Search results for "graves"
showing 10 items of 128 documents
Stimulatory Thyrotropin Receptor Antibodies Are a Biomarker for Graves' Orbitopathy.
2021
Risonanza magnetica DWI nei pazienti affetti da Orbitopatia di Graves.
2015
Archaeology, chronology, and age-diet insights of two late fourth millennium cal BC pit graves from central southern Iberia (Córdoba, Spain)
2020
This study presents the isotopic ratios, radiocarbon datings, and anthropological analyses of five (N = 5) Early Copper Age individuals from two archaeological sites (Arruzafa and Iglesia Antigua de Alcolea) of the Middle Guadalquivir Valley near the city of Córdoba (Spain). Four had been buried in the same grave, possibly in a single event or in a very short time lapse. The collagen residue analyses of the individuals offer δC values ranging between −20.08 and −18.4 and δN values between 8.57 and 11.15. The findings indicate that the infant and the elderly had, respectively, the richest and poorest animal protein diets, the first likely as a result of nursing. The combined study of these f…
Efficacy and safety of preoperative with Lugol's iodine solution euthyroid patients with Graves' disease (LIGRADIS Trial): study protocol for a multi…
2021
"Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM"
Steroids Are Effective for Preventing Post-RAI Graves’ Orbitopathy In Those with Graves’ Disease of <5 Years’ Duration
2020
Immunotherapies for thyroid eye disease
2019
Thyroid eye disease is a complex autoimmune disorder which causes substantial morbidity. It can result in orbital disfigurement, double vision, and visual loss. Consequently, it has a substantial negative effect on quality of life, mental health, and socioeconomic status. Most signs and symptoms of thyroid eye disease (TED) can be explained by the expansion of the orbital contents. Steroids are the mainstay of treatment in TED. However, recurrence may occur once steroids are withdrawn. Furthermore, in most cases, normal orbital anatomy is not restored, and skilled rehabilitative surgery is required to reduce disfigurement, double vision, and to preserve vision. Therefore, novel, causal, and…
Glucocorticoids in Graves’ orbitopathy: mechanisms of action and clinical application
2020
Background:Graves’ orbitopathy (GO) is the most frequent extrathyroidal manifestation of the autoimmune Graves’ disease. GO significantly impacts quality of life and has a psycho-social morbidity. Inflammation and swelling of the orbital tissue often leads to proptosis, diplopia, and decrease of visual acuity. Due to the inflammatory background of the disease, glucocorticoids (GC) have been used as a first-line treatment for decades.Methods:PubMed and MeSH database were searched for original articles, clinical trials, reviews, and meta-analyses published between 1 January 2000 and 31 March 2020 and pertaining to both the mechanism of action and immunological effects of GC as well as to the …
Future Research in Graves' Orbitopathy: From Priority Setting to Trial Design Through Patient and Public Involvement
2015
Graves' orbitopathy (GO) is a disfiguring autoimmune condition, which can sometimes cause blindness (1). The disease has profound effects on quality of life (2), psychological health (3), and socioeconomic status (4). Progress in understanding and treating this disease has been slow. However, recent advances include delineation of plausible immunological mechanisms (5), development of an animal model (6), and publication of randomized studies defining the role and limitations of intravenous steroids (7), rituximab (8,9), and selenium (10). Yet, some of this knowledge remains to be translated into improvement in clinical care. Access of patients to specialist treatments is patchy and seems t…
CHILD INHUMATIONS ON THE ISLAND OF MOTYA. NEW EVIDENCE FROM THE ARCHAIC CEMETERY
2020
The aim of this paper is to shed light on the interpretation of human remains and funerary rituals recently uncovered in the Archaic Necropolis of Motya. During the 20th century about 350 graves were brought to light by earlier explorations, showing that – apart from rare exceptions – adult cremation was the most common rite performed in archaic times (ca. 730-550 BC). This picture can be now changed in the light of the results of our recent fieldwork (seasons 2013-2017), showing that a large quantity of graves strikingly house remains of sub-adult individuals (i.e. foetuses, perinatals and children). While a few of them are cremated, the numerous inhumations recovered show clear patterns o…
The lacrimal gland herniation role in the Graves’ orbitopathy
2017
To evaluate the LG involvement, through the measurement of the LG herniation by of magnetic resonance imaging (MRI), in patients with different GO activity