Search results for "glia"
showing 10 items of 1274 documents
2016
Cytoglobin (Cygb) is a vertebrate globin with so far poorly defined function. It is expressed in the fibroblast cell-lineage but has also been found in neurons. Here we provide, using immunohistochemistry, a detailed study on the distribution of Cygb in the mouse brain. While Cygb is a cytoplasmic protein in active cells of the supportive tissue, in neurons it is located in the cytoplasm and the nucleus. We found the expression of Cygb in all brain regions, although only a fraction of the neurons was Cygb-positive. Signals were of different intensity ranging from faint to very intense. Telencephalic neurons in all laminae of the cerebral cortex, in the olfactory bulb (in particular periglom…
The Cumulative Effect of Transient Synchrony States on Motor Performance in Parkinson's Disease.
2020
Bursts of beta frequency band activity in the basal ganglia of patients with Parkinson's disease (PD) are associated with impaired motor performance. Here we test in human adults whether small variations in the timing of movement relative to beta bursts have a critical effect on movement velocity and whether the cumulative effects of multiple beta bursts, both locally and across networks, matter.
Retrograde neurotrophic signaling in rat retinal ganglion cells is transmitted via the ERK5 but not the ERK1/2 pathway.
2014
Purpose Neurotrophic deprivation is considered an important event in glaucomatous retinal ganglion cell (RGC) death. However, the mitogen-activated protein kinase (MAPK) pathway transmitting axonal neurotrophic signals in RGC has not been identified. We investigated the involvement of ERK5 and ERK1/2 in retrograde axonal neurotrophic signaling in rats. Methods Adult Sprague-Dawley rats were used. Retinal immunostaining for ERK5 and MEK5 was performed. Levels of total and phosphorylated ERK5 and ERK1/2 were analyzed in retinal lysate by quantitative Western blotting. The effects of age, brain-derived neurotrophic factor (BDNF) stimulation at RGC soma (intravitreal injection) or axon ending (…
La maschia potenza. Pratiche ergologiche e coreutica rituale nella civiltà contadina
2020
In occasione di diverse celebrazioni religiose che scandiscono il calendario cerimoniale siciliano, in specie nel corso della Settimana Santa e di alcune feste patronali, possibile osservare delle modalità di trasporto dei fercoli processionali (vare) assai peculiari. I santi simulacri, infatti, in tali circostanze, sono fatti correre e danzare sia per le strade dei centri abitati sia, in rari casi, all’interno degli edifici religiosi. Il disordine che connota queste performances coreutiche solo apparente. Esse obbediscono in realtà a un preciso codice cinetico: i fercoli vengono ritmicamente alzati e abbassati sulle braccia dai portatori, roteano ripetutamente su se stessi facendo id…
Casa comunale di Castelvetrano, Trapani
2009
Progetto realizzato e vincitore di numerosi e prestigiosi premi d’architettura.
Biallelic mutations in neurofascin cause neurodevelopmental impairment and peripheral demyelination
2019
See Karakaya and Wirth (doi:10.1093/brain/awz273) for a scientific commentary on this article. Neurofascin (NFASC) isoforms are immunoglobulin cell adhesion molecules involved in node of Ranvier assembly. Efthymiou et al. identify biallelic NFASC variants in ten unrelated patients with a neurodevelopmental disorder characterized by variable degrees of central and peripheral involvement. Abnormal expression of Nfasc155 is accompanied by severe loss of myelinated fibres.
Il procedimento di sorveglianza
2011
Sommario: 1. La collocazione sistematica. Linee evolutive del rito di sorveglianza. – 1.1. La trasposizione codicistica di un modello tipo di rito post iudicatum. – 2. Il modello tipo. L'individuazione dell'ambito applicativo. – 2.1. L'instaurazione del procedimento. – 2.2. Gli atti preliminari: a) la delibazione di ammissibilità della domanda. – 2.3. Segue: b) gli altri adempimenti prodromici alla celebrazione dell'udienza. – 2.4. L'udienza camerale: a) il modello a contraddittorio necessario e l'articolazione delle attività d'udienza. – 2.5. Segue: b) partecipazione del difensore, assenza, legittimo impedimento. – 2.6. Segue: c) l'intervento dell'interessato e i limiti partecipativi impos…
Effect of claustrum stimulation on neurons of the contralateral medial oculomotor area, in the cat
1990
In chloralose-anaesthetized cats, the extracellular spontaneous unitary activity was recorded from 157 neurons, located in the medial oculomotor area. 98 units were identified as projecting onto the superior colliculus. Electrical stimulations of the contralateral claustrum provoked, on 13 of these cells, an excitatory effect, lasting 10-35 ms and appearing with a latency of 20-50 ms. Full length section of the corpus callosum totally abolished the contralateral claustrum effect. The results suggest that in the cat, the claustrum may have a role in the bilateral control of the visuo-motor performance.
The cognitive profile of prion disease: a prospective clinical and imaging study
2015
Objectives Prion diseases are dementing illnesses with poorly defined neuropsychological features. This is probably because the most common form, sporadic Creutzfeldt-Jakob disease, is often rapidly progressive with pervasive cognitive decline making detailed neuropsychological investigation difficult. This study, which includes patients with inherited, acquired (iatrogenic and variant) and sporadic forms of the disease, is the only large-scale neuropsychological investigation of this patient group ever undertaken and aimed to define a neuropsychological profile of human prion diseases. Methods A tailored short cognitive examination of all of the patients (n = 81), with detailed neuropsycho…
The Origin, Location, and Projections of the Embryonic Abdominal Motorneurons ofDrosophila
1997
We have used a retrograde labeling technique to identify motorneurons for each of the 30 body wall muscles of an abdominal hemisegment in the late stage 16Drosophilaembryo. Each motorneuron has a characteristic cell body position, dendritic arborization, and axonal projection. In addition, we have determined the neuroblasts of origin for most of the motorneurons we describe. Some organizational principles for the neuromuscular system have become apparent: (1) There is no obvious topographic relationship between the cell body positions of motorneurons and the position or orientation of the muscles they innervate; (2) motorneurons that innervate muscles of similar position and orientation are…