Search results for "help"

showing 10 items of 318 documents

T Cell Polarization toward T

2016

IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder involving virtually every organ with a risk of organ dysfunction. Despite recent studies regarding B cell and T cell compartments, the disease’s pathophysiology remains poorly understood. We examined and characterized subsets of circulating lymphocytes in untreated patients with active IgG4-RD. Twenty-eight consecutive patients with biopsy-proven IgG4-RD were included in a prospective, multicentric study. Lymphocytes’ subsets were analyzed by flow cytometry, with analysis of TH1/TH2/TH17, TFH cells, and cytokine release by peripheral blood mononuclear cells. Results were compared to healthy controls and to patients with primary…

T helper cellsSjögren’s syndromeImmunologyT follicular helper cellsplasmablastsIgG4-related diseaseOriginal ResearchFrontiers in immunology
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STAT3 activation: A key factor in tumor immunoescape.

2012

Cancer growth is controlled by cancer cells (cell intrinsic phenomenon), but also by the immune cells in the tumor microenvironment (cell extrinsic phenomenon). Thus cancer progression is mediated by the activation of transcription programs responsible for cancer cell proliferation, but also induced proliferation/activation of immunosuppressive cells such as Th17, Treg or myeloid derived suppressor cells (MDSCs). One of the key transcription factors involved in these pathways is the signal transducer and activator of transcription 3 (STAT3). In this review we will focus on STAT3 activation in immune cells, and how it impacts on tumor progression.

T helpersMDSCReviewimmune responseSTAT3Immune systemMedicinecancerdendritic cellsSTAT3Transcription factorTumor microenvironmentbiologybusiness.industryGeneral MedicinemacrophagesTregTumor progressionCancer cellImmunologyMyeloid-derived Suppressor CellSTAT proteinbiology.proteinCancer researchTh17businessJAK-STAT
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An innate cell-mediated, murine ulcerative colitis-like syndrome in the absence of nuclear factor of activated T cells.

2004

Abstract Background & Aims: Nuclear factor of activated T cells transcription factors plays a central role in immunity by regulating the expression of multiple cytokines and other regulatory molecules, many of which have been heavily implicated in the pathogenesis of inflammatory bowel disease. However, few studies have directly investigated the nuclear factor of activated T cells proteins in inflammatory bowel disease. We describe here a specific role for nuclear factor of activated T cells c2 in the pathogenesis of murine inflammatory bowel disease. Methods: Mice deficient for nuclear factor of activated T cells c2, recombinase activating gene-2, or both and transgenic or nontransgenic fo…

T-LymphocytesBiologyInterleukin 21MicemedicineImmune ToleranceCytotoxic T cellAnimalsIL-2 receptorB-LymphocytesImmunity CellularMice Inbred BALB CHepatologyNFATC Transcription FactorsZAP70Innate lymphoid cellGastroenterologyNuclear ProteinsT helper cellRectal ProlapseNatural killer T cellAcquired immune systemMice Mutant StrainsDNA-Binding ProteinsMice Inbred C57BLmedicine.anatomical_structureImmunologyCancer researchColitis UlcerativeTranscription FactorsGastroenterology
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Verkkosivustojen omaksumiseen vaikuttavat tekijät

2016

Tässä tutkielma käsiteltiin verkkosivustojen omaksumista ja siihen vaikuttavia tekijöitä. Tutkielmassa tutustuttiin aluksi teknologian omaksumiseen yleisellä tasolla, ja syvennyttiin sitten tarkemmin verkkosivustoihin. Teoreettinen tausta pohjautui teknologian omaksumisen malliin (Technology Acceptance Model, TAM), joka esittää, että kaksi tärkeintä teknologian omaksumista selittävää teki-jää ovat käyttäjän kokema hyödyllisyys ja helppokäyttöisyys. Teknologian omaksumisen tutkimus on olennaista teknologian suunnitteluprosessissa, sillä ymmärrys siihen vaikuttavista tekijöistä voi helpottaa suunnittelijoita kehittämään helpommin hyödyllisiksi ja helppokäyttöisiksi koettuja tuotteita ja palve…

TAMhelppokäyttöisyyshyödyllisyysTeknologian omaksuminenverkkosivustotkäyttäjäkokemus
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Infectious Tolerance

2002

Regulatory CD4(+)CD25(+) T cells (Treg) are mandatory for maintaining immunologic self-tolerance. We demonstrate that the cell-cell contact-mediated suppression of conventional CD4(+) T cells by human CD25(+) Treg cells is fixation resistant, independent from membrane-bound TGF-beta but requires activation and protein synthesis of CD25(+) Treg cells. Coactivation of CD25(+) Treg cells with Treg cell-depleted CD4(+) T cells results in anergized CD4(+) T cells that in turn inhibit the activation of conventional, freshly isolated CD4(+) T helper (Th) cells. This infectious suppressive activity, transferred from CD25(+) Treg cells via cell contact, is cell contact-independent and partially medi…

