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showing 10 items of 384 documents
Immunoelectron microscopic localization of nitric oxide synthase III in the guinea pig organ of Corti
1998
Nitric oxide synthase III (NOS III) was identified in the guinea pig cochlea on an ultrastructural level using a post-embedding immunolabeling procedure. Ultrathin sections of London Resin (LR) White-embedded specimens were incubated with various concentrations of a commercially available antibody to NOS III and the immunoreactivity visualized by a gold-labeled secondary antibody. Analysis of ultrathin sections of the organ of Corti in the second turn of the cochlea showed that NOS III could be localized in the endothelial cells of the blood vessels under the basilar membrane, which was comparable to its location in similar cells types in various biological systems. Besides this, NOS III wa…
Subtle retinal pathology in amyotrophic lateral sclerosis
2014
Amyotrophic lateral sclerosis (ALS) is characterized by neuro-ophthalmological abnormalities beyond disturbed oculomotor control such as decreased visual acuity and disturbed visual evoked potentials. Here we report retinal alterations in a cohort of 24 patients with clinically definite (n = 20) or probable (n = 4) ALS as compared to matched controls. High-resolution spectral domain optical coherence tomography with retinal segmentation revealed a subtle reduction in the macular thickness and the retinal nerve fiber layer (RNFL) as well as a marked thinning of the inner nuclear layer (INL). Our data indicate an unprecedented retinal damage pattern and suggest neurodegeneration beyond the mo…
Role of mitochondria in parvovirus pathology.
2014
Proper functioning of the mitochondria is crucial for the survival of the cell. Viruses are able to interfere with mitochondrial functions as they infect the host cell. Parvoviruses are known to induce apoptosis in infected cells, but the role of the mitochondria in parvovirus induced cytopathy is only partially known. Here we demonstrate with confocal and electron microscopy that canine parvovirus (CPV) associated with the mitochondrial outer membrane from the onset of infection. During viral entry a transient depolarization of the mitochondrial transmembrane potential and increase in ROS level was detected. Subsequently, mitochondrial homeostasis was normalized shortly, as detected by rep…
A network of superconducting gravimeters as a detector of matter with feeble nongravitational coupling
2020
Abstract Hidden matter that interacts only gravitationally would oscillate at characteristic frequencies when trapped inside of Earth. For small oscillations near the center of the Earth, these frequencies are around 300 μHz. Additionally, signatures at higher harmonics would appear because of the non-uniformity of Earth’s density. In this work, we use data from a global network of gravimeters of the International Geodynamics and Earth Tide Service (IGETS) to look for these hypothetical trapped objects. We find no evidence for such objects with masses on the order of 1014 kg or greater with an oscillation amplitude of 0.1 re. It may be possible to improve the sensitivity of the search by s…
New ALICE detectors for Run 3 and 4 at the CERN LHC
2020
Abstract Run 3 at the CERN LHC is scheduled to start in March 2021. In preparation for this new data taking period the ALICE experiment is making major modifications to its subsystems and is introducing three new detectors: the new Inner Tracking System, the Muon Forward Tracker, and the Fast Interaction Trigger. The new detectors will enhance tracking, especially at low transverse momenta, improve vertexing, provide the required triggering, fast timing, luminosity, and forward multiplicity functionality. For instance, it will be possible to measure beauty from displaced J/ ψ vertices down to transverse momenta p T ∼ 0 and improve precision for the ψ (2S) measurements. The upgraded ALICE wi…
Lärm als Umweltproblem
1976
Noise as an Environmental Problem. Anatomical structure and physiological function of the human ear are described. It is shown that constant noise stress leads to damage of certain parts of the inner ear. These damages proceed characteristically and may be diagnosed relatively early by means of audiometric tests. VDI-instructions 2058 (sheet 2) prescribes screening-tests for an earliest possible detection of incipient noise damage. In addition to ear-damaging effects of noise there have also been recorded physiological reactions under noise influence. Such disturbances, however, cannot as yet be described as an “Extraaural disease”. On the other hand, the fact that high sound intensities of…
Shifting Imageries: Gentrification and the New Touristic Images of the Inner City of Palermo
2021
After the bombings of 1943, the historic centre of Palermo was left with several crumbling buildings and a social situation of some concern. Therefore, over the last sixty years, all kinds of representations of Palermo have revolved around the presence of criminal organizations and the risks of living in the most dangerous areas of the city (including the city centre). These representations started to change around the beginning of the new century when the inner city of Palermo underwent an intense process of redefinition of its territorial identity. Several key factors may be used to explain this process: from traditional economic reasons concerning gentrification and touristification, to …
Differences in inner ear asymmetry levels between slow-moving and fast-moving primates
2021
International audience; The vestibular system of the inner ear, highly involved in maintaining balance during activities and positional behaviour of animals, has been deeply studied in order to link its morphology with the specific type of locomotion. Previous studies (e.g. Perier et al. 2016, Gonzales et al. 2018) have shown that, in primates, the amount of morphological variation is higher in slow-moving species than in fast-moving ones. These results indicate a lower selective pressure and a reduced functional demand for postural adjustments in the former group, and a higher selective pressure for balance and postural capabilities in the latter. In this study, we assessed if the differen…
Dexamethasone treatment of naïve organ of Corti explants alters the expression pattern of apoptosis-related genes.
2009
Dexamethasone treatment of organ of Corti explants challenged with an ototoxic level of an inflammatory cytokine modulates NFkappaB signaling and the expression levels of both pro-and anti-apoptosis-related genes. It is not known if naïve organ of Corti explants will respond in a similar manner to treatment with a corticosteroid. This study examines the response of naïve organ of Corti explants to treatment with dexamethasone.Three-day-old rat organ of Corti explants were cultured for 1, 2, or 4 days. Four-day in vitro cultures were fixed, stained with FITC-phalloidin and hair cells were counted. ELISA was performed on 2-day cultures to determine the levels of phosphorylated nuclear factor …
Transmembrane BAX Inhibitor-1 Motif Containing Protein 5 (TMBIM5) Sustains Mitochondrial Structure, Shape, and Function by Impacting the Mitochondria…
2020
The Transmembrane Bax Inhibitor-1 motif (TMBIM)-containing protein family is evolutionarily conserved and has been implicated in cell death susceptibility. The only member with a mitochondrial localization is TMBIM5 (also known as GHITM or MICS1), which affects cristae organization and associates with the Parkinson&rsquo