Search results for "hepatectomy"

Fractionated External Beam Radiotherapy as a Suitable Preparative Regimen for Hepatocyte Transplantation After Partial Hepatectomy

2010

Purpose Hepatocyte transplantation is strongly considered to be a promising option to correct chronic liver failure through repopulation of the diseased organ. We already reported on extensive liver repopulation by hepatocytes transplanted into rats preconditioned with 25-Gy single dose selective external beam irradiation (IR). Herein, we tested lower radiation doses and fractionated protocols, which would be applicable in clinical use. Methods and Material Livers of dipeptidylpeptidase IV (DPPIV)-deficient rats were preconditioned with partial liver external beam single dose IR at 25 Gy, 8 Gy, or 5 Gy, or fractionated IR at 5 × 5 Gy or 5 × 2 Gy. Four days after completion of IR, a partial …

Epigenetic Transcriptional Regulation of the Growth Arrest-Specific gene 1 (Gas1) in Hepatic Cell Proliferation at Mononucleosomal Resolution

2011

Background Gas1 (growth arrest-specific 1) gene is known to inhibit cell proliferation in a variety of models, but its possible implication in regulating quiescence in adult tissues has not been examined to date. The knowledge of how Gas1 is regulated in quiescence may contribute to understand the deregulation occurring in neoplastic diseases. Methodology/Principal Findings Gas1 expression has been studied in quiescent murine liver and during the naturally synchronized cell proliferation after partial hepatectomy. Chromatin immunoprecipitation at nucleosomal resolution (Nuc-ChIP) has been used to carry out the study preserving the in vivo conditions. Transcription has been assessed at real …

Analysis of the Effects of Modifying Agents on Six Different Phenotypes in Preneoplastic Foci in the Liver in Medium-Term Bioassay Model in Rats

1988

Recently a great deal of interest has been expressed in characterizing the altered enzyme phenotype of putative preneoplastic rat liver lesions. In particular, attention has been given to the changes in drug metabolizing potential, conferring physiological advantage to initiated cells, and their usefulness as marker lesions for the analysis of the development of neoplasia1–2.

Peri-Operative Liver Regeneration of the Remnant Liver Volume after Right Hepatectomy for Living Donation: A Multiple Regression Analysis

2012

Early liver regeneration was studied in a series of 70 patients who underwent right hepatectomy for living donation from November 2004 to January 2010. Liver regeneration was evaluated by multidetector computed tomography at a mean time of 61.07 days after surgery. Pre-surgical variables such as age, weight, height, body mass index, liver function tests, creatinine, platelet count, international normalized ratio, glucose, and variables detected with preoperative multidetector computed tomography imaging, including diameter of main portal vein, steatosis, original liver volume and spleen volume, were investigated as potential predictors of liver regeneration. Future remnant liver volume was …

Donor/recipient algorithm for management of the middle hepatic vein in right graft live donor liver transplantation

2010

Abstract Background The aim of this study was to delineate an algorithm for donor and recipient criteria and middle hepatic vein (MHV) management in right-graft live-donor liver transplantation (LDLT) on the basis of computerized 3-dimensional computed tomographic image analysis. Methods Data on 94 consecutive right-graft LDLTs were prospectively collected. Graft and remnant data for the first 23 cases were retrospectively evaluated by means of 3-dimensional computed tomographic reconstructions, and on the basis of that preliminary series, a graft selection algorithm using 3 parameters—hepatic vein dominance classification, graft and remnant graft volume/body weight ratios, and congestion v…

Technik der Mesohepatektomie

2016

Bei Patienten mit einer primar oder sekundar malignen zentralen Leberraumforderung stellt die Resektion im Sinne einer erweiterten Hemihepatektomie rechts bzw. links das Standardverfahren dar. Unter Berucksichtigung der erhohten Morbiditat und Mortalitat bei erweiterten Resektionen und dem Aspekt des hohen Verlusts an gesundem Lebergewebe stellt die zentrale Leberresektion oder Mesohepatektomie (Resektion der Segmente 4a/4b, 5 und 8) mit oder ohne Resektion des Segments 1 eine technisch anspruchsvolle und weiterhin selten genutzte Alternative dar. Die Resektionsgrenzen liegen rechtsseitig des Lig. falciforme und auf der oft schwierig zu identifizierenden Grenze zwischen den Segmenten 5/6 so…

Erweiterte Hemihepatektomie links mit Rekonstruktion der rechten Lebervene bei intrahepatischem cholangiozellulärem Karzinom

2016

Die erweiterte Hemihepatektomie links mit der Resektion der Lebersegmente 1, 2, 3, 4 a/b, 5 und 8 ist eine auch weiterhin sehr herausfordernde Leberresektion, deren Indikation bei gut selektionierten Patienten die Chance auf eine kurative Resektion bei primaren oder sekundaren Lebertumoren mit komplizierter Lage bieten kann. Die Morbiditat und Mortalitat ist gegenuber den nicht erweiterten Leberresektionen erhoht. Eine prazise Bildgebung und genaue Operationsplanung unter Berucksichtigung des verbleibenden Lebervolumens sowie von Einflussfaktoren wie Vorschadigungen des Leberparenchyms durch Chemotherapie oder eine Fibrose/Zirrhose ist hierbei unabdingbar. Notwendig wird dieses operative Vo…

Imaging-guided interventions modulating portal venous flow: Evidence and controversies

2021

Portal hypertension is defined by an increase in the portosystemic venous gradient. In most cases, increased resistance to portal blood flow is the initial cause of elevated portal pressure. More than 90% of cases of portal hypertension are estimated to be due to advanced chronic liver disease or cirrhosis. Transjugular intrahepatic portosystemic shunts, a non-pharmacological treatment for portal hypertension, involve the placement of a stent between the portal vein and the hepatic vein or inferior vena cava which helps bypass hepatic resistance. Portal hypertension may also be a result of extrahepatic portal vein thrombosis or compression. In these cases, percutaneous portal vein recanalis…

Another Small Step Forward in ALPPS

2020

ERAS Protocol for Perioperative Care of Patients Treated with Laparoscopic Nonanatomic Liver Resection for Hepatocellular Carcinoma: The ISMETT Exper…

2020

Background: Liver resection (LR) remains the best therapeutic option for patients with early-stage hepatocellular carcinoma (HCC) with preserved hepatic function and who are not eligible for liver transplantation. After its inception, the enhanced recovery after surgery (ERAS) protocol was widely used for treating patients with liver cancer, although there are still no clear indications for improving upon it in both open and laparoscopic surgery. Objective: This study aims to describe our institute's experience in the application of the ERAS protocol in a cohort of HCC patients, and to explore possible factors that could have an impact on postoperative outcomes. Materials and Methods: We re…