TGF-βCD4-Positive T-Lymphocyteshuman regulatory T cellsT-LymphocytesImmunologyCellchemical and pharmacologic phenomenaIn Vitro TechniquesLymphocyte ActivationT-Lymphocytes RegulatoryImmune toleranceInterleukin 21AntigenTransforming Growth Factor betaCD4+CD25+ T cellsCell AdhesionImmune TolerancemedicineHumansImmunology and AllergyCytotoxic T cellIL-2 receptorbiologyBrief Definitive ReportModels ImmunologicalReceptors Interleukin-2hemic and immune systemsT-Lymphocytes Helper-InducerTransforming growth factor betainfectious tolerancemedicine.anatomical_structureT cell inhibitionImmunologyCancer researchbiology.proteinTransforming growth factorJournal of Experimental Medicine
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La scoperta, sistemazione e conservazione della grande Iscrizione di Gortina, nell'isola di Creta (1884-1921): la protezione delle testimonianze e le…

2013

La scoperta e la conservazione della Grande Iscrizione di Gortina a Creta, da parte degli studiosi italiani, fra la fine del XIX sec. e i primi decenni del XX sec., rappresentò un grande riconoscimento scientifico-culturale per la giovane nazione italiana. Nel passato, l’isola di Creta era stata legata alla Repubblica di Venezia e anche questo rapporto favorì l’invio a Creta del giovane epigrafista F. Halbherr, il quale fra notevoli peripezie rinvenne, assieme all’epigrafista tedesco E. Fabricius, la famosa l’iscrizione nell’antica città di Gortina. L’iscrizione, fra le più antiche e complete finora conosciute in tutta Europa, conteneva le norme sulla famiglia, l’eredità e in generale i dir…

The discovery and preservation of the Great Inscription of Gortyna in Crete by Italian researchers in the late nineteenth century. and the first decades of the twentieth century. was an important cultural and scientific recognition for the young Italian nation. In the past the island of Crete had been tied to the Republic of Venice and this report also favored sending in Crete the young epigraphist F. Halbherr who among considerable vicissitudes came to together to the epigraphist german E. Fabricius the inclusion of the famous ancient city of Gortyna. The inscription among the oldest and most comprehensive so far known throughout Europe the rules contained on the family's legacy in general and the rights and duties of some of the people of the Minoan civilization (480-450 BC). The inscription was carved on blocks organic limestone a restored ancient building which later in Roman times was turned into odeon. The Laws of Gortyn were engraved on the remains of the wall forming the passageway in front of the steps of the odeon. The essay traces the events that led to the discovery and subsequent storage made by Halbherr especially with the help of archaeologist L. Pernier and finally with the help of architect E. Stefani who designed a modern cover on the top of the ambulatory of the segments containing the inscription. This coverage was made to perform during the First World War on the basis of the Italian project from the Greek Government in order to protect the membership from possible war damage but especially from vandalism. The roof brick clay of the Laws of Gortyna still serves its function and ensures the use of the monument bearing witness to the preservation of Italian culture in Greece and more generally in the world. But in Sicily in the remains of the Villa del Casale in Piazza Armerina (Enna) its elegant protection (built in 1957) is representative of a whole period of culture of the Italian restoration is removed and replaced because it has not been able to make a ongoing maintenance is due. A bad example of conservation and management of a UNESCO monument from which arise after the work for the construction of new roofs an equally insulting to the archaeological heritage and scenic Italian and world.Settore ICAR/19 - Restauro
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Tommaso Maria Napoli Utriusque Architecturae Compendium Roma 1688 Breve trattato sulle fabbriche civili e militari e la conservazione delle architett…

2013

Il volume Tommaso Maria Napoli Utriusque Architecturae Compendium Roma 1688 Breve trattato sulle fabbriche civili e militari e la conservazione delle architetture del frate domenicano Tommaso Maria Napoli, vuole contribuire ad accrescere le nostre conoscenze sui principi che dovevano sottendere alla realizzazione dell’architettura civile e militare del periodo barocco e tardo barocco, così come espressi nel breve trattato scritto dal frate architetto, nato a Palermo, Tommaso Maria Napoli (1659-1725), e pubblicato a Roma alla fine del Seicento. Alla traduzione dal latino del trattato, redatta da esperti (Fabio Zarbo e Pietro Zarbo), è inclusa un’interessante ricerca, redatta congiuntamente c…

