Search results for "inner"

Stage-specific germ-cell marker genes are expressed in all mouse pluripotent cell types and emerge early during induced pluripotency.

2011

Embryonic stem cells (ESCs) generated from the in-vitro culture of blastocyst stage embryos are known as equivalent to blastocyst inner cell mass (ICM) in-vivo. Though several reports have shown the expression of germ cell/pre-meiotic (GC/PrM) markers in ESCs, their functional relevance for the pluripotency and germ line commitment are largely unknown. In the present study, we used mouse as a model system and systematically analyzed the RNA and protein expression of GC/PrM markers in ESCs and found them to be comparable to the expression of cultured pluripotent cells originated from the germ line. Further, siRNA knockdown experiments have demonstrated the parallel maintenance and independen…

Fixpunktmengen von halbeinfachen Automorphismen in halbeinfachen Lie-Algebren

1976

Let g be a semisimple Lie algebra over an algebraically closed field of characteristic 0. The set of fixed points of a semisimple inner automorphism of g is a regular reductive subalgebra of maximal rank [1], so it is defined by a subsystem of the root system Φ of g relative to a suitable Cartan subalgebra. The main theorem of the article characterizes the corresponding subsystems of Φ. The second part of the article shows how to compute the fixed point algebras of semisimple outer automorphisms of g. A complete list of all fixed point algebras is then easily obtainable. The results are applied to bounded symmetric domains. References

On product of p-sequential spaces

2016

Abstract The product of finitely many regular p-compact p-sequential spaces is p-compact p-sequential for any free ultrafilter p as it follows from [5] . In the paper is produced an example of a Hausdorff p-compact p-sequential space whose square is not p-sequential. It is also given an example of a space which is sP-radial, wP-radial, vwP-radial