Search results for "hip"
showing 10 items of 9327 documents
Cement augmentation for trochanteric fracture in elderly: A systematic review()
2021
Abstract Background Cement augmentation of internal fixation of hip fracture has reported to improve fracture stability in osteoporotic hip fractures, reducing the risk of cut-out of the sliding screw through the femoral head. The purpose of present study was to perform a systematic literature review on the effects of augmentation technique in patients with osteoporotic hip fractures. Material and methods A comprehensive literature search was systematically performed to evaluate all papers published in English language included in the literature between January 2010 and July 2020, according to the PRISMA 2009 guidelines. In vivo and in vitro studies, case reports, review articles, cadaveric…
A pyrroloquinazoline derivative with anti-inflammatory and analgesic activity by dual inhibition of cyclo-oxygenase-2 and 5-lipoxygenase
2002
Abstract In a previous study, we reported a new pyrroloquinazoline derivative, 3-(4′-acetoxy-3′,5′-dimethoxy)benzylidene-1,2-dihydropyrrolo[2,1- b ]quinazoline-9-one (PQ), which inhibited human purified 5-lipoxygenase activity and prostaglandin E 2 release in lipopolysaccharide-stimulated RAW 264.7 cells. In the present work, we show that PQ inhibits cyclo-oxygenase-2 activity in intact cell assays (human monocytes) and purified enzyme preparations (ovine isoenzymes) without affecting cyclo-oxygenase-1 activity. This behaviour was confirmed in vivo by using the zymosan-injected mouse air pouch model, where PQ caused a marked reduction in cell migration and leukotriene B 4 levels at 4 h, as …
A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstituti…
1994
Specific proteolysis by the tetanus toxin light chain of a vesicle-associated membrane protein (VAMP) involved in exocytosis is thought to underlie its intracellular blockade of neurotransmitter release. To substantiate this mechanism, recombinant light chain was expressed as a maltose binding protein-light chain fusion product in Escherichia coli. After purification of affinity chromatography and cleavage with factor Xa, the resultant light chain was isolated and its identity confirmed by Western blotting and N-terminal sequencing. It exhibited activity similar to that of the native light chain in proteolyzing its target in isolated bovine small synaptic vesicles and in hydrolyzing a 62-re…
Descriptive study on subjective experience of genetic testing with respect to relationship, family planning and psychosocial wellbeing among women wi…
2021
AbstractBackgroundDue to increased risk of endometrial and ovarian cancer, women belonging to known Lynch Syndrome (LS) families are recommended to undergo germline testing. Current practice in Finland is to offer counselling to women with pathogenic variant and advocate risk-reducing surgery (RRS) after completion of childbirth. The present study aimed to clarify the impacts of positive germline testing on family planning and reproductive decisions of these women, which are relatively unknown.MethodsSeventy-nine carriers of germline MMR gene pathogenic variant (path_MMR)were identified from the Finnish LS Registry as having genetic testing performed before the age of 45 years and not havin…
Perfluoroalkylated amphiphilic MUC1 glycopeptide antigens as tools for cancer immunotherapy.
2010
The synthesis of perfluoroalkylated glycopeptide antigens and their specific binding to anti-MUC1 mouse antibodies is reported.
Livelli di rappresentazione del testo nell’edizione del De nomine di Orso Beneventano
2018
Viene presentato l’impianto metodologico e tecnologico dell’edizione critica digitale del De nominedi Orso Beneventano (http://www.unipa.it/paolo.monella/ursus), una proof of concept delle innovazioni metodologiche proposte da Tito Orlandi. Il modello qui sperimentato intende superare la dicotomia tra edizione diplomatica e critica grazie ad un ripensamento profondo, semioticamente fondato, dei livelli di trascrizione e di edizione di un testo. I livelli scelti per questa edizione sono: (1) Livello grafematico, le cui unità minime sono i grafemi, inclusi i segni paragrafematici e le brachilogie sistematiche. Tutti i grafemi individuati dall’editore sono elencati nella Graphemic Table of Sig…
What we learn about bipolar disorder from large-scale neuroimaging
2020
Abstract MRI‐derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta‐Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis‐driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Workin…
DAC 6, efficacia dell’accertamento tributario e trasparenza: fino a che punto sono legittimi i doveri di disclosure?
2021
I molteplici interventi sull’originaria struttura della direttiva DAC hanno comportato un notevole ampliamento degli obblighi di informazione fiscalmente rilevanti tanto sotto il profilo soggettivo (ampliamento della platea degli obbligati), quanto sotto quello oggettivo (ampliamento degli obblighi). Ciò induce, in prima battuta, a chiedersi quali possano essere i beni o interessi giuridici tutelati dallo scambio automatico di informazioni fiscalmente rilevanti nel contesto internazionale. Ma induce altresì a domandarsi entro quale misura la tutela di quei beni ed interessi possa legittimare un obbligo di disclosure che attiene non ad un piano domestico dei rapporti fra l’obbligato ed il pr…
Rumor de pañuelo blanco: historia, memoria y representaciones literarias de Abuelas de Plaza de Mayo
2018
El 24 de marzo de 2016 se cumplieron 40 años del golpe de Estado del autodenominado Proceso de Reorganización Nacional que condujo a siete años de una sangrienta dictadura en Argentina. De entre las organizaciones de Derechos Humanos que surgieron como respuesta a las desapariciones ilegales de militantes y de civiles, las Madres y Abuelas de Plaza de Mayo se han constituido, tanto a nivel nacional como internacional, en evidencia de la historia de violencia y en símbolo de paz; como tales también han entrado en el plano de la ficción. Teniendo en cuenta estas líneas, en el presente trabajo se realiza, primero, un recorrido por la historia de las Abuelas de Plaza de Mayo y el cambio polític…
Animación, documental y memoria. La representación animada de la dictadura chilena
2018
Resumen: La animación aparece cada vez más en producciones sobre sucesos relacionados con la memoria. Nuestro objetivo es ana lizar las obras que incorporan escenas animadas para representar la dictadura chilena y profundizar en la convergencia entre animación, documental y memoria. Desde una perspectiva cualitativa, combi namos el análisis de las animaciones con entrevistas a sus directores. Los resultados muestran que la animación es un formato versátil, que permite a los autores superar la ausencia de imágenes de archivo, suavi zar el grado de representación de los suce sos traumáticos, abaratar costes, conectar la memoria con las nuevas generaciones y favorecer la empatía del espectador…