Search results for "ict"
showing 10 items of 7961 documents
Toxic Theisms? New Strategies for Prebunking Religious Belief-Behaviour Complexes
2020
This article offers a brief epidemiological analysis and description of some of the main cognitive (and coalitional) biases that can facilitate the emergence and enable the maintenance of a broad category of toxic traditions, which will be referred to here as “religious” belief-behaviour complexes (BBCs) or “theisms”. I argue that such BBCs played an “adaptive” role in the Upper Paleolithic and have continued to “work” throughout most of human history by enhancing the species’ capacity for material production and promoting its biological reproduction. However, today the theist credulity and conformity biases that surreptitiously shape these kinds of social assemblages have now becom…
DALLA PUNIZIONE ALLA RIPARAZIONE? ASPIRAZIONI E LIMITI DELL’ENNESIMA RIFORMA ANTICORRUZIONE (LEGGE N. 69/2015)
2015
Il testo propone un commento critico delle norme anticorruzione contenute nella l. 69/2015. La tesi di fondo è che la dichiarata aspirazione a privilegiare una strategia riparatoria è in realtà smentita dal contenuto effettivo di molte delle norme introdotte, le quali mantengono invece un tenore saldamente punitivo.
TAP off - tumors on
1997
Abstract The molecular characterization of T-cell-defined tumor-associated antigens has provided targets for cell-mediated immunotherapy for malignant diseases. The success of this strategy is negatively influenced by structural and functional abnormalities of major histocompatibility complex (MHC) class I molecules, which provide tumor cells with resistance to T-cell-mediated immune recognition. This article reviews the physiology of the MHC class I processing machinery and describes the deficiencies of this pathway in malignant cells.
The enemy in you: the interdependency of the localisation and antigenicity of proteins
2009
The subcellular localisation of protein components should be important for their antigenicity. This assumption is derived from the concept of MHC restriction, where CD4 and CD8 T lymphocytes can only interact with MHC II and MHC I surface receptors, respectively. If this mechanism applies, however, then intracellular components should have immunogenic effects mediated by MHC II and CD4 T lymphocytes as soon as they enter the extracellular space. Conversely, extracellular components should generate an immune response that is mediated by MHC I and CD8 lymphocytes when they breach the intracellular space and when they exceed a critical concentration. In this study, these hypotheses were invest…
Stimulation of human T cells by microbial 'superantigens'.
1991
The enterotoxins and the TSST of S. aureus, the erythrogenic toxins A and C of S. pyogenes and a still uncharacterized exoprotein of M. arthritidis belong to a family of exotoxins that have in common a potent mitogenic activity for T lymphocytes of several species. These proteins stimulate CD4+ and C8+ T cells, as well as a fraction of gamma delta TCR-bearing T cells by cross-linking variable parts of the T cell antigen receptor with MHC class II molecules on accessory or target cells. They are functionally bivalent molecules having distinct interaction sites for variable parts of the TCR and for nonpolymorphic parts of the MHC class II molecule. For alpha beta TCR-bearing T cells the V bet…
Determination of antimony in drinking waters by an inexpensive, reproducible hydride generator for atomic spectroscopy.
1991
A method for determining antimony in drinking waters is described. In order to prevent a substantial error caused by the different oxidation states of antimony, Sb(V) is reduced to Sb(III) with potassium iodide-ascorbic acid. Covalent hydride is generated with a home made device by adding NaBH4. The hydride is then atomized in a flame-heated silica tube and atomic absorption is measured spectrophotometrically. The optimal conditions for this determination are discussed and interference effects are described. Results obtained by determining linearity range (0-200 ng), detection (LOD) and quantitation (LOQ) limits (LOD = 0.347 ng/ml, LOQ = 1.158 ng/ml), precision (instrumental CV 4.08% and me…
Theoretical Determination of the pK a Values of Betalamic Acid Related to the Free Radical Scavenger Capacity: Comparison Between Empirical and Quant…
2015
Health benefits of dietary phytochemicals have been suggested in recent years. Among 1000s of different compounds, Betalains, which occur in vegetables of the Cariophyllalae order (cactus pear fruits and red beet), have been considered because of reducing power and potential to affect redox-modulated cellular processes. The antioxidant power of Betalains is strictly due to the dissociation rate of the acid moieties present in all the molecules of this family of phytochemicals. Experimentally, only the pK a values of betanin were determined. Recently, it was evidenced it was evidenced as the acid dissociation, at different environmental pHs, affects on its electron-donating capacity, and fur…
Variaciones del drama historial en Lope de Vega
2013
A partir de la exposición de los fundamentos que subyacen a la investigación presentada, y que la vinculan a otras anteriores, y en los que se aborda el concepto y las características del drama historial en Lope de Vega, el ensayo se centra en la distinción de dos modos fundamentales del drama historial: la conmemoración de hechos históricos famosos, por un lado, y el análisis del conflicto moral, casi siempre de índole privada, que estalla en circunstancias históricas concretas, por el otro. Estas dos grandes estrategias de significación, la propia de la construcción de una memoria colectiva, asociada a la de la identidad de la naciente nación, y la propia de la exploración de la identidad…
El proyecto mapa escolar de Valencia: Análisis de la zonificación educativa de la ciudad de Valencia
2018
The research project Mapa Escolar de Valencia (School Map of Valencia) was born out of an agreement between the City Council and the University of Valencia in order to carry out an investigation of the compulsory education system of the city and propose, if necessary, modifications to the current school zoning. The project is structured in several research areas. An analysis of the specialized scientific literature and public policies concerning education and schooling has been done, and it is currently analysing the evolution of quantitative and qualitative data on compulsory schooling in Valencia, its school zoning, the representations of education and the school climate in the city schoo…
Cambios de usos del suelo y régimen hídrico en la rambla de Poyo y el barranc de Carraixet
2002
421 pages; http://www.tesisenxarxa.net/TDX-0218104-092141/index_cs.html#documents