The volume Tommaso Maria Napoli Utriusque Architecturae Brief Compendium 1688 Rome treaty on civil and military factories and preservation of the architecture of the Dominican friar Tommaso Maria Napoli wants to help increase our understanding of the principles that should underpin the realization of civil and military baroque and late baroque period as expressed in the short treatise written by the monk architect born in Palermo Tommaso Maria Napoli (1659-1725) and published in Rome at the end of the seventeenth century. This translation from the Latin of the treaty drawn up by experts (Fabio Zarbo e Pietro Zarbo) included is an interesting research drafted jointly with Giuseppe Tantillo status of some of the architecture without realizing or attributed to the architect Tommaso Maria Napoli. In fact some cards are attached to the volume on the substance and state of preservation of the cathedral of the Assumption of Mary in Dubrovnik (Croatia) of the villas Valguarnera and Palagonia in Bagheria (near Palermo Italy) of the monument to the Immaculate and one of the towers of the church of San Domenico in Palermo (Italy). The volume is enriched by the presentation and afterword by Francesco Tomaselli that among other things starting from the definition of Restoration expressed by Tommaso Maria Napoli in his book presents a stimulating reflection on the meaning of Restoration. The essay Tommaso Maria Napoli Utriusque Architecturae Compendium 1688 ... is the first of the series Monument Document for the conservation of the architectural heritage and environment: Theory knowledge interventions publisher Aracne in Rome with director Francesco Tomaselli and with Comittee Scientific and editorial international.Settore ICAR/19 - Restauro
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T-bet and mucosal Th1 responses in the gastrointestinal tract

2002

T cells play an essential role in regulating mucosal immune responses in the gastrointestinal tract. Recent observations on T helper cell differentiation and activation by regulatory transcription factors-especially T-bet-in chronic inflammatory diseases have provided new perspectives for understanding mucosal immunity. Here we summarise recent advances in the field of transcription factors and discuss the implications of these findings for future therapeutic approaches in inflammatory bowel diseases. In particular, we have focused on the role of T-bet in controlling mucosal Th1 responses in the gastrointestinal tract.

Transcription GeneticCellular differentiationGene Expressionchemical and pharmacologic phenomenaInflammationLeading ArticleBiologyInterferon-gammaMiceImmune systemImmunopathologymedicineAnimalsHumansT-helper cell differentiationImmunity MucosalTranscription factorImmunity CellularGastrointestinal tractT-cell receptorGastroenterologyCell DifferentiationTh1 CellsInflammatory Bowel DiseasesGastric MucosaImmunologyCytokinesmedicine.symptomT-Box Domain ProteinsDigestive SystemInterleukin-1Transcription FactorsGut
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Development, Differentiation, and Diversity of Innate Lymphoid Cells

2014

Recent years have witnessed the discovery of an unprecedented complexity in innate lymphocyte lineages, now collectively referred to as innate lymphoid cells (ILCs). ILCs are preferentially located at barrier surfaces and are important for protection against pathogens and for the maintenance of organ homeostasis. Inappropriate activation of ILCs has been linked to the pathogenesis of inflammatory and autoimmune disorders. Recent evidence suggests that ILCs can be grouped into two separate lineages, cytotoxic ILCs represented by conventional natural killer (cNK) cells and cytokine-producing helper-like ILCs (i.e., ILC1s, ILC2s, ILC3s). We will focus here on current work in humans and mice th…

Transcription GeneticLymphocyteCellular differentiationImmunologyBiologyArticleTight Junctions03 medical and health sciencesMice0302 clinical medicinemedicineTranscriptional regulationCytotoxic T cellImmunology and AllergyAnimalsHumansCell Lineageskin and connective tissue diseases030304 developmental biologyRegulation of gene expression0303 health sciencesStem CellsInnate lymphoid cellCell DifferentiationT-Lymphocytes Helper-InducerImmunity InnateKiller Cells Naturalbody regionsMulticellular organismmedicine.anatomical_structureInfectious DiseasesGene Expression RegulationImmunologyCytokinesStem cell030215 immunologySignal TransductionImmunity
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On norm attaining operators and multilinear maps

2014

El principal punto de interés de esta tesis es el estudio de extensiones de los teoremas de Bishop-Phelps y Bishop-Phelps-Bollobás a diferentes contextos. Esta tesis se divide en tres capítulos. En el primero hacemos un repaso de la teoría de funcionales que alcanzan la norma. En este resumen introducimos el Teorema de Bishop-Phelps y el Teorema de Bishop-Phelps-Bollobás. El segundo capítulo está dedicado al estudio de extensiones de los resultados de Bishop-Phelps y Bishop-Phelps-Bollobás al caso de operadores. En la sección 2.2 estudiaremos la extensión de estos resultados al caso de operadores desde el punto de vista de alcanzar el radio numérico, para concluir en la sección 2.3.1 que el…

UNESCO::MATEMÁTICAS::Análisis y análisis funcional::Algebras y espacios de BanachBanachBishop-PhelpsBishop-Phelps-BollobásMultilineales:MATEMÁTICAS::Análisis y análisis funcional::Algebras y espacios de Banach [UNESCO]Radio numéricoAlcanzar la norma
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