Search results for "histopathology"
showing 10 items of 158 documents
Cytogenetic analysis and metabolic profiling reveal a subgroup of benign meningiomas with chromosomal instabilities and aggressive metabolism
2010
Meningiomas add up to 30% of Central Nervous System (CNS) tumours. Atypical meningiomas show a high index of recurrence 5 years after complete resection. Sometimes, meningiomas with histological diagnosis of benign meningioma show genetics characteristics of atypical meningioma. Aberrations of chromosomes 1, 14, and 22 are the most frequently reported abnormalities in meningiomas. In this communication we used cytogenetic, FISH, and NMR metabolic profiling for a molecular characterization of a series of 46 meningiomas. Tumor samples were obtained from 46 patients with meningioma (36 benign and 12 atypical) from the Clinic Hospital of Valencia. Cytogenetic analyses were performed by short-te…
Hydro-MRT bei entzündlichen Darmerkrankungen - Eine koloskopisch-histologische Vergleichsstudie*
2001
PURPOSE To compare hydro-MRI with colonoscopy and biopsy specimen regarding the assessment of inflammatory activity and the differentiation of inflammatory bowel diseases. MATERIAL AND METHODS After an oral bowel opacification using 1000 ml of a 2.5% mannitol solution and a rectal bowel opacification using 250-500 ml of a 0.9% saline solution, axial and coronal breath-hold sequences +/- Gd-DTPA (HASTE-["half-Fourier acquisition single-shot turbo spin echo"] and dynamic FLASH-["fast low angle shot"]) were acquired in 27 patients with inflammatory bowel disease. The enhancement of the bowel wall as well as morphological MRI findings were correlated with colonoscopy and biopsy specimens. By me…
Synthesis and structural investigations on R2Sn(IV)-D-aldonic acid complexes (R = methyl; butyl). Their effect on a new toxicity test organism,Liza s…
2008
Eight R2Sn(IV)-D-aldonate complexes [(R = Me, Bu; D-aldonate = D-galactonate2− (Galn), D-Gluconate2− (Glun), D-Gulonate2− (Guln), D-Ribonate2− (Ribn)], five of which are new derivatives, have been synthesized and structurally characterized both in solid and solution state by IR, 119Sn Mossbauer and 1H, 13C, 119Sn NMR spectroscopies, showing that ligands act as dianonic chelating agents. In solution phase, NMR data suggest that the bidentate chelation is attained by the O1 carboxylate and the vicinal O2 alkoxide atoms, which can be dynamically extended to a third binding site (O4) competing with O2. In Me2Sn(IV)-D-gluconate complex the occurrence of a self-association process leading to a di…
Hepatitis E Virus Detection in Liver Tissue from Patients with Suspected Drug-Induced Liver Injury
2015
Hepatitis E virus (HEV) infection is increasingly recognized as a cause of acute hepatitis in the industrialized world. We aimed to determine the frequency of acute Hepatitis E virus (HEV) infection in cases of suspected drug-induced liver injury (DILI), mainly a diagnosis of exclusion. To this aim, formalin-fixed, paraffin-embedded (FFPE) liver tissues of all cases routinely processed in our institute during a 2 ½ years period in which DILI was amongst the differential diagnoses (157 liver biopsies, one liver explant) were subjected to semi-nested RT-PCR for the detection of hepatitis E virus (HEV) RNA. Histopathology was re-evaluated on all cases tested positive. HEV RNA was detectable in…
Treatment of giardiasis reverses "active" coeliac disease to "latent" coeliac disease.
