Search results for "fox"

Liver X Receptor Regulates Arachidonic Acid Distribution and Eicosanoid Release in Human Macrophages

2013

Objective— Liver X receptors (LXRs) are oxysterol-activated nuclear receptors that are highly expressed in macrophages and regulate lipid homeostasis and inflammation. Among putative LXR target genes, lysophosphatidylcholine acyltransferase 3 (LPCAT3) involved in the Lands cycle controls the fatty acid composition at the sn-2 position of glycerophospholipids and, therefore, the availability of fatty acids, such as arachidonic acid (AA), used for eicosanoid synthesis. The aim of our study was to determine whether LXRs could regulate the Lands cycle in human macrophages, to assess the consequences in terms of lipid composition and inflammatory response, and to work out the relative contribut…

The Difficult Marriage of Triarylcorroles with Zinc and Nickel Ions.

2022

The coordination chemistry of corrole has witnessed a great improvement in the past few years and its Periodic Table has been widened to be so large that it is compared with that of porphyrins. However, Ni and Zn ions, commonly used with porphyrins for both synthetic and theoretical purposes, are sparsely reported in the case of corroles. Here, we report synthetic protocols for preparing Ni and Zn triarylcorrole complexes. In the case of Zn, the preliminary oxidation of the free base corrole in DMSO to the neutral corrole radical is a necessary step to obtain the coordination of the metal ion, because the direct reaction led to the formation of an open-chain tetrapyrrole. The Ni complex cou…

Stereospezifische Überführung chiraler acyclischer tertiärer Phosphinsulfide in die entsprechenden tertiären Phosphinoxide mit Dimethylsulfoxid (DMSO)

1975

Die Uberfuhrung chiraler acyclischer tertiarer Phosphinsulfide in die entsprechenden tertiaren Phosphinoxide mit DMSO in saurer Losung erfolgt unter vollstandiger Inversion der Konfiguration am zentralen Phosphoratom. Aufgrund dieses stereochemischen Verlaufs wird ein Mechanismus fur die Reaktion zur Diskussion gestellt. Stereospecific Conversion of Chiral Acyclic Tertiary Phosphine Sulfides into the Corresponding Tertiary Phosphine Oxides by Means of Dimethyl Sulfoxide (DMSO) The conversion of chiral acyclic tertiary phosphine sulfides into the corresponding tertiary phosphine oxides by means of DMSO in acidic solution proceeds with complete inversion of configuration at the central phosph…

Tetrakis[(mu-hydroxo)(mu-sulfathiazolato)copper(II)] tetrakis(dimethyl sulfoxide): a new square-planar tetranuclear copper(II) complex containing fou…

2001

Confirmation of Fenthion Metabolites in Oranges by IT-MS and QqTOF-MS

2007

14 pages, 4 figures, 4 tables.-- PMID: 18020315 [PubMed].-- Printed version published Dec 15, 2007.

Human CD25+ regulatory T cells: two subsets defined by the integrins alpha 4 beta 7 or alpha 4 beta 1 confer distinct suppressive properties upon CD4…

2004

Down-regulation of autoreactive T cell responses in vivo includes cell-contact-dependent as well as contact-independent mechanisms. Infectious tolerance is a contact-dependent mechanism used by naturally occurring CD25(+) T regulatory cells (Tregs) to confer suppressive activity upon conventional CD4(+) T cells thereby generating secondary T helper suppressor cells(Th(sup)), which inhibit T cell activation via soluble mediators. Here, we describe two distinct subsets of human Tregs, characterized by expression of either the alpha(4)beta(7) integrin or the alpha(4)beta(1) integrin. Upon activation, both subsets show an enhanced expression of FoxP3, recently described as a key transcription f…

A Coexistence Study of Low-Power Wide-Area Networks based on LoRaWAN and Sigfox

2023

According to IoT Analytics, NB-IoT, LoRaWAN, and Sigfox are today the most popular technologies for low-power wide-area networks (86% of the market), both in terms of end-user adoption as well as ecosystem support. While NB-IoT utilizes licensed bands, LoRaWAN and Sigfox both employ the sub-GHz ISM bands, potentially interfering with each other.In this paper, we present a thorough coexistence study between LoRaWAN and Sigfox, in realistic urban scenarios, with different duty cycles and traffic conditions. The choice of such scenarios and simulation parameters are supported by an in-depth lit-erature review, and simulations are based on the SEAMCAT simulator. The results offer new insights o…

Expansion of intestinal CD4+CD25highTreg cells in patients with ankylosing spondylitis: A putative role for interleukin-10 in preventing intestinal T…

2010

Objective Subclinical gut inflammation has been demonstrated in patients with ankylosing spondylitis (AS). This study was undertaken to determine the frequency of regulatory CD4+CD25high T cells (Treg cells) and to evaluate Treg cell–related cytokines (interleukin-2 [IL-2], transforming growth factor β [TGFβ], and IL-10) and transcription factors (FoxP3 and STAT-5) in the ileum of patients with AS. Methods Quantitative gene expression analysis, by reverse transcriptase–polymerase chain reaction, of Treg-related cytokines (IL-2, TGFβ, and IL-10) and transcription factors (STAT-5 and FoxP3) was performed on ileal biopsy specimens from 18 patients with AS, 15 patients with active Crohn's disea…

Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27

2011

Accumulating evidence indicates that IL-27, a member of the IL-12 family of cytokines, alleviates the severity of autoimmune diseases in both mice and men. The IL-27-induced activation of signal transducer and activator of transcription (Stat)1 and Stat3 promotes the generation of IL-10- producing type 1 regulatory T (Tr1) cells that inhibit effector T cells. In addition, IL-27 also suppresses the development of pathogenic IL-17-producing CD4(+) T cells (T(H)17) cells suggesting that pharmacological manipulations of IL-27 signaling pathway could be exploited therapeutically in regulating tissue inflammation. Here, we review how IL-27 controls inflammation through the regulation of Tr1 and T…

Langerhans cells are negative regulators of the anti-Leishmania response

2011

Langerhans cells suppress the immune response to low-dose Leishmania major infection in part by inducing regulatory T cells.