iran
2010
The infections caused by Salmonella remain a significant public health problem throughout the world. b-Lactams and fluoroquinolones are generally used to treat invasive Salmonella infections, but emergence and spread of antibiotic-resistant strains are being increasingly notified in many countries. In particular, detection of extended spectrum b-lactamases (ESBLs) in Salmonella spp. is a newly emerging threat worldwide. This study was carried out to characterize b-lactamase–producing Salmonella strains identified in Tehran, Iran. Over the 2-year period from 2007 to 2008, 6 of 136 Salmonella isolates recovered from pediatrics patients, including three Salmonella enterica serotypes Enteritidi…
EUCAST un CLSI metožu salīdzinājums paplašināta spektra βeta-laktamāžu noteikšanai Enterobacteriaceae dzimtas klīniskajos izolātos
2015
Darba mērķis bija salīdzināt EUCAST un CLSI antimikrobās jutības noteikšanas metodes paplašināta spektra β-laktamāžu noteikšanai Enterobacteriaceae dzimtas klīniskajos izolātos. Darba teorētiskajā daļā tika apskatīti biežākie ESBL producējošie Enterobacteriaceae dzimtas pārstāvji, antibakteriālo līdzekļu un rezistences mehānismu raksturojums. Dati iegūti 2014.-2015. g., strādājot klīniskajā mikrobioloģijas laboratorijā. Identificēti un pētīti 269 baktēriju izolāti. Pēc EUCAST standarta 55 izolātiem mainījās antibiogrammas rezultāti. Ceftazidīmam un cefotaksīmam samazinot antibakteriālā līdzekļa koncentrāciju pēc EUCAST standarta, tie tiek padarīti jutīgāki pret ESBL noteikšanu. Pateicoties …