Search results for "gellan"
showing 10 items of 50 documents
Preparation and Characterization of Gold Nanorods Coated with Gellan Gum and Lipoic Acid
2020
Gold nanorods (AuNRs) can combine therapeutic hyperthermia with diagnostic features, representing a smart choice to address personalized cancer treatments. In this regard, a crucial quest is the selection of the right biocompatible coating agent able to stabilize them in the physiological environment, further endowing the possibility to load bioactive molecules and/or targeting moieties. Therefore, AuNRs optical properties can be successfully merged with advantageous materials features to obtain selective photothermal therapy (PTT) systems. Here, the natural materials lipoic acid (LA) and the polysaccharide gellan gum (GG) were chosen to prepare three types of stabilized gold nanorods, usin…
Dust Production and Particle Acceleration in Supernova 1987A Revealed with ALMA
2013
Supernova (SN) explosions are crucial engines driving the evolution of galaxies by shock heating gas, increasing the metallicity, creating dust, and accelerating energetic particles. In 2012 we used the Atacama Large Millimeter/Submillimeter Array to observe SN 1987A, one of the best-observed supernovae since the invention of the telescope. We present spatially resolved images at 450um, 870um, 1.4mm, and 2.8mm, an important transition wavelength range. Longer wavelength emission is dominated by synchrotron radiation from shock-accelerated particles, shorter wavelengths by emission from the largest mass of dust measured in a supernova remnant (>0.2Msun). For the first time we show unambig…
On the nature of a shell of young stars in the outskirts of the Small Magellanic Cloud
2019
Understanding the evolutionary history of the Magellanic Clouds requires an in-depth exploration and characterization of the stellar content in their outer regions, which ultimately are key to tracing the epochs and nature of past interactions. We present new deep images of a shell-like over-density of stars in the outskirts of the Small Magellanic Cloud (SMC). The shell, also detected in photographic plates dating back to the fifties, is located at ~1.9 degr from the center of the SMC in the north-east direction.The structure and stellar content of this feature were studied with multi-band, optical data from the Survey of the MAgellanic Stellar History (SMASH) carried out with the Dark Ene…
In vivo efficacy of verteporfin loaded gold nanorods for combined photothermal/photodynamic colon cancer therapy.
2022
The high incidence of cancer recurrences and the frequent occurrence of multidrug resistance often stem from a poorly selective and inefficient antineoplastic therapy, responsible for the onset of undesired side effects as well. A combination of minimal-invasive approaches could thus be a useful strategy to surmount these shortcomings, achieving a safe and solid cancer therapy. Herein, a multi-therapeutic nanotool was designed by merging the photothermal properties of gold nanorods (AuNRs) with the photodynamic activity of the photosensitizer ver-teporfin. AuNRs were coated with the natural materials lipoic acid and gellan gum (AuNRs_LA,GG) and subse-quently loaded with verteporfin (AuNRs_L…
Gellan gum-based delivery systems of therapeutic agents and cells.
2020
The purpose of this review is to make a summary of high quality research trends using gellan gum (GG) as a polymeric constituent for the design of innovative drug delivery systems and devices for biomedical applications, such as cell therapy and regenerative medicine. The use of gellan gum is described both in its native form and as chemically functionalized derivatives or physically mixed with natural or synthetic materials. Starting from a systematic study of recent research works, the main properties of the native polysaccharide have been highlighted and therefore some improvements have been focused thanks to the design of chemically functionalized derivatives and the use of composite ma…
ALMA observations of Molecules in Supernova 1987A
2017
AbstractSupernova (SN) 1987A has provided a unique opportunity to study how SN ejecta evolve in 30 years time scale. We report our ALMA spectral observations of SN 1987A, taken in 2014, 2015 and 2016, with detections of CO, 28SiO, HCO+ and SO, with weaker lines of 29SiO.We find a dip in the SiO line profiles, suggesting that the ejecta morphology is likely elongated. The difference of the CO and SiO line profiles is consistent with hydrodynamic simulations, which show that Rayleigh-Taylor instabilities causes mixing of gas, with heavier elements much more disturbed, making more elongated structure.Using 28SiO and its isotopologues, Si isotope ratios were estimated for the first time in SN 1…
Album: A Tool for the Analysis of Slitless Spectra and its Application to ESO WFI Data
2008
ALBUM is a general-purpose tool to visualize and screen large amounts of slitless spectra∈dex slitless spectra. It was developed for a search for emission-line stars in SMC and LMC clusters. The observations were obtained with ESO’s Wide Field Imager (WFI∈dexWFI) and comprise ~8 million low-resolution spectra. The tool as well as the results of its application to the SMC part of the database are presented. The inferred frequency of Be stars is compared to the one in the higher-metallicity environment of the Milky Way.
Spectral Analysis of LMC X-2 with XMM-Newton: Unveiling the Emission Process in the Extragalactic Z-source
2008
We present the results of the analysis of an archival observation of LMC X-2 performed with XMM/Newton. The spectra taken by high-precision instruments have never been analyzed before. We find an X-ray position for the source that is inconsistent with the one obtained by ROSAT, but in agreement with the Einstein position and that of the optical counterpart. The correlated spectral and timing behaviour of the source suggests that the source is probably in the normal branch of its X-ray color-color diagram. The spectrum of the source can be fitted with a blackbody with a temperature 1.5 keV plus a disk blackbody at 0.8 keV. Photoelectric absorption from neutral matter has an equivalent hydrog…
Kicked neutron stars and microlensing
1996
Due to the large kick velocities with which neutron stars are born in supernovae explosions, their spatial distribution is more extended than that of their progenitor stars. The large scale height of the neutron stars above the disk plane makes them potential candidates for microlensing of stars in the Large Magellanic Cloud. Adopting for the distribution of kicks the measured velocities of young pulsars, we obtain a microlensing optical depth of $\tau \sim 2 N_{10} \times 10^{-8}$ (where $N_{10}$ is the total number of neutron stars born in the disk in units of $10^{10}$). The event duration distribution has the interesting property of being peaked at $T \sim 60$--80 d, but for the rates t…
Bepposax: 3 Years of Operation
2001
BeppoSAX, the X-Ray Astronomy satellite operating in the (0.1–300) keY energy band has now lived more than 30.000 hours in orbit and it is halfway to complete the 3rd round of observations (A03 started at the beginning of may 1999 and it will end in April 2000). A report is given on the general fields covered by the mission and on the more relevant results obtained. The satellite is in excellent operating conditions and it is foreseen to continue the observational life-time well beyond the initially scheduled 3 years.