Search results for "import"

showing 10 items of 286 documents

Translocation Biosensors – Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics

2009

Fluorescent protein biosensors are powerful cellular systems biology tools for dissecting the complexity of cellular processes with high spatial and temporal resolution. As regulated nucleo-cytoplasmic transport is crucial for the modulation of numerous (patho)physiological cellular responses, a detailed understanding of its molecular mechanism would open up novel options for a rational manipulation of the cell. In contrast to genetic approaches, we here established and employed high-content cellular translocation biosensors applicable for dissecting nuclear export by chemicogenomics. A431 cell lines, stably expressing a translocation biosensor composed of glutathione S-transferase, GFP and…

Systems biologyChemical biologyNanotechnologychemical biologyComputational biologyBiologylcsh:Chemical technologyBiochemistryArticleAnalytical ChemistryGreen fluorescent proteinFlow cytometrychemical biology; cancer; Exportin 1/CRM1; HIV-1 Rev; import; LMB; nucleocytoplasmic transport; nucleoporinimportmedicinecancerlcsh:TP1-1185Electrical and Electronic EngineeringNuclear export signalLMBInstrumentationExportin 1/CRM1HIV-1 Revnucleocytoplasmic transportmedicine.diagnostic_testnucleoporinAtomic and Molecular Physics and OpticsChemical spacecancer ; HIV-1 Rev ; import ; nucleocytoplasmic transport ; LMB ; chemical biology ; Exportin 1/CRM1 ; nucleoporinNucleoporinNuclear transportBiologieSensors
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Response to Skeide and Friederici: The myth of the uniquely human “direct” dorsal pathway

2015

In their comment on our recent article [1], Skeide and Friederici [2] claim ‘that some important data not discussed by Bornkessel-Schlesewsky et al. strongly support the view that there are clear qualitative, and not merely quantitative, differences between [human and nonhuman primate] species with respect to both the intrinsic functional connectivity of frontal and temporal cortices, and their direct structural connection via a dorsal white matter fiber tract.’ This obviously refers to work by Friederici and colleagues [3] emphasizing the functional importance of a direct connection between the posterior superior temporal cortex (pSTC) and Brodmann area (BA) 44 in humans, and its absence i…

Temporal cortexDorsumPrimatesCognitive NeuroscienceFunctional connectivityletterBrainExperimental and Cognitive PsychologyNonhuman primateArticleNeuropsychology and Physiological PsychologyFunctional importanceAuditory PerceptionAnimalsHumansPsychologyNeuroscienceTemporal CorticesBrodmann areaLanguage
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Event generation and statistical sampling for physics with deep generative models and a density information buffer

2021

Simulating nature and in particular processes in particle physics require expensive computations and sometimes would take much longer than scientists can afford. Here, we explore ways to a solution for this problem by investigating recent advances in generative modeling and present a study for the generation of events from a physical process with deep generative models. The simulation of physical processes requires not only the production of physical events, but to also ensure that these events occur with the correct frequencies. We investigate the feasibility of learning the event generation and the frequency of occurrence with several generative machine learning models to produce events l…

Test data generationScienceMonte Carlo methodGeneral Physics and AstronomyFOS: Physical sciences01 natural sciencesCharacterization and analytical techniquesGeneral Biochemistry Genetics and Molecular BiologyArticleHigh Energy Physics - ExperimentHigh Energy Physics - Experiment (hep-ex)High Energy Physics - Phenomenology (hep-ph)0103 physical sciencesInformation theory and computationHigh Energy Physics010306 general physicsMultidisciplinary010308 nuclear & particles physicsEvent (computing)QStatisticsData ScienceSampling (statistics)General ChemistryDensity estimationAutoencoderHigh Energy Physics - PhenomenologyPhysics - Data Analysis Statistics and ProbabilityExperimental High Energy PhysicsAnomaly detectionAlgorithmImportance samplingData Analysis Statistics and Probability (physics.data-an)
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La scoperta, sistemazione e conservazione della grande Iscrizione di Gortina, nell'isola di Creta (1884-1921): la protezione delle testimonianze e le…

2013

La scoperta e la conservazione della Grande Iscrizione di Gortina a Creta, da parte degli studiosi italiani, fra la fine del XIX sec. e i primi decenni del XX sec., rappresentò un grande riconoscimento scientifico-culturale per la giovane nazione italiana. Nel passato, l’isola di Creta era stata legata alla Repubblica di Venezia e anche questo rapporto favorì l’invio a Creta del giovane epigrafista F. Halbherr, il quale fra notevoli peripezie rinvenne, assieme all’epigrafista tedesco E. Fabricius, la famosa l’iscrizione nell’antica città di Gortina. L’iscrizione, fra le più antiche e complete finora conosciute in tutta Europa, conteneva le norme sulla famiglia, l’eredità e in generale i dir…

