Search results for "guinea"

Anticomplementary Activity of Guinea Pig Serum Euglobulin: Its Relation to C 1 and to TAMe Esterase

1969

The interaction of complement with a suitable antigen-antibody aggregate triggers a chain of chemical reactions involving consecutively the nine factors of complement (C1 to C9). The triggering reaction is identical with the material fixation of Cl to the immune complex ; this leads to the formation of Ag-Ab-C1. By its fixation Cl is converted from its chemically inert form to a highly reactive state (“fixed” or “activated” C1). The reactivity of fixed Cl is directed first against C4. Consequently C4 rapidly disappears from the fluid phase in the presence of fixed Cl. A strikingly similar process occurs spontaneously in a fraction of guinea pig serum [5, 6].

Linkage of C4 and C4 deficiency to BF and GPLA

1977

The C4, Bf, and GPLA phenotypes of homo- and heterozygous C4-deficient guinea pigs were studied. The electrophoretic patterns suggest that the deficiency in circulating C4 results from an impaired structural gene, allelic to the C4F, C4S, and C4S1 alleles at the C4 locus. In family studies, support for linkage of C4 and Bf to theGPLA system was obtained. The defective gene appears to be the fourth allele, which is rare, in the polymorphism of the fourth component of guinea pig complement.

�ber die Wirkung von Calcium und Natrium auf die Kaliumkontraktur isolierter Meerschweinchenvorh�fe

1969

An isolierten linken Meerschweinchenvorhofen wurde der Einflus von Calcium und Natrium auf das Verhalten der Kaliumkontraktur und des Membranpotentials mit folgenden Ergebnissen untersucht: Die Ergebnisse zeigen, das sich die Kontraktur des Meerschweinchenvorhofs in ihrem Verlauf und ihrer Beeinflusbarkeit durch Calcium und Natrium nicht grundsatzlich von der des Froschherzens unterscheidet. Daraus wird geschlossen, das ihr in beiden Fallen der gleiche Mechanismus zugrunde liegt.

Vergleich der subcellulären Verteilung von 3H-Strophanthin und 3H-Digi-toxin im Meerschweinchenherzen / Comparison of the Subcellular Distribution of…

1969

Um Aufschlus uber den Wirkort von Herzglykosiden in der Herzmuskelzelle zu erhalten, wurde die subcellulare Verteilung von 3H-Digitoxin und 3H-Strophanthin untersucht und mit dem positiv inotropen Effekt verglichen. Meerschweinchenherzen wurden nach der Langendorff-Methode mit glykosidhaltiger Tyrodelosung (3 · 10−7 bzw. 2,8 · 10−7 g/ml; 37°C) perfundiert; die Kontraktionskraft wurde fortlaufend isotonisch registriert. Die Glykosidkonzentration in den einzelnen Fraktionen wurde nach Homogenisation, Differentialzentrifugation und Extraktion der Glykoside mit Toluol bzw. Dioxan mit einem Flussigkeitsszintillations-zahlgerat bestimmt. Die Ruckverteilung wahrend der Aufarbeitung wurde in Kontro…

Tinea imbricata in Papua-Neuguinea: Behandlungsversuch mit Griseofulvin und Haloprogin bei einer Population des Gogol-Valley, Madang Province

2009

Zusammenfassung: In zwei Dorfern des Gogol Valley (Papua-Neuguinea) wurden satliche 47 an Tinea imbricata erkrankten Personen erfas, wovon 39 einer Griseofuhin®- bzw. Mycan-den®-Therapie oder Kombination zugefuhrt wurden. Die Zuweisung zu den unterschiedlichen Behandlungsgruppen erfolgte anhand des Alters und des prozentualen Befalls der Korperoberflache. Die Therapiedauer betrug maximal 4 Wochen, der Beobachtungszeitraum insgesamt 6 Wochen. Eine Remission des Hautbefalls erfolgte fur beide Therapeutika von der 2. Behand-lungswoche an. Rezidive traten jedoch schon 1 Woche nach Therapieende auf. Es konnten Unterschiede in der Altersverteilung der Erkrankten in beiden Dorfern festgestellt wer…

Localization of Ca(2+)-stores and tissue compartments with a Ca(2+)-binding capacity in the organ of Corti of the guinea-pig by electron energy-loss …

1992

SUMMARY The addition of 10 mM CaCl2 to glutaraldehyde fixative leads to the formation of small electron-dense deposits in the organ of Corti of the guinea-pig. These precipitates are mainly attached to cell membranes in contact with different extracellular lymphatic fluids. A higher number of precipitates is localized in the acellular parts of tectorial and basilar membrane. Electron energy-loss spectroscopy (EELS) was used to determine the elemental composition of the deposits formed. The spectra showed a prominent signal at the Ca2+ L2,3 ionization edge. Oxygen could also be detected in all the precipitates analysed. EELS analysis of mitochondria of the inner and outer hair cells after co…

Possible Ca 2+ -dependent mechanism of apical outer hair cell modulation within the cochlea of the guinea pig

1998

Calcium ions were precipitated with potassium antimonate after injection of the inorganic calcium channel blocker MnCl2 or the inorganic potassium channel blockers BaCl2 or CsCl into the perilymph of the scala vestibuli of the guinea pig. The spatial distribution of the formed histochemical reaction products within the organ of Corti was studied by energy-filtering transmission-electron microscopy. Compared with untreated control ears, the number of the formed precipitates drastically increased at the extracellular side of the lamina reticularis after application of the various inorganic channel blockers. The apical side of the outer hair cells and the intervening Deiter cells were covered …

Ocurrence of enteroparasites with zoonotic potential in animals of the rural area of San Andres, Chimborazo, Ecuador.

2021

Abstract Objective The aim of this research was the identification of the enteroparasites harbored by the animals of the San Andres community, to evaluate their role as susceptible hosts and sources of infection for other animals, humans (zoonoses), as well as parasite forms spreaders to the environment in this rural area, located in the province of Chimborazo, Ecuadorian Andean region. Material and methods The study was carried out combining 3 coproparasitological techniques: direct examination, Ritchie and Ziehl-Neelsen in 300 animal stool samples Results Blastocystis sp., Entamoeba spp., Giardia spp., Balantidium spp., Cryptosporidium spp., Ascaris spp., Toxocara spp., Ancylostoma spp., …

Biochemical, morphological, and functional aspects of systemic and local vitamin A deficiency in the respiratory tract.

1992

Effect of serotonin and calcium in normal and sensitized guinea pig isolated trachea

1996

Tracheal strips from normal and actively sensitized guinea pigs were studied to determine the responses to serotonin (5-hydroxytryptamine, 5-HT ; 1 nM - 0.1 mM) and ouabain (0.1 μM - 0.1 mM), and the effects of increasing the extracellular calcium (Ca o ) concentration on tonic contractions elicited by 5-HT. Sensitized trachea exhibited an increased responsiveness and sensitivity to 5-HT and ouabain. Increases in Ca o to achieve final concentrations of 5, 10 and 20 mM caused concentration-related relaxations of normal and sensitized tissues contracted to a similar plateau level with 5-HT. Inhibition of the Na + /K + -ATPase by ouabain (10 μM) reversed the effects of Ca o from relaxation to …