Search results for "fusion"

Role of hepatocyte nuclear factor 3γ in the expression of human CYP2C genes

2004

Hepatocyte nuclear factor 3 gamma (HNF-3 gamma) is an important transcription factor for the maintenance of specific liver functions. However, its relevance in the expression of human cytochrome P450 (CYP) genes has not yet been explored. Several HNF3 putative binding sites can be identified in human CYP2C 5'-flanking regions. Gene reporter experiments with proximal promoters revealed that HNF-3 gamma transactivated CYP2C8, CYP2C9, and CYP2C19 (25-, 4-, and 4-fold, respectively), but it did not transactivate CYP2C18. However, overexpression of HNF-3 gamma in hepatoma cells by means of a recombinant adenovirus induced CYP2C9, CYP2C18, and CYP2C19 mRNA (4.5-, 20-, and 50-fold, respectively) b…

Impairing Otp homeodomain function in oral ectoderm cells affects skeletogenesis in sea urchin embryos

2003

AbstractIn the sea urchin embryo skeletogenesis is the result of a complex series of molecular and cellular events that coordinate the morphogenetic process. Past and recent evidence strongly indicate that skeletal initiation and growth are strictly dependent on signals emanating from the oral ectodermal wall. As previously suggested, Orthopedia (Otp), a homeodomain-containing transcription factor specifically expressed in a small subset of oral ectoderm cells, might be implicated in this signalling pathway. In this study, we utilize three different strategies to address the issue of whether Otp is an upstream regulator of sketelogenesis. We describe the effects of microinjection of Otp mor…

Stratification dépendante du temps dans la modélisation de Cox en tant que méthode de prise en compte d’interventions répétées dans la prise en charg…

2016

International audience; IntroductionLa transfusion de concentrés de globules rouges (CGR) est le traitement symptomatique de l’anémie et contribue à l’oxygénation des tissus au cours de pathologies sévères. Nous menons une recherche sur l’effet des caractéristiques des CGRs sur la survie des patients dans les CHU de Besançon et Dijon : l’étude STeF-BFC. Nous étudions l’effet de la durée de conservation (DC) et du sexe du donneur (SD) des CGR sur la survie à un an de patients de chirurgie cardiovasculaire. Dans ce type d’étude, le nombre de CGR reçus est un facteur de confusion majeur. Il s’agit d’un biais d’indication mais aussi un biais de survivant (il faut avoir survécu jusqu’à la transf…

Effet bénéfique de la transfusion à la phase aiguë de l’infarctus du myocarde du sujet âgé : étude prospective de 3316 cas

2016

IF 0.905; International audience; IntroductionL’anémie est fréquente dans la population âgée à la phase aiguë d’un infarctus du myocarde (IDM) et est associée à une augmentation de la mortalité à long terme. Cependant, le bénéfice de la transfusion de concentrés de globules rouges (TCGR) dans ce contexte reste incertain.Patients et méthodesTous les patients de 65 ans et plus, hospitalisés pour un IDM dans notre centre hospitalier universitaire ont été inclus prospectivement. Ils ont été séparés en deux groupes d’âges : les plus jeunes (65–79 ans) et les plus âgés (80 ans et plus) et trois sous-groupes de nadir de taux d’hémoglobine (NH) (≤ 8,8–10 et > 10 g/dL). Nous avons étudié l’associati…

Diffusion of oxygen in cork.

2012

International audience; This work reports measurements of effective oxygen diffusion coefficient in raw cork. Kinetics of oxygen transfer through cork is studied at 298 K thanks to a homemade manometric device composed of two gas compartments separated by a cork wafer sample. The first compartment contains oxygen, whereas the second one is kept under dynamic vacuum. The pressure decrease in the first compartment is recorded as a function of time. The effective diffusion coefficient D-eff is obtained by applying Fick's law to transient state using a numerical method based on finite differences. An analytical model derived from Fick's law applied to steady state is also proposed. Results give…

Translational diffusion coefficients of volatile compounds in various aqueous solutions at low and subzero temperatures.

2005

International audience; Translational diffusion coefficients (D(12)) of volatile compounds were measured in model media with the profile concentration method. The influence of sample temperature (from 25 to -10 degrees C) was studied on translational diffusion in sucrose or maltodextrin solutions at various concentrations. Results show that diffusivity of volatile compounds in sucrose solutions is controlled by temperature, molecule size, and the viscosity of the liquid phase as expected with the Stokes-Einstein equation; moreover, physicochemical interactions between volatile compounds and the medium are determinant for diffusion estimation. At negative temperature, the winding path induce…

P1082COMPARISON OF THE REMOVAL OF PROTEIN-BOUND TOXINS AND LARGE MIDDLE MOLECULES WITH HIGH-FLUX PMMA AND MEDIUM CUT-OFF DIALYZERS

2020

Abstract Background and Aims Dialytic clearance of protein-bound toxins and large middle molecules is poor by diffusive treatment and limited by high-flux hemodialysis (HD) and on-line hemodiafiltration (OL-HDF), and only a few studies have examined how to improve their removal by other extracorporeal strategies. Since 2017, there is a new generation of polymethyl methacrylate (PMMA) membranes that suppress platelet adhesion on the membrane surface improving hemocompatibility and permeability, while also maintaining adsorption properties related to conventional PMMA membranes. Expanded HD (HDx) with medium cut-off (MCO) membranes has also recently been incorporated into clinical practice an…

RATIONALE FOR THE USE OF ANTIOXIDANT VITAMINS IN CLINICAL ORGAN TRANSPLANTATION

1996

Liver Preservation by Aortic Perfusion Alone Compared With Preservation by Aortic Perfusion and Additional Arterial Ex Situ Back-Table Perfusion With…

2017

Background. Arterial ex situ back-table perfusion (BP) reportedly reduces ischemic-type biliary lesion after liver transplantation. We aimed to verify these findings in a prospective investigation. Methods. Our prospective, randomized, controlled, multicenter study involved livers retrieved from patients in 2 German regions, and compared the outcomes of standard aortic perfusion to those of aortic perfusion combined with arterial ex situ BP. The primary endpoint was the incidence of ischemic-type biliary lesions over a follow-up of 2 years after liver transplantation, whereas secondary endpoints included 2-year graft survival, initial graft damage as reflected by transaminase levels, and fu…

The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging stu…

2017

Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N = 2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared …