Search results for "evolutionary"
showing 10 items of 4392 documents
An unusually high substitution rate in transplant-associated BK polyomavirus in vivo is further concentrated in HLA-C-bound viral peptides
2018
Infection with human BK polyomavirus, a small double-stranded DNA virus, potentially results in severe complications in immunocompromised patients. Here, we describe the in vivo variability and evolution of the BK polyomavirus by deep sequencing. Our data reveal the highest genomic evolutionary rate described in double-stranded DNA viruses, i.e., 10−3–10−5 substitutions per nucleotide site per year. High mutation rates in viruses allow their escape from immune surveillance and adaptation to new hosts. By combining mutational landscapes across viral genomes with in silico prediction of viral peptides, we demonstrate the presence of significantly more coding substitutions within predicted cog…
The contribution of epistasis to the architecture of fitness in an RNA virus
2004
4 pages, 2 figures.-- PMID: 15492220 [PubMed].-- PMCID: PMC524436.-- Additional information (Suppl. table S1: Relevant information about each single- and double-nucleotide substitution mutant created) available at: http://www.pnas.org/content/101/43/15376/suppl/DC1
Vertical transmission of naturally occurring Bunyamwera and insect-specific flavivirus infections in mosquitoes from islands and mainland shores of L…
2018
Background Many arboviruses transmitted by mosquitoes have been implicated as causative agents of both human and animal illnesses in East Africa. Although epidemics of arboviral emerging infectious diseases have risen in frequency in recent years, the extent to which mosquitoes maintain pathogens in circulation during inter-epidemic periods is still poorly understood. This study aimed to investigate whether arboviruses may be maintained by vertical transmission via immature life stages of different mosquito vector species. Methodology We collected immature mosquitoes (egg, larva, pupa) on the shores and islands of Lake Baringo and Lake Victoria in western Kenya and reared them to adults. Mo…
Evolutionary plasticity of SH3 domain binding by Nef proteins of the HIV-1/SIVcpz lentiviral lineage
2021
The accessory protein Nef of human and simian immunodeficiency viruses (HIV and SIV) is an important pathogenicity factor known to interact with cellular protein kinases and other signaling proteins. A canonical SH3 domain binding motif in Nef is required for most of these interactions. For example, HIV-1 Nef activates the tyrosine kinase Hck by tightly binding to its SH3 domain. An archetypal contact between a negatively charged SH3 residue and a highly conserved arginine in Nef (Arg77) plays a key role here. Combining structural analyses with functional assays, we here show that Nef proteins have also developed a distinct structural strategy—termed the "R-clamp”—that favors the formation …
ANALYSIS OF THE SEXUAL VARIABILITY IN THE SHELL OF THE SPANISH UPPER CRETACEOUS TURTLE DORTOKA VASCONICA (PAN-PLEURODIRA, DORTOKIDAE)
2021
The present study characterizes the morphological variability related to the sexual dimorphism in the shells of the Spanish Upper Cretaceous turtle Dortoka vasconica . This study is based on the material from its type locality: Lano, Burgos. Two morphotypes were identified there based on the posterior plastral area as well as two for the anterior plastral lobe. However, a correlation with the previously indicated morphotypes could not be established due to the disarticulation of the specimens and the limited information available on the sexual dimorphism of Pleurodira. The morphological variability previously identified for Dortoka vasconica is analysed here through a quantitative approa…
Dynamic Economic Load Dispatch using Levenberg Marquardt Algorithm
2018
Abstract Economic Load Dispatch (ELD) is a very important feature of power system network. This work proposes the novel approach which considers the constraint of ramp rate limit (RRL) to solve the ELD problem. It build up the time varying dynamic economic load dispatch in which load dispatching is calculated for each specified time interval, first it is tested with conventional lambda iteration technique and then the outcomes are used to train artificial neural network (ANN) it is based on Levenberg Marquardt algorithm (LMA).As compared with any other ANN method, the Levenberg Marquardt algorithm based dynamic economic load dispatch is more swift and precise. The propose algorithm is teste…
Looking for the best modes helps solving the MRCPSP/max
2013
The multi-mode resource-constrained project scheduling problem with minimum and maximum time lags MRCPSP/max is a very general project scheduling problem with multiple execution modes per activity, renewable and non-renewable resources and minimum and maximum time lags between activities. In this paper, we describe SA-EVA, an algorithm for the problem. SA-EVA first searches for the best mode for each activity, without considering renewable resources. In this phase a simulated annealing is applied. Once a mode vector has been chosen, the problem reduces to the RCPSP/max, which SA-EVA solves with EVA, an algorithm designed in Ballestin et al. [2009. An evolutionary algorithm for the resource-…
Holidays? Not for all. Eagles have larger home ranges on holidays as a consequence of human disturbance
2019
Human-wildlife conflicts are the object of raising concern in conservation biology. People living in urban areas are rapidly increasing worldwide and consequently the temporal pattern of occupation of natural areas for recreation is changing as well, resulting in an ever-increasing concentration of people during weekends and holidays. This is particularly evident in affluent societies, where more recreationists visit natural areas on holidays and weekends, causing disturbance to wildlife in the so-called “weekend effect”. Here, we tested the response to disturbance of 30 Bonelli's eagles tracked by high-frequency GPS/GSM telemetry. We analysed daily home-range size, a measure of changing be…
2 Genes and Their Products in Sea Urchin Development
1999
Publisher Summary This chapter focuses on the genes and their products in sea urchin development. Sea urchin embryos were among the first eukaryotes in which regulation of gene expression was studied and still represent one of the main developing systems for which most of the literature has accumulated in the past and also in recent years. The interest in the subject has, however, shifted from the molecular biology field—that is, from the study of the mechanisms of regulation of gene expression—to a field in which the role of genes and their products on development is being considered. The study of the synthesis of histones has served the purpose of trying to understand the mechanisms, unde…
On Analytical vs . Schizophrenic Procedures for Computing Music
2009
The authors present a perspective on computer music, which is based on some particular definitions of music in relation to oral culture and cybernetics. They describe some experiments with different models of neural architectures which generate original music, and then suggest that if such neural systems are rich, effective and intuitive enough to produce ‘live’ music, the understanding of their behaviour may require the development of some ‘schizophrenic’ procedures, as well as analytical ones.