Search results for "extension"
showing 10 items of 534 documents
High-Throughput Mapping of 2′-O-Me Residues in RNA Using Next-Generation Sequencing (Illumina RiboMethSeq Protocol)
2017
Detection of RNA modifications in native RNAs is a tedious and laborious task, since the global level of these residues is low and most of the suitable physico-chemical methods require purification of the RNA of interest almost to homogeneity. To overcome these limitations, methods based on RT-driven primer extension have been developed and successfully used, sometimes in combination with a specific chemical treatment. Nowadays, some of these approaches have been coupled to high-throughput sequencing technologies, allowing the access to transcriptome-wide data. RNA 2'-O-methylation is one of the ubiquitous nucleotide modifications found in many RNA types from bacteria, archaea, and eukarya.…
How to deal with Haplotype data: An Extension to the Conceptual Schema of the Human Genome
2016
[EN] The goal of this work is to describe the advantages of the application of Conceptual Modeling (CM) in complex domains, such as genomics. Nowadays, the study and comprehension of the human genome is a major challenge due to its high level of complexity. The constant evolution in the genomic domain contributes to the generation of ever larger amounts of new data, which means that if we do not manage it correctly data quality could be compromised (i.e., problems related with heterogeneity and inconsistent data). In this paper, we propose the use of a Conceptual Schema of the Human Genome (CSHG), designed to understand and improve our ontological commitment to the domain and also extend (e…
Unexpected associated microalgal diversity in the lichen Ramalina farinacea is uncovered by pyrosequencing analyses
2017
The current literature reveals that the intrathalline coexistence of multiple microalgal taxa in lichens is more common than previously thought, and additional complexity is supported by the coexistence of bacteria and basidiomycete yeasts in lichen thalli. This replaces the old paradigm that lichen symbiosis occurs between a fungus and a single photobiont. The lichen Ramalina farinacea has proven to be a suitable model to study the multiplicity of microalgae in lichen thalli due to the constant coexistence of Trebouxia sp. TR9 and T. jamesii in long-distance populations. To date, studies involving phycobiont diversity within entire thalli are based on Sanger sequencing, but this method see…
2020
Background: An adequate level of muscular fitness is related to occupational performance in military personnel, including pilots flying high performance aircraft. The aim of this study was to describe the baseline level and the change in muscular fitness between the first and the second years of the Air Force Academy among fighter pilot cadets. Methods: The muscular strength and endurance test results of 182 male fighter pilot cadets were analyzed during their first year in the Air Force Academy and one year after. Maximal isometric strength tests included trunk flexion, trunk extension and bilateral leg extension tests, whereas muscle endurance was measured with modified a sit-up test and …
Compound conditionals as random quantities and Boolean algebras
2022
Conditionals play a key role in different areas of logic and probabilistic reasoning, and they have been studied and formalised from different angles. In this paper we focus on the de Finetti's notion of conditional as a three-valued object, with betting-based semantics, and its related approach as random quantity as mainly developed by two of the authors. Compound conditionals have been studied in the literature, but not in full generality. In this paper we provide a natural procedure to explicitly attach conditional random quantities to arbitrary compound conditionals that also allows us to compute their previsions. By studying the properties of these random quantities, we show that, in f…
Attention-based Model for Evaluating the Complexity of Sentences in English Language
2020
The automation of text complexity evaluation (ATCE) is an emerging problem which has been tackled by means of different methodologies. We present an effective deep learning- based solution which leverages both Recurrent Neural and the Attention mechanism. The developed system is capable of classifying sentences written in the English language by analysing their syntactical and lexical complexity. An accurate test phase has been carried out, and the system has been compared with a baseline tool based on the Support Vector Machine. This paper represents an extension of a previous deep learning model, which allows showing the suitability of Neural Networks to evaluate sentence complexity in tw…
The periodic rural postman problem with irregular services on mixed graphs
2019
Abstract In this paper, we deal with an extension of the rural postman problem in which some links of a mixed graph must be traversed a given number of times over a time horizon. These links represent entities that must be serviced a specified number of times in some subsets of days (or periods) of the time horizon. The aim is to design a set of minimum-cost tours, one for each day/period of the time horizon, that satisfy the service requirements. We refer to this problem as the periodic rural postman problem with irregular services (PRPP–IS). Some practical applications of the problem can be found in road maintenance operations and road network surveillance, for example. In order to solve …
Molecular characterization of Treponema pallidum subsp. pallidum in Switzerland and France with a new multilocus sequence typing scheme
2018
Syphilis is an important public health problem and an increasing incidence has been noted in recent years. Characterization of strain diversity through molecular data plays a critical role in the epidemiological understanding of this re-emergence. We here propose a new high-resolution multilocus sequence typing (MLST) scheme for Treponema pallidum subsp. pallidum (TPA). We analyzed 30 complete and draft TPA genomes obtained directly from clinical samples or from rabbit propagated strains to identify suitable typing loci and tested the new scheme on 120 clinical samples collected in Switzerland and France. Our analyses yielded three loci with high discriminatory power: TP0136, TP0548, and TP…
La Sala Parpalló en el Centre Cultural La Beneficència (1995-1999)
2020
During the period 1995-1999, the Sala Parpalló was located in the Beneficència Cultural Center of Valencia, sharing the place with the spaces of the Museum of Prehistory, the Museum of Ethnology and the IVEI. In the investigation it exposed a technical file for each of the 57 self-produced exhibitions carried out in the period and a selection of the studies that accompanied them: the files are displayed chronologically according to the procedures used. The work concludes with the analysis of the objectives that were mainly all the programming: 1) Sala Parpalló as an integrated project; 2) Studies and exhibitions around the Valencian Cultural Imaginary; 3) Analysis of the postmodern crisis; …
Strong BV-extension and W1,1-extension domains
2021
We show that a bounded domain in a Euclidean space is a $W^{1,1}$-extension domain if and only if it is a strong $BV$-extension domain. In the planar case, bounded and strong $BV$-extension domains are shown to be exactly those $BV$-extension domains for which the set $\partial\Omega \setminus \bigcup_{i} \overline{\Omega}_i$ is purely $1$-unrectifiable, where $\Omega_i$ are the open connected components of $\mathbb{R}^2\setminus\overline{\Omega}$.