Search results for "iNOS"
showing 10 items of 2075 documents
Precise measurement of the top quark mass in dilepton decays using optimized neutrino weighting
2016
We measure the top quark mass in dilepton final states of top-antitop events in proton-antiproton collisions at sqrt(s) = 1.96 TeV, using data corresponding to an integrated luminosity of 9.7 fb^-1 at the Fermilab Tevatron Collider. The analysis features a comprehensive optimization of the neutrino weighting method to minimize the statistical uncertainties. We also improve the calibration of jet energies using the calibration determined in top-antitop to lepton+jets events, which reduces the otherwise limiting systematic uncertainty from the jet energy scale. The measured top quark mass is mt = 173.32 +/- 1.36(stat) +/- 0.85(syst) GeV.
Análisis del comportamiento espacio-temporal intradestino mediante GPS : Una aproximación de los visitantes independientes de crucero en la ciudad de…
2020
El presente trabajo tiene como objetivo profundizar en el análisis de los patrones de comportamiento espacio-temporal de los visitantes en destino, una escala de trabajo insuficientemente desarrollada. La investigación aplica un enfoque multimétodo, que combina el uso de GPS con una encuesta, al conocimiento de los patrones espaciales de los cruceristas que visitan la ciudad de Valencia de manera independiente. Los resultados obtenidos evidencian la polarización de los flujos en el centro histórico de la ciudad, dentro de un patrón mayoritario de único nodo, una dinámica que conviene gestionar adecuadamente para prevenir la congestión y poner en valor otros atractivos urbanos. La redistribu…
Nomenclatural notes on Fabaceae described from Sicily
2021
A note about some taxa in Anthyllis and Trifolium (Fabaceae) described from Sicily is presented. Concerning Trifolium, we provide the lectotypification of the name T. pratense var. semipurpureum (≡ T. pratense subsp. semipurpureum), using a specimen preserved at PAL (Todaro’s collection). Concerning the Lojacono-Pojero’s name Vulneraria heterophylla var. parvula, it is lectotypified by a specimen at G. A neotype at NAP is proposed for the Gussone’s name Vulneraria heterophylla var. albiflora. As this latter name is applied to a taxon accepted here at specific rank, a new combination is validated. On the contrary, A. heterophylla var. parvula is considered as a new heterotypic synonym of Ant…
The dnaK operon of Streptomyces coelicolor encodes a novel heat-shock protein which binds to the promoter region of the operon
1995
Transcriptional studies have demonstrated that the dnaK gene of Streptomyces coelicolor A3(2) is contained within a 4.3 kb operon. The operon is transcribed from a single (transiently) heat-inducible promoter, dnaKp, that resembles the typical vegetative (sigma 70-recognized) eubacterial consensus promoter sequence. dnaK transcription was found to be heat-inducible at all stages of development in surface-grown cultures. In addition, at the normal growth temperature of 30 degrees C, dnaK transcript levels were shown to vary at different stages of development, being more abundant in young germinating cultures and in mycelium undergoing sporogenesis. The nucleotide sequence of the dnaK operon …
Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signalling cascade mediated by the PDGFR-β
2009
Aims We have recently shown that urokinase plasminogen activator (uPA) increases oxidative stress (OS), cholesterol biosynthesis, and paraoxonase 2 (PON2) expression in macrophages via binding to its receptor, the uPAR. Since PON2 is regulated by both OS and cholesterol content, we hypothesized that uPA elicits a cascade of signal transduction events shared by NADPH oxidase and cholesterol biosynthesis that culminates in PON2 gene expression. Here, we investigated the signalling pathway that leads to the expression of PON2 in macrophages in response to uPA. Methods and results The increase in macrophage PON2 mRNA levels in response to uPA was shown to depend on PON2 gene promoter activation…
Regulation ofMUC1Expression in Human Mammary Cell Lines by the c-ErbB2 and Ras Signaling Pathways
2001
The MUC1 protein is a highly O-glycosylated transmembrane molecule that is expressed at the luminal surface of most glandular epithelial cells and is upregulated in carcinomas. Here, we report the effect of the activation of the c-ErbB2 --Ras pathway on the expression of the MUC1 gene in the nontumorigenic mammary cell lines MTSV1-7 and HB2 and in the malignant cell lines T47D and ZR75. Endogenous levels of MUC1 mRNA and protein in HB2 clones permanently overexpressing c-ErbB2 or V12-H-Ras were markedly reduced compared with levels in the parental cell lines. Furthermore, in transient transfection assays, the transcription of a CAT reporter construct driven by the MUC1 promoter was inhibite…
Regulation of the peroxisomal β-oxidation-dependent pathway by peroxisome proliferator-activated receptor α and kinases
2000
The first PPAR (peroxisome proliferator-activated receptor) was cloned in 1990 by Issemann and Green (Nature 347:645-650). This nuclear receptor was so named since it is activated by peroxisome proliferators including several drugs of the fibrate family, plasticizers, and herbicides. This receptor belongs to the steroid receptor superfamily. After activation by a specific ligand, it binds to a DNA response element, PPRE (peroxisome proliferator response element), which is a DR-1 direct repeat of the consensus sequence TGACCT x TGACCT. This mechanism leads to the transcriptional activation of target genes (Motojima et al., J Biol Chem 273:16710-16714, 1998). After the first discovery, severa…
El ingeniero Antonio Navarro-Reverter y Ortoll. La continuación de una saga familiar en la compañía de tranvías y ferrocarriles de Valencia
2007
El ingeniero Antonio Fernando José Navarro-Reverter y Ortolt encarna en su persona la voluntad de una familia que ejerció su profesión a lo largo de diferentes generaciones, teniendo entre sus principales objetivos la creación y evolución del ferrocarril valenciano. Este ingeniero trabajó veinticinco años para la Compañía de Tranvías y Ferrocarriles de Valencia, realizando proyectos de ampliación y mejora de sus infraestructuras. (A)
Efectos del ajo en ratones infectados experimentalmente con Echinostoma caproni
2017
Debido a la inexistencia de vacunas antihelmínticas, el control de las infecciones por helmintos intestinales depende fundamentalmente de las medidas higiénico-sanitarias y de la quimioterapia. Sin embargo, la continua aparición de resistencias a los tratamientos habituales hace necesario desarrollar nuevos fármacos contra estos parásitos. En este trabajo, se han investigado los potenciales efectos antihelmínticos del ajo (Allium sativum), a dosis dietéticas, sobre trematodos intestinales trasmitidos por alimentos, empleando para ello el modelo Echinostoma caproni-roedor. Los efectos potenciales del consumo del ajo en la prevención y/o tratamiento de la infección se analizaron siguiendo dif…
Multiple reaction monitoring for identification and quantification of oligosaccharides in legumes using a triple quadrupole mass spectrometer.
2022
Raffinose family oligosaccharides are non-digestible compounds considered as dietary prebiotics with health-related properties. Hence, it is important to develop highly specific methods for their determination. An analytical method is developed in this study for oligosaccharide identification and quantification using liquid chromatography-tandem mass spectrometry equipped with a triple quadrupole analyser operating in Multiple Reaction Monitoring mode. Raffinose, stachyose and verbascose are separated in a 10-minute run and the method is validated over a broad concentration range, showing good linearity, accuracy, precision and high sensitivity. A low-cost, short eco-friendly procedure for …