Search results for "geriatric"
showing 10 items of 1602 documents
Effect of COVID-19 quarantine on cognitive, functional and neuropsychiatric symptoms in patients with mild cognitive impairment and dementia.
2022
Abstract Background During the last two years, COVID-19 affected older people with dementia or mild cognitive impairment (MCI), but conflicting and sparse results are still present. The objective of this study was to investigate the frequency and type of changes in functional, cognitive and behavioral and psychological symptoms of dementia (BPSD), and caregiver’s stress during the period of quarantine in 2020 in patients affected by dementia/MCI living in Palermo, Sicily. Methods Outpatients affected by MCI/dementia were evaluated before and after COVID-19 quarantine. Functional status was investigated using basic and instrumental activities of daily living (ADL); cognitive performance with…
A twin study on the heritability of walking ability among older women
2006
BACKGROUND This study examined the role of genetic and environmental factors explaining individual differences in women's walking ability in old age. METHODS A maximal walking speed test over 10 meters and a 6-minute walking endurance test were done under standard conditions among 92 monozygotic and 105 dizygotic pairs of twin sisters reared together, aged 63-75 years. RESULTS The mean maximum walking speed was 1.73 +/- 0.32 m/s and the mean distance covered in the 6-minute walking test was 525.6 +/- 77.3 m. Multivariate genetic modeling showed that a minor part of the variances in walking speed (16%, 95% confidence interval [CI]: 0%-54%) and endurance (20%, 95% CI: 0%-56%) were accounted f…
Secretory process: the role of age, autoimmunity and endocrinopathy
2020
Xerostomia is a common occurrence in older people, impairing their quality of life. When salivary gland function goes below 50%, patients show oral mucosal dryness and consequent problems on speaking and eating. They present oral health impairment. Their quality of life is compromised too. The prevalence of xerostomia is reported to be approximately 30% in people over 65 years old. Drug-induced xerostomia is the most common cause of dry mouth in elderly, because many older adults are taking at least one medication that causes salivary dysfunction. Among the autoimmune disease that can cause xerostomia, Sjogren’s syndrome (SS) is the most representative one in elderly. Dryness of oral mucosa…
Beneficios del ejercicio físico en población mayor institucionalizada
2010
Resumen Objetivo Evaluar la eficacia del ejercicio fisico sobre el nivel fisico, funcional y psicologico de personas mayores institucionalizadas. Material y metodo Estudio cuasi-experimental sobre personas mayores institucionalizadas en dos residencias. La intervencion consistio en un programa de ejercicio fisico suave de 2 sesiones semanales de 60 min durante 8 semanas. Se evaluo la movilidad articular, fuerza muscular, marcha y equilibrio, situacion funcional, dolor, estado cognitiva y sensacion de bienestar psicologico. Resultados Los participantes se dividieron en grupo de intervencion (n=24) y grupo control (n=27). Se obtuvieron mejorias estadisticamente significativas en la extension …
Efecto del ejercicio físico sobre las alteraciones cognitivas y el estrés oxidativo en un modelo transgénico APP/PSN1 para la enfermedad de Alzheimer
2012
Resumen Introduccion Los efectos beneficiosos del ejercicio fisico, tanto en el tratamiento como en la prevencion de distintas enfermedades, han sido ampliamente establecidos. La demencia mas frecuente, la enfermedad de Alzheimer (EA) es un trastorno donde el ejercicio ha demostrado causar notables mejoras fisiopatologicas y cognitivas. En el presente trabajo estudiamos el efecto del ejercicio fisico sobre el estres oxidativo y la cognicion en el modelo murino doble transgenico (2×Tg) para la EA, APP/PSN1, basado fundamentalmente en la deposicion cerebral de placas de β-amiloide. Material y metodos Dieciocho ratones de 10 meses de edad fueron divididos en 4 grupos experimentales: 2×Tg entre…
Building Bridges for Innovation in Ageing: Synergies between Action Groups of the EIP on AHA.
2017
The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The …
Glutathione, oxidative stress and aging
1996
The free radical theory of aging proposes that the impairment in physiological performance associated with aging is caused by the detrimental effects of oxygen free radicals. This is interesting because it provides us with a theoretical framework to understand aging and because it suggests a rationale for intervention, i.e., antioxidant administration. Thus, the study of antioxidant systems of the cell may be very important in gerontological studies. Glutathione is one of the main nonprotein antioxidants in the cell which, together with its related enzymes, constitute the “glutathione system.” The involvement of glutathione in aging has been known since the early seventies. Several studies …
Progerin expression induces a significant downregulation of transcription from human repetitive sequences in iPSC-derived dopaminergic neurons.
2019
Repetitive DNA sequences represent about half of the human genome. They have a central role in human biology, especially neurobiology, but are notoriously difficult to study. The purpose of this study was to quantify the transcription from repetitive sequences in a progerin-expressing cellular model of neuronal aging. Progerin is a nuclear protein causative of the Hutchinson–Gilford progeria syndrome that is also incrementally expressed during the normal aging process. A dedicated pipeline of analysis allowed to quantify transcripts containing repetitive sequences from RNAseq datasets oblivious of their genomic localization, tolerating a sufficient degree of mutational noise, all with low c…
Update on the ESCEO recommendation for the conduct of clinical trials for drugs aiming at the treatment of sarcopenia in older adults
2020
Abstract Background In 2016, an expert working group was convened under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and formulated consensus recommendations for the conduct of clinical trials for drugs to prevent or treat sarcopenia. Aims The objective of the current paper is to provide a 2020 update of the previous recommendations in accordance with the evidence that has become available since our original recommendations. Methods This paper is based on literature reviews performed by members of the ESCEO working group and followed up with face to face meetings organized for the whole group to make amendments and discuss…
European undergraduate curriculum in geriatric medicine developed using an international modified Delphi technique.
2014
Introduction: the rise in the number of older, frail adults necessitates that future doctors are adequately trained in the skills of geriatric medicine. Few countries have dedicated curricula in geriatric medicine at the undergraduate level. The aim of this project was to develop a consensus among geriatricians on a curriculum with the minimal requirements that a medical student should achieve by the end of medical school. Methods: a modified Delphi process was used. First, educational experts and geriatricians proposed a set of learning objectives based on a literature review. Second, three Delphi rounds involving a panel with 49 experts representing 29 countries affiliated to the European…