Search results for "g(1)"
showing 10 items of 717 documents
Percepción del riesgo de inundación en el municipio de Ontinyent (Comunitat Valenciana)
2019
En la Comunidad Valenciana, los episodios de inundaciones generan un fuerte impacto en la sociedad y su territorio. La torrencialidad de las precipitaciones del clima mediterráneo, junto a las características de las cuencas de drenaje de la vertiente levantina y la fuerte ocupación urbanística en zonas inundables, son factores que agravan el riesgo de inundación. Sin embargo, en numerosas ocasiones los habitantes de un municipio no son conscientes del riesgo al que están sometidos. Por ello, junto al estudio de la peligrosidad natural, el análisis de la percepción del riesgo por parte de la población expuesta constituye un importante indicador de vulnerabilidad, ya que está condicionando el…
El macro-modelat de la costa carbonàtica de Victòria (Austràlia): paral.lelismes i diferències amb les cales baleàriques
2019
Les cales són penetracions marines, preferentment a un litoral carbonatat de caràcter tabular, arran de la inundació eustàtica d’un antic curs fluvial en la morfogènesi de les quals, de més a més del paper de la fracturació distensiva i la carstificació, també hi participen els mecanismes de col·lapse i la dinàmica litoral així com les variacions glacio-eustàtiques del nivell marí, especialment durant el Quaternari. El present treball aborda la tipologia i característiques dels elements del macro-modelat de la costa rocosa de Victòria (sud d’Austràlia) i les compara amb els antecedents i el coneixement obtingut en l’estudi de les cales de la Mediterrància occidental, principalment les de le…
Quinientos planos de alineación de la ciudad de Valencia (1860-1909)
2018
Los llamados planos de alineación recogen las modificaciones realizadas en el callejero histórico de una ciudad con la finalidad de regularizarlo. En España comenzaron a levantarse, en ciudades como Barcelona y Valencia, a mediados del siglo XVIII y se generalizaron en la segunda mitad del siglo XIX. Sus autores fueron los arquitectos municipales y los técnicos que trabajaron bajo sus órdenes en los negociados de policía urbana y las secciones de obras públicas de los mayores ayuntamientos. Herramientas de gran utilidad en la gestión urbana, estos planos iban unidos a expedientes administrativos en los que se resolvían las solicitudes particulares de licencias de obra y se obligaba a los de…
The impact of the farming, abandonment and agricultural intensification on loss of water and soil. The example of the northern slopes of the Serra Gr…
2012
Land abandonment throughout the twentieth century led to an intense landscape transformation in the mountain areas of the Iberian Peninsula. In some cases, and after 50 years of abandonment, agriculture returned with the development of commercial farms and the intensification of the agrarian activities. In the Easter Iberian Peninsula, following the abandonment of olive groves, vineyards and cereals during the 50's, has been in the past two decades the expansion of intensive citrus production on sloping terrain. Geomorphological transects and simulated rainfall experiments have quantified the impact of traditional rainfed cultivation of the 50's, abandonment, and the intensification of farm…
Claridad y calidad de las notas explicativas en estados financieros bajo IFRS. Un estudio de brechas de Expectativas Gaps para normas contables (NIC …
2018
Este análisis situacional de la claridad y calidad de las notas explicativas en los estados financieros bajo IFRS (Obligatory Disclosure), pretende entregar claridad acerca de la calidad de la información entregada en las notas explicativas para 4 normas de Información Contable, claves en la información financiera en los países de la región, que son la NIC 2; Notas referente a Inventarios, NIC 16; Notas referente a Propiedad Planta y Equipos, NIC 37; Notas referente a Provisiones, y NIC 38; Notas referente a Activos Intangibles. Adicionalmente, este trabajo estudia la brecha de expectativas (Expectation Gaps) que existe en la información entregada en las notas de los estados financieros par…
The transcription factor NFATc2 controls IL-6–dependent T cell activation in experimental colitis
2008
The nuclear factor of activated T cells (NFAT) family of transcription factors controls calcium signaling in T lymphocytes. In this study, we have identified a crucial regulatory role of the transcription factor NFATc2 in T cell–dependent experimental colitis. Similar to ulcerative colitis in humans, the expression of NFATc2 was up-regulated in oxazolone-induced chronic intestinal inflammation. Furthermore, NFATc2 deficiency suppressed colitis induced by oxazolone administration. This finding was associated with enhanced T cell apoptosis in the lamina propria and strikingly reduced production of IL-6, -13, and -17 by mucosal T lymphocytes. Further studies using knockout mice showed that IL-…
A Critical Regulatory Role of Leucin Zipper Transcription Factor c-Maf in Th1-Mediated Experimental Colitis
2004
Abstract In this study, we investigated the role of c-Maf, a transcription factor known to induce IL-4 production, in inflammatory bowel diseases and experimental colitis. Although Crohn′s disease (CD) is associated with low IL-4 production by T-bet-expressing Th1 cells in the lamina propria, surprisingly a higher expression of c-Maf in these cells was found as compared with control patients. The relevance of this finding was further evaluated in an animal model of CD induced by adoptive transfer of CD4+CD62L+ T cells in RAG-deficient mice. In this Th1-mediated model, an increase of c-Maf-expressing T lymphocytes in the lamina propria over time was observed. Interestingly, adoptive transfer…
Interferon-Beta Therapy of Multiple Sclerosis Patients Improves the Responsiveness of T Cells for Immune Suppression by Regulatory T Cells
2015
Multiple sclerosis (MS) is an inflammatory autoimmune disease characterized by imbalanced immune regulatory networks, and MS patient-derived T effector cells are inefficiently suppressed through regulatory T cells (Treg), a phenomenon known as Treg resistance. In the current study we investigated T cell function in MS patients before and after interferon-beta therapy. We compared cytokine profile, responsiveness for Treg-mediated suppression ex vivo and evaluated reactivity of T cells in vivo using a humanized mouse model. We found that CD4+ and CD8+ T cells of therapy-naive MS patients were resistant to Treg-mediated suppression. Treg resistance is associated with an augmented IL-6 product…
Reproductive health problems in rural South African young women: risk behaviour and risk factors
2018
Background South African young women continue to be vulnerable, with high prevalence of teenage pregnancy, HIV, sexually transmitted infections (STIs) and female genital schistosomiasis (FGS). This study seeks to examine the underlying factors that may be associated with these four adverse reproductive health outcomes. Methods In a cross-sectional study of 1413 sexually active of young women, we explored these four adverse reproductive health outcomes by considering socio-demographic factors, socio-economic factors, sexual risk behaviour, substance abuse and knowledge about reproductive health by using a questionnaire. Consenting participants were asked about previous pregnancies and were t…
Knockdown of NANOG Reduces Cell Proliferation and Induces G0/G1 Cell Cycle Arrest in Human Adipose Stem Cells
2019
The core components of regenerative medicine are stem cells with high self-renewal and tissue regeneration potentials. Adult stem cells can be obtained from many organs and tissues. NANOG, SOX2 and OCT4 represent the core regulatory network that suppresses differentiation-associated genes, maintaining the pluripotency of mesenchymal stem cells. The roles of NANOG in maintaining self-renewal and undifferentiated status of adult stem cells are still not perfectly established. In this study we define the effects of downregulation of NANOG in maintaining self-renewal and undifferentiated state in mesenchymal stem cells (MSCs) derived from subcutaneous adipose tissue (hASCs). hASCs were expanded…