The discovery and preservation of the Great Inscription of Gortyna in Crete by Italian researchers in the late nineteenth century. and the first decades of the twentieth century. was an important cultural and scientific recognition for the young Italian nation. In the past the island of Crete had been tied to the Republic of Venice and this report also favored sending in Crete the young epigraphist F. Halbherr who among considerable vicissitudes came to together to the epigraphist german E. Fabricius the inclusion of the famous ancient city of Gortyna. The inscription among the oldest and most comprehensive so far known throughout Europe the rules contained on the family's legacy in general and the rights and duties of some of the people of the Minoan civilization (480-450 BC). The inscription was carved on blocks organic limestone a restored ancient building which later in Roman times was turned into odeon. The Laws of Gortyn were engraved on the remains of the wall forming the passageway in front of the steps of the odeon. The essay traces the events that led to the discovery and subsequent storage made by Halbherr especially with the help of archaeologist L. Pernier and finally with the help of architect E. Stefani who designed a modern cover on the top of the ambulatory of the segments containing the inscription. This coverage was made to perform during the First World War on the basis of the Italian project from the Greek Government in order to protect the membership from possible war damage but especially from vandalism. The roof brick clay of the Laws of Gortyna still serves its function and ensures the use of the monument bearing witness to the preservation of Italian culture in Greece and more generally in the world. But in Sicily in the remains of the Villa del Casale in Piazza Armerina (Enna) its elegant protection (built in 1957) is representative of a whole period of culture of the Italian restoration is removed and replaced because it has not been able to make a ongoing maintenance is due. A bad example of conservation and management of a UNESCO monument from which arise after the work for the construction of new roofs an equally insulting to the archaeological heritage and scenic Italian and world.Settore ICAR/19 - Restauro
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Tutela e sicurezza del lavoro tra centro e periferia: la sicurezza sui luoghi di lavoro

2013

Il saggio prende in esame la complessa questione del riparto di competenze tra Stato e Regioni alla luce del Titolo V della Costituzione in materia di salute e sicurezza sui luoghi di lavoro. Il riparto di competenze tra centro e periferia è stato oggetto di una limitata analisi da parte della dottrina e della giurisprudenza, che si sono concentrate in particolare sulla disciplina del mercato del lavoro. L’Autore descrive un sistema multilivello, caratterizzato dalla compresenza di fonti nazionali e regionali, della contrattazione collettiva, nonché di codici di condotta. Sulla scorta di una ricostruzione del quadro normativo e dei percorsi della giurisprudenza, il saggio propone una lettur…

The essay examines the complex issue of the division of powers between the State and the Regions according to Title V of the Constitution concerning health and safety at workplace. This division between the center and the periphery has been subject to a limited review by doctrine and jurisprudence expecially focusing on the regulation of labour market. The Author describes a multilevel system characterized by the presence of national and regional sources collective bargaining and codes of conduct. On the basis of a reconstruction of the regulatory framework and the judicial statements the paper proposes a dynamic reading of the relationship between center and periphery in which the axis of the system remains however anchored to the national jurisdiction along with important regulatory issues left to the regional legislation.Settore IUS/07 - Diritto Del Lavoro
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I feudi a masserie nell'arcivescovato di Monreale. Un esempio di organizzazione economica del territorio (secc. XV-XVII)

2022

Il saggio indaga "i feudi a masserie", uno dei segmenti economici e giuridici più importanti del territorio dell'arcivescovato di Monreale.

The essay investigates "the fiefdoms and farms" one of the most important economic and legal segments of the territory of the archbishopric of Monreale.Settore M-STO/02 - Storia Moderna
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L'ecomuseo del grano e del pane: un percorso progettuale centrato sul design

2018

La festa di S. Giuseppe, oltre che un’importante e sentita ricorrenza religiosa, è a Salemi soprattutto la “festa dei pani”; bellissime realizzazioni di alto artigianato artistico, la cui sapienza si tramanda nelle famiglie e nelle associazioni di donne che per mesi lavorano alla produzione dell’enorme quantità delle piccole e grandi forme di pane, per rivestire le costruzioni votive che accolgono il rito della cena. Nasce quindi l’idea di proporre un “Ecomuseo del grano e del pane” nel Collegio dei Gesuiti, valorizzando e riaprendo al pubblico uno spazio di grande interesse storico-architettonico. Nell’ambito della consolidata collaborazione del Comune di Salemi con il Dipartimento di Arch…

