Search results for "healing"

Endoplasmic reticulum‐resident chaperones modulate the inflammatory and angiogenic responses of endothelial cells

2015

SummaryBackground Wound healing depends on a well-balanced regulation of inflammation and angiogenesis. In chronic wounds the healing process is disturbed and inflammation persists. Regulation of wound closure is controlled by transmembrane and extracellular proteins, the folding and maturation of which occur in the endoplasmic reticulum (ER) by ER-resident chaperone machinery. Objectives To study the role of the ER-resident chaperones BiP/Grp78, its cochaperone Mdg1/ERdJ4, and Grp94 in chronic, nonhealing wounds. Methods Immunohistochemical staining of these chaperones in individual human biopsies and investigation of the possible role of BiP and Mdg1 in endothelial cells, focusing on thei…

Pain reduction by dehydrated human amnion/chorion membrane allograft in nondiabetic leg ulcers might be an early indicator of good response: A case s…

2020

Dehydrated human amnion/chorion membrane allograft (dHACM) derived from placenta is increasingly used for skin and soft tissue repair in several medical specialties. Promising effects of dHACM were also reported in chronic venous and diabetic leg ulcers. However, dHACM is cost-intensive and its effect on chronic leg ulcers of other etiologies and pain reduction is unknown. Clinical predictors of a favorable response to dHACM during the early treatment period could help to limit unnecessary costs. In our case series with six patients suffering from chronic lower leg ulcers of various etiology, the effect of dHACM once per week on reduction of pain and wound size during a 5-week period was ex…

Effects of Probiotics in the Management of Infected Chronic Wounds: From Cell Culture to Human Studies

2019

Background: Chronic wounds are commonly associated with polymicrobial biofilm infections. In the last years, the extensive use of antibiotics has generated several antibiotic-resistant variants. To overcome this issue, alternative natural treatments have been proposed, including the use of microorganisms like probiotics. The aim of this manuscript was to review current literature concerning the application of probiotics for the treatment of infected chronic wounds. Methods: Relevant articles were searched in the Medline database using PubMed and Scholar, using the keywords “probiotics” and “wound” and “injuries”, “probiotics” and “wound” and “ulcer”, “biofilm” and “probiotics” and “wound”,…

Carboxylated-xyloglucan and peptide amphiphile co-assembly in wound healing.

2021

Abstract Hydrogel wound dressings can play critical roles in wound healing protecting the wound from trauma or contamination and providing an ideal environment to support the growth of endogenous cells and promote wound closure. This work presents a self-assembling hydrogel dressing that can assist the wound repair process mimicking the hierarchical structure of skin extracellular matrix. To this aim, the co-assembly behaviour of a carboxylated variant of xyloglucan (CXG) with a peptide amphiphile (PA-H3) has been investigated to generate hierarchical constructs with tuneable molecular composition, structure, and properties. Transmission electron microscopy and circular dichroism at a low c…

The healing from another paradigm: neoshamanisms and its global emergency in the Spanish case

2021

Resumen Entre la multitud de medicinas y terapias alternativas presentes en el mundo Occidental, el neochamanismo es una de las que, en la actualidad, ha despertado mayor interés y que se sitúa entre las nuevas formas espirituales y los procesos de patrimonialización fruto de la modernidad globalizada. En este artículo se muestra el proceso de reconfiguración de prácticas y conocimientos ancestrales, -etiquetados como chamánicos- y cómo éstos constituyen una respuesta adaptativa en la búsqueda de nuevos espacios vitales y de experiencias colectivas que den sentido a la existencia en el contexto occidental. Desde el caso español y tomando la Comunidad Valenciana como unidad de análisis, nos …

Electrically conductive hydrogel composites made of polyaniline nanoparticles and poly(N-vinyl-2-pyrrolidone)

2006

Abstract A novel electrically conductive composite material, consisting of polyaniline (PANI) nanoparticles dispersed in a polyvinyl pyrrolidone (PVP) hydrogel, was prepared ‘in situ’ by water dispersion polymerisation (DP) of aniline using PVP as steric stabiliser, followed by γ-irradiation induced crosslinking of the PVP component. Conversion yield of aniline into PANI particles was determined via HPLC and gas chromatography, while structural confirmation of the synthesised polymer was sought by FTIR. Morphology and dimensions of PANI particles into the coloured, optically transparent hydrogel was determined by electronic microscopy; moreover, swelling behaviour of composite hydrogels in …

Functional Changes in the Family of Type 3 Copper Proteins During Evolution

2004

Volumetric changes in alveolar ridge preservation with a compromised buccal wall: a systematic review and meta-analysis.

2020

Background Many studies have addressed socket preservation, though fewer publications considering buccal wall loss can be found, since the literature typically considers sockets with four walls. A systematic review was made on the influence of type II buccal bone defects, according to Elian’s Classification, in socket grafting materials upon volumetric changes in width and height. Material and Methods An electronic and manual literature search was conducted in accordance to PRISMA statement. The search strategy was restricted to randomized controlled trials (RCTs) and controlled clinical trials (CCTs) describing post-extraction sockets with loss of buccal wall in which alveolar ridge preser…

Fabrication of quercetin and curcumin bionanovesicles for the prevention and rapid regeneration of full-thickness skin defects on mice

2013

In the present work biocompatible quercetin and curcumin nanovesicles were developed as a novel approach to prevent and restore skin tissue defects on chronic cutaneous pathologies. Stable and suitable quercetin- and curcumin-loaded phospholipid vesicles, namely liposomes and penetration enhancer-containing vesicles (PEVs), were prepared. Vesicles were made from a highly biocompatible mixture of phospholipids and alternatively a natural polyphenol, quercetin or curcumin. Liposomes were obtained by adding water, while PEVs by adding polyethylene glycol 400 and Oramix®CG110 to the water phase. Transmission electron microscopy, cryogenic-transmission electron microscopy and small- and wide-ang…

Un-rooted grafted cuttings for eggplant plug-transplant production and shipping: simulated transportation and healing requirements

2019

Vegetable grafting is one of the most effective eco-friendly techniques to overcome pests and soilborne diseases in modern cropping systems of fruiting vegetables. Due to the increased farmers’ preference for grafted seedlings of high quality and better performance, the use of vegetable grafted plants is rapidly spreading and expanding over the world and intensive researches on new commercial production systems are under way. However, in many areas of the world, due to the high cost of skilled manpower, the use of grafted plug plants is still limited causing a relatively slow development of the grafting nursery industry. The aim of this work was to evaluate a possible use of un-rooted graft…