Search results for "fusion"
showing 10 items of 4513 documents
Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Hormones of Energy Balance in a TCDD-Sensitive and a TCDD-Resistant Rat Strain
2014
One of the hallmarks of the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a drastically reduced feed intake by an unknown mechanism. To further elucidate this wasting syndrome, we followed the effects of a single large dose (100 μg/kg) of TCDD on the serum levels of several energy balance-influencing hormones, clinical chemistry variables, and hepatic aryl hydrocarbon receptor (AHR) expression in two rat strains that differ widely in their TCDD sensitivities, for up to 10 days. TCDD affected most of the analytes in sensitive Long-Evans rats, while there were few alterations in the resistant Han/Wistar strain. However, analyses of feed-restricted unexposed Long-Evans rats i…
Staphylococcal alpha-toxin provokes neutrophil-dependent cardiac dysfunction: role of ICAM-1 and cys-leukotrienes.
2002
The role of polymorphonuclear neutrophils (PMN) in septic myocardial dysfunction is presently unknown. Staphylococcus aureus infections are frequently associated with septic sequelae. Therefore, we perfused isolated rat hearts with low doses of α-toxin, the major staphylococcal exotoxin, followed by application of human PMN, N-formyl-methionyl-leucyl-phenylalanine, and arachidonic acid. In contrast to sham-perfused hearts (no α-toxin), a rise in coronary perfusion pressure (CPP) and a reduction of contractile function were noted, and cardiac expression of intercellular adhesion molecule (ICAM)-1 was detected by immunohistochemical methods and real-time PCR. Histological analysis and myelope…
Efficacy of intra-arterial lidocaine infusion in the treatment of cerulein-induced acute pancreatitis
2020
Background Disturbances in pancreatic microcirculation, beginning with vasoconstriction, are crucial in early pancreatitis and progression to necrotizing pancreatitis. Thus, vascular-targeted treatment aiming to restore a sufficient level of microcirculation through vasodilation would possibly reduce the severity of pancreatitis. Lidocaine is an anti-arrhythmic and local anesthetic drug, which also acts as a vasodilator at higher concentrations. Objectives To evaluate the efficacy of intra-arterial infusion of lidocaine into the celiac trunk in treatment of cerulein-induced acute pancreatitis. Material and methods Wistar rats (n = 20) were randomly divided into 2 equal groups: the control g…
eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1.
2017
The actin cytoskeleton coordinates the organization of signaling microclusters at the immune synapse (IS); however, the mechanisms involved remain poorly understood. We show here that nitric oxide (NO) generated by endothelial nitric oxide synthase (eNOS) controls the coalescence of protein kinase C-¿ (PKC-¿) at the central supramolecular activation cluster (c-SMAC) of the IS. eNOS translocated with the Golgi to the IS and partially colocalized with F-actin around the c-SMAC. This resulted in reduced actin polymerization and centripetal retrograde flow of ß-actin and PKC-¿ from the lamellipodium-like distal (d)-SMAC, promoting PKC-¿ activation. Furthermore, eNOS-derived NO S-nitrosylated ß-…
Halogenido ligand exchange synthesis, spectroscopic properties and thermal behaviour of the inorganic–organic hydrogen-bonded network solid [4,4′-H2b…
2014
Abstract Dark-red single crystals of 4,4′-bipyridinium triaquahydrogen(1+) hexabromidorhodate(III) [4,4′-H2bipy][H7O3][RhBr6] (1) have been synthesized by a diffusion-controlled ligand exchange process from rhodium(III) chloride trihydrate and 4,4′-bipyridine dissolved in hydrochloric and hydrobromic acid, respectively. 1 could be considered as an inorganic–organic hydrogen-bonded network solid built up from the inorganic isolated hexabromidorhodate [RhBr6]3− octahedra, organic 4,4′-bipyridinium(2+) [4,4′-H2bipy]2+ and triaquahydrogen(1+) [H7O3]+ cations with nearly symmetrical O⋯O distances. The oppositely charged components in the structure of 1 are bound together by an intricate system o…
Insertion of light-harvesting chlorophyll a/b protein into the thylakoid
2000
The major light-harvesting chlorophyll a/b-binding protein (Lhcb1,2) of photosystem II is inserted into the thylakoid via the signal recognition particle dependent pathway. However, the mechanism by which the protein enters the membrane is at this time unknown. In order to define some topographical restrictions for this process, we constructed several recombinant derivatives of Lhcb1 carrying hexahistidine tags at either protein terminus or in the stromal loop domain. Additionally, green fluorescent protein (GFP) was fused to either terminus. None of the modifications significantly impair the pigment-binding properties of the protein in the in vitro reconstitution of LHCII. With the excepti…
De l'association à la fusion de communes, leçon de ponctuation
2013
International audience
Some diffusion equations with finite propagation speed
2007
We summarize some of our recent results on diffusion equations with finite speed of propagation. These equations have been introduced to correct the infinite speed of propagation predicted by the classical linear diffusion theory. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Aspects discursifs dans les contes d’ Edgar Allan Poe et leurs traductions en français et en espagnol
2012
It is known that the translation exercise has always been important in the development of the human knowledge. That is why we have considered interesting to analyse the French and Spanish translations of Edgar Allan Poe’s Tales. The aim of this contribution is the study of temporal cohesion in a cognitive approach. We have chosen three Tales of Edar Allan Poe: Berenice, The Oval Portrait, and The Masque of the Red Death. In a first step we’ll find the three markers still, again and then among the three Tales and in a second step we will compare the translations (French and Spanish ) of these markers with the original text. We think that these markers are polysemous and that they have a prot…