Search results for "evaluation"

Evaluación de los aspectos formales de las revistas pediátricas españolas

2007

Introducción: La normalización de las revistas científicas es impresscindible para la transmisión correcta del conocimiento, pues garantiza la universalidad y reproducibilidad de las investigaciones. El objetivo de este trabajo es realizar una evaluación de los aspectos formales de las revistas pediátricas españolas. Material y métodos: En el año 2005 se estudiaron las características formales de las revistas pediátricas españolas, en particular, y de las revistas biomédicas españolas, en general. Se implementó un formulario, utilizado para la selección de las revistas que forman parte de la cobertura de la base de datos del Índice Médico Español (IME), que evaluaba 64 características difer…

Evaluation and comparison of satellite precipitation estimates with reference to a local area in the Mediterranean Sea

2014

Precipitation measurement is a key activity for the analysis of storm processes as well as every hydrological process. Satellite retrieval systems, rain-gauge network and radar systems are complement to each other in terms of their coverage and capability of monitoring precipitation. Satellite rainfall estimates systems produce data with global coverage that can provide information in areas for which data from other sources are unavailable. Without referring to ground measurement, satellite-based estimates can be bias. Although some gauged adjusted satellite precipitation products are developed, an effective way of integrating multi-sources of precipitation information is still a challenge.…

Extreme, wintertime Saharan dust intrusion in the Iberian Peninsula: Lidar monitoring and evaluation of dust forecast models during the February 2017…

2019

The research leading to these results has received funding from the H2020 program from the European Union (grant agreement no. 654109, 778349) and also from the Spanish Ministry of Industry, Economy and Competitiviness (MINECO, ref. CGL2013-45410-R, CGL2016-81092-R, CGL2017-85344-R, TEC2015-63832-P), the Spanish Ministry of Science, Innovation and Universities (ref. CGL2017-90884-REDT); the CommSensLab "Maria de Maeztu" Unity of Excellence (ref. MDM-2016-0600) financed by the Spanish Agencia Estatal de Investigación. Co-funding was also provided by the European Union through the European Regional Development Fund (ref. POCI-01-0145-FEDER-007690, ALT20-03-0145-FEDER-000004, ALT20-03-0145-FED…

Podstawowe samowartościowanie - walidacja polskiej wersji skali do pomiaru Core Self-Evaluations

2017

Praca przedstawia walidację polskiej wersji skali do pomiaru podstawowego samowartościowania (Core Self-Evaluations – CSES; Judge, Erez, Bono i Thorensen, 2003). Podstawowe samowartościowanie to poglądy danej osoby, dotyczące jej skuteczności, zdolności, wiary we własne siły i pozytywnego nastawienia do siebie i świata. Koncepcja skali jest konstruktem opartym o indywidualne zmienne dyspozycyjne, często badane w kontekście organizacyjnym. Są to: samoocena, wewnętrzne umiejscowienie kontroli, zgeneralizowana samoskuteczność oraz pozytywna afektywność. Na podstawie danych z pięciu badań przeprowadzonych w latach 2014-2016, na łącznie n=3207 osób, w większości pracujących, udało się potwierdzi…

Efficacy of the antioxidant ebselen in experimental uveitis.

1999

Inflammation results in the production of free radicals. In a model of experimental uveitis upon subcutaneous injection of endotoxin to Lewis rats, i.e., endotoxin-induced experimental uveitis (EIU), we have evaluated the status of the antioxidant capacity of ocular tissues. EIU results in a decrease of glutathione (GSH) content and glutathione peroxidase (GPx) activity in whole eye homogenates 24-h after endotoxin administration. Furthermore, an increase in malondialdehyde (MDA) content was observed in these same samples, thus confirming the involvement of oxidative stress in the pathophysiology of the process. In view of the ability of the antioxidant ebselen as GPx enzyme mimic, we teste…

Single-dose ebselen does not afford sustained neuroprotection to rats subjected to severe focal cerebral ischemia

2004

Oxygen free radicals have been involved in the pathophysiology of cerebral ischemia, especially after spontaneous or thrombolytic reperfusion. In this study with rats, we have combined a severe focal ischemic insult (2 h) and a prolonged reperfusion time (7 days) to assess the possible sustained neuroprotective effect of ebselen (10 or 100 mg/kg), a small, lipophilic organoselenium compound which mimics glutathione peroxidase. Parietal cortical perfusion was measured by laser-Doppler flowmetry, and focal cerebral ischemia was carried out by the intraluminal thread method. We have measured plasma selenium levels, brain reduced glutathione levels, as a marker of oxidative stress, and infarct …

Discovery of 5-benzyl-3-phenyl-4,5-dihydroisoxazoles and 5-benzyl-3-phenyl-1,4,2-dioxazoles as potent firefly luciferase inhibitors.

2013

Luciferase reporter assays are commonly used in high-throughput screening methods. Here, we report new firefly luciferase (FLuc) inhibitors based on 5-benzyl-3-phenyl-4,5-dihydroisoxazoles and 5-benzyl-3-phenyl-1,4,2-dioxazoles, which showed up as "false positives" in a luciferase reporter gene-based assay for nuclear receptor antagonists. The inhibition was shown to be noncompetitive for both natural enzyme substrates (d-luciferin and ATP) and selective to FLuc and proven to arise from a direct interaction between the enzyme and the inhibitor. Of the 63 evaluated compounds, 28 showed significantly better inhibition potency than the well-known inhibitor resveratrol (IC(50) = 59 nM), with fi…

Solution versus Fluorous versus Solid-Phase Synthesis of 2,5-Disubstituted 1,3-Azoles. Preliminary Antibacterial Activity Studies

2009

A small library of compounds with an oxa(thia)zole scaffold and structural diversity in both positions 2 and 5 has been synthesized. Double acylation of a protected glycine affords intermediate α-amido-β-ketoesters, which in turn can be dehydrated to afford 1,3-oxazoles or reacted with Lawesson’s reagent to furnish 1,3-thiazoles. This procedure was designed with its adaptation to fluorous techniques in mind. Thus, when a protected glycine with a fluorous tag in the ester moiety is used as a starting material, the synthesis can be easily completed without column chromatography purification of intermediate compounds with good to excellent yields, thus affording a suitable entry to the prepara…

DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF NOVEL HETEROCYCLIC DERIVATIVES AS MODULATORS OF B-DNA AND G-QUADRUPLEXES DNA FUNCTIONS

Physical exercise and prevention of falls. Effects of a Pilates training method compared with a general physical activity program

2021

Introduction Falls are the leading cause of injury-related mortality and morbidity in the elderly. Physical activity plays a key role in the prevention of falls and stimulates postural control. The aim of this study was to compare a general physical activity program for the elderly with a Pilates program to evaluate the effects on balance and on reducing the risk of falling. Materials and methods Forty-six subjects were enrolled in this study, but only 41 were included in the study. The subjects were divided into 2 groups: Pilates group (P-G) and a group following a nonspecific program of physical activity (Pa-G). Each subject underwent the hand grip test, Berg balance scale test, and postu…