Search results for "init"

Highly Loaded Semipermeable Nanocapsules for Magnetic Resonance Imaging.

2017

Magnetic resonance imaging has become an essential tool in medicine for the investigation of physiological processes. The key issues related to contrast agents, i.e., substances that are injected in the body for imaging, are the efficient enhancement of contrast, their low toxicity, and their defined biodistribution. Polyurea nanocapsules containing the gadolinium complex Gadobutrol as a contrast agent in high local concentration and high relaxivity up to 40 s-1 mmol-1 L are described. A high concentration of the contrast agent inside the nanocapsules can be ensured by increasing the crystallinity in the shell of the nanocapsules. Nanocapsules from aliphatic polyurea are found to display hi…

Global variability in seawater Mg:Ca and Sr:Ca ratios in the modern ocean

2020

12 pages, 5 figures, supporting information https://doi.org/10.1073/pnas.1918943117.-- Data Availability. Our published databases are publicly accessible for readers, and they are deposited at the NOAA NCEI at https://data.nodc.noaa.gov/cgi-bin/iso?id=gov.noaa.nodc:0171017.-- Correction for Lebrato et al., Global variability in seawater Mg:Ca and Sr:Ca ratios in the modern ocean; Proceedings of the National Academy of Sciences of the USA 118(49): e2119099118 (2021); doi: 10.1073/pnas.2119099118; http://hdl.handle.net/10261/258054.-- This is Pacific Marine Environmental Laboratory contribution number 5046

Electronic aspects of the hydride transfer mechanism. Ab initio analytical gradient studies of the cyclopropenyl‐cation/lithium hydride model reactan…

1985

The electronic mechanisms of a model hydride transfer reaction are theoretically studied with ab inito RHF and UHF SCF MO procedures at the 4‐31G basis set level and analytical gradient methods. The model system describes the reduction of cyclopropenyl cation to cyclopropene by the oxidation of lithium hydride to lithium cation. The molecular fragments corresponding to the asymptotic reactive channels characterizing the stepwise mechanisms currently discussed in the literature have been characterized. The binding energy between the fragments is estimated within a simple electrostatic approximate scheme. The results show that a hydride‐ion mechanism is a likely pathway for this particular sy…

Effects of hydrostatic pressure on the thermoelectric properties of the ϵ-polytype of InSe, GaSe, and InGaSe2 semiconductor compounds: anab initiostu…

2017

An ab initio potential energy surface for the C2H2-N2 system

2012

International audience; An ab initio potential energy surface determined at the CCSD(T) level of theory is presented for the van der Waals complex C2H2-N2. Additional calculations performed with the HF- and DFT-SAPT methods compare well with the CCSD(T) results and allow a better understanding of the main features of this interaction potential surface. An expansion of this surface over spherical harmonics has also been performed. The global energy minimum of the complex is obtained for the linear conformation. The T conformations are the least attractive. Such characteristics mainly arise because of the variation, in sign and in absolute value of the electrostatic energy between all these c…

Performance of polyester-based electrospun scaffolds under in vitro hydrolytic conditions: From short-term to long-term applications

2019

The evaluation of the performance of polyesters under in vitro physiologic conditions is essential to design scaffolds with an adequate lifespan for a given application. In this line, the degradation-durability patterns of poly(lactide-co-glycolide) (PLGA), polydioxanone (PDO), polycaprolactone (PCL) and polyhydroxybutyrate (PHB) scaffolds were monitored and compared giving, as a result, a basis for the specific design of scaffolds from short-term to long-term applications. For this purpose, they were immersed in ultra-pure water and phosphate buffer solution (PBS) at 37 &deg

Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy

2013

Vici syndrome is a recessively inherited multisystem disorder characterized by callosal agenesis, cataracts, cardiomyopathy, combined immunodeficiency and hypopigmentation. To investigate the molecular basis of Vici syndrome, we carried out exome and Sanger sequence analysis in a cohort of 18 affected individuals. We identified recessive mutations in EPG5 (previously KIAA1632), indicating a causative role in Vici syndrome. EPG5 is the human homolog of the metazoan-specific autophagy gene epg-5, encoding a key autophagy regulator (ectopic P-granules autophagy protein 5) implicated in the formation of autolysosomes. Further studies showed a severe block in autophagosomal clearance in muscle a…

ROLES DE GÉNERO Y AGRESIVIDAD EN LA ADOLESCENCIA

2016

Abstract:GENDER ROLES AND AGGRESSIVENESS IN ADOLESCENCEAdolescent and Young violence remains a concern which damages their biopsychosocial development and involves several factors. The binomial sex-gender has revealed considerable influence on aggressive behavior among adolescents. In order to study in depth our knowledge about these variables, this study analyzes the relation between gender category (masculinity, feminity, adrogyny or undifferentiated) and sex (men or women) to adolescent aggressiveness. For this purpose, by the Spanish adaptation of Sexual Role Inventory by Bem (García-Mina Freire, 2004) and the Cuestionario de Información, Actitudes y Comportamientos relacionados con la …

Production and characterisation of recombinant forms of human pulmonary surfactant protein C (SP-C):Structure and surface activity

2006

  Udgivelsesdato: 2006-Apr Surfactant protein C (SP-C) is an essential component for the surface tension-lowering activity of the pulmonary surfactant system. It contains a valine-rich alpha helix that spans the lipid bilayer, and is one of the most hydrophobic proteins known so far. SP-C is also an essential component of various surfactant preparations of animal origin currently used to treat neonatal respiratory distress syndrome (NRDS) in preterm infants. The limited supply of this material and the risk of transmission of infectious agents and immunological reactions have prompted the development of synthetic SP-C-derived peptides or recombinant humanized SP-C for inclusion in new prepar…

Photoimaging through in-Situ Photopolymerization of Heterobifunctional Mesogenic Compounds in Liquid Crystalline State

2007

A series of heterobifunctional mesogenic biphenyl esters having two different polymerizable groups, i.e., acryl and diacetylene groups, were synthesized and their thermal behaviors and polymerization investigated. All compounds showed enantiotropic transitions. Under POM, highly birefringent focal-conic fan textures appeared on heating and cooling from the isotropic melt. Compounds 6−8 having a butyl spacer between a biphenyl and a diacetylene group exhibited LC phases even at room temperature. The X-ray diffractograms of compounds 6−8 showed a set of reflections in the small-angle region. They consisted of more than three sharp diffraction peaks with d spacings in the ratio of 1:1/2:1/3, s…