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RESEARCH PRODUCT

Diagnostic Performance of Multiparametric Magnetic Resonance Imaging and Fusion Targeted Biopsy to Detect Significant Prostate Cancer

Thomas SteinArnd GerhardsKarlheinz LeyendeckerKasra TaymoorianFrank M JakobsManuela A HoffmannChristian RufMathias Schreckenberger

subject

Image-Guided BiopsyMaleCancer Researchmedicine.medical_specialty030232 urology & nephrologyMalignancySensitivity and Specificity03 medical and health sciencesProstate cancer0302 clinical medicineProstateBiopsymedicineCarcinomaHumansEndoscopic Ultrasound-Guided Fine Needle AspirationMultiparametric Magnetic Resonance ImagingAgedAged 80 and overmedicine.diagnostic_testbusiness.industryProstateProstatic NeoplasmsReproducibility of ResultsMagnetic resonance imagingGeneral MedicineMiddle AgedProstate-Specific Antigenmedicine.diseaseMagnetic Resonance Imagingmedicine.anatomical_structureOncology030220 oncology & carcinogenesisHistopathologyRadiologyNeoplasm Gradingbusiness

description

Background/aim Multiparametric magnetic resonance imaging combined with ultrasound-fusion-targeted biopsy of the prostate intends to increase diagnostic precision, which has to be clarified. Patients and methods We performed multiparametric magnetic resonance imaging followed by ultrasound-fusion-guided perineal biopsy in 99 male patients with elevated prostate-specific-antigen and previous negative standard biopsy-procedures. Results In 33/99 patients (33%) no malignancy could be confirmed by histopathology. Low-grade carcinomas (Gleason-Score 6+7a) were found in 42/66 (64%) and high-grade carcinomas (Gleason-Score ≥7b) in 24/66 (36%) men. A high-grade carcinoma corresponded to PI-RADS 4 or 5 (suspected malignancy) in 21/24 cases, which accounted for a sensitivity of 88% and negative-predictive-value of 85% (p=0.002). Differentiation between high-/low-grade carcinomas (Gleason-Score ≤7a vs. ≥7b) by means of PI-RADS related to a sensitivity of 88% and a negative-predictive-value of 70% (p=0.74). Conclusion The results support the view that multiparametric magnetic resonance imaging/ultrasound-fusion-guided biopsy promotes considerably higher detection rates of clinically relevant prostate malignancies than do conventional diagnostic procedures. With regard to differentiation between high- and low-grade carcinomas, no significant difference was demonstrated.

yearjournalcountryeditionlanguage
2017-12-03Anticancer Research
https://doi.org/10.21873/anticanres.12149