The feast of St. Joseph as well as an important and heartfelt religious celebration is in Salemi above all the "feast of the loaves"beautiful achievements of high artistic craftsmanship whose wisdom is handed down in the families and in the associations of women who for many months work to produce the enormous quantity of small and large forms of bread to cover the votive constructions that welcome the ritual of dinner.Thus the idea of proposing an "Ecomuseum of wheat and bread" in the Jesuit College was born enhancing and re-opening a space of great historical-architectural interest to the public. As part of the consolidated collaboration of the Municipality of Salemi with the Department of Architecture professors and students worked on a strategic design project for museum set-up and communication also open forms of participation and sharing with the various territorial actors in a sort of 'social conversation' with the protagonists and skills in the field. A collaboration with Polimi Desis_Lab of the Milan Polytechnic concerning the contribution of the 'design of services for social innovation' was also initiated on these aspects.Settore ICAR/13 - Disegno Industriale
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DECORIN EFFECTS ON PROTEOMIC PROFILING OF BREAST CANCER CELLS: AN UPDATED STUDY

2015

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells, among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect, the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules, the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin, belongs to the family of small leucine-rich proteoglycans (SLRP) and is involv…

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin belongs to the family of small leucine-rich proteoglycans (SLRP) and is involved physiologically in the fibrillogenesis of collagen. In the last few year a new anti-oncogenic role has been proposed for decorin1. This study aimed to implement the knowledge on the effects of ectopic decorin on breast cancer cells using as a reference point the results already achieved by our research group2 on the experimental model format. By breast cancer cell line 8701-BC and its transfected clone DEC-C2. The extension of the proteomic analysis combined with the mass spectrometry allowed to triplicate the number of identified proteins in our model. Among the newly identified proteins were members of the classes of metabolic enzymes S100 family and cell motility proteins which revealed a net decrease in the decorin transfected cells. Of considerable importance is the observation that these classes of proteins are the most involved in metastatic progression. These results confirm and reinforce the anti-oncogenic role hypothesized for decorin. The work was co-funded by the Italian 5x1000 to COBS.DECORIN
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Una nuova acquisizione iconografica per la ricostruzione della tribuna di Antonello Gagini nella Cattedrale di Palermo

2022

La recente digitalizzazione di un dipinto di anonimo siciliano nelle collezioni del Museo de Historia di Madrid e il suo inserimento nei database del patrimonio culturale spagnolo ed europeo ha consentito di riportare all’attenzione della comunità scientifica un’importante raffigurazione pittorica della tribuna di Antonello Gagini nella Cattedrale di Palermo. Dopo avere ripercorso le principali fonti documentarie ed iconografiche relative alla tribuna, viene qui presentata l’opera oggi a Madrid, che fornisce un prezioso riscontro alle fonti fin qui note.

The recent digitisation of a painting by an anonymous Sicilian in the collections of the Museo de Historia in Madrid and its inclusion in the Spanish and European cultural heritage databases has made it possible to bring an important pictorial representation of Antonello Gagini’s tribune in Palermo Cathedral back to the attention of the scientific community. After reviewing the main documentary and iconographic sources relating to the tribune the work now in Madrid is presented here which provides a valuable comparison to the sources known so far.
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Epistemic and didactic values of the demonstrative process in different cultures: a case study in Geometry with Chinese and Italian students

2011

This paper presents same key findings of the research project conducted by G.R.I.M. of Palermo on the approaches to justification and proof in Geometry by investigating how Chinese and Italian teachers and students taught particular geometrical topics refereed to different epistemic and didactic values related to own culture. It was found that Chinese teachers and students emphasized justification of the proof by a stressed visual verification based on some metarules linked with the structure of their own written language and defined as historical Chinese modus operandi in the Jiuzhang Suanshu. The Italians paid close attention to mathematical proof by a hypoxemic deductive system defined on the Euclide’ Elements. The geometrical problem discussed on the paper was defined and presented as “one problem multiple solution problems” and “one problem multiple changes”. Important aspect of the case study discussed in the paper focus on the mediation of knowledge between Chinese and Italian students involved in multicultural class. According to us these kind of activities can establish possibilities for the students to confront their self with different cultural social and educational prospective of knowledge discovering the power of mathematics as tool of negotiation in multicultural class?Settore MAT/04 - Matematiche Complementari
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