2001
In patients with coeliac disease, a regression of intestinal damage without a gluten-free diet is a very rare event. We describe a young child with diarrhoea, intestinal mucosa atrophy and positive serum anti-endomysial and anti-tissue transglutaminase (anti-tTG) antibodies during intestinal giardiasis infection. He showed normal intestinal mucosa architecture and negative anti-endomysial and anti-tTG antibodies after his giardiasis was cured, although he continued to assume a normal diet. Re-evaluations on a 6-monthly basis showed that he was symptom free, and all haemato-chemical parameters were within normal limits. Three years after the initial diagnosis, a third intestinal biopsy showe…
Zur Histopathologie der Niere beim Pseudo-Bartter-Syndrom durch chronischen Diuretikaabusus
1979
Bei einer 38jahrigen Patientin entwickelte sich ein Pseudo-Bartter-Syndrom mit hypokaliamischer Alkalose, Hyponatriamie und Hyperreninamie infolge eines mehr als 10jahrigen Abusus von Diuretika (Furosemid, Spironolacton, Thiabutazid). Als nierenbioptische Befunde werden eine Hyperplasie des iuxtaglomerularen Apparates und der Mesangiumzellen als morphologisches Substrat des Hyperreninismus sowie eine herdformige Vakuolisierung von proximalen Tubuluszellen und eine herdformige Atrophie der distalen Tubuli beschrieben. Die Genese der tubularen Veranderungen und ihre mogliche Beziehung zu kaliopenischen, hypoxischen oder medikamententoxischen Einflussen wird diskutiert, kann jedoch nicht befri…
Úlcera eosinofílica lingual: un reto diagnóstico de patogénesis controvertida
2013
ResumenLa úlcera eosinofílica, también conocida como granuloma ulcerativo traumático con eosinofilia estromal, es una infrecuente y benigna lesión ulcerativa de la mucosa oral que presenta una evolución persistente, planteando a menudo diferentes diagnósticos clínicos diferenciales. Su diagnóstico se establece solo a partir del estudio histopatológico, si bien su morfología presenta a menudo características que pueden sugerir al patólogo la existencia de un proceso linfoproliferativo, traduciendo una patogénesis lesional controvertida todavía no bien aclarada.Comunicamos una observación clínico-patológica de úlcera eosinofílica afectando a una mujer de 76 años de edad. La lesión, de 2,5cm d…
Second trimester uterine arteries pulsatility index is a function of placental pathology and provides insights on stillbirth aetiology: A multicenter…
2022
Introduction: The aim of this study was to investigate the relationships between maternal vascular malperfusions (MVM) and second trimester uterine arteries pulsatility index (UtA-PI) in cases of stillbirth (SB), compared to live-birth (LB) matched controls. Methods: This was a multicentre, observational, matched case-control study performed at five referral maternity centres over a 4-year period including SB and LB control pregnancies at high-risk for preeclampsia (PE) and/or fetal growth restriction (FGR), matched and stratified for UtA-PI MoM quartiles values of the SB cases. Logistic regression was used to assess the rates of each MVM finding, within each increasing MoM quartile subcate…
Eosinophilic ulcer tongue: a diagnostic challenge controversial pathogenesis
2013
La úlcera eosinofílica, también conocida como granuloma ulcerativo traumático con eosinofilia estromal, es una infrecuente y benigna lesión ulcerativa de la mucosa oral que presenta una evolución persistente, planteando a menudo diferentes diagnósticos clínicos diferenciales. Su diagnóstico se establece solo a partir del estudio histopatológico, si bien su morfología presenta a menudo características que pueden sugerir al patólogo la existencia de un proceso linfoproliferativo, traduciendo una patogénesis lesional controvertida todavía no bien aclarada. Comunicamos una observación clínico-patológica de úlcera eosinofílica afectando a una mujer de 76 años de edad. La lesión, de 2,5 cm de diá…
Diagnostic Performance of Multiparametric Magnetic Resonance Imaging and Fusion Targeted Biopsy to Detect Significant Prostate Cancer
2017
Background/aim Multiparametric magnetic resonance imaging combined with ultrasound-fusion-targeted biopsy of the prostate intends to increase diagnostic precision, which has to be clarified. Patients and methods We performed multiparametric magnetic resonance imaging followed by ultrasound-fusion-guided perineal biopsy in 99 male patients with elevated prostate-specific-antigen and previous negative standard biopsy-procedures. Results In 33/99 patients (33%) no malignancy could be confirmed by histopathology. Low-grade carcinomas (Gleason-Score 6+7a) were found in 42/66 (64%) and high-grade carcinomas (Gleason-Score ≥7b) in 24/66 (36%) men. A high-grade carcinoma corresponded to PI-RADS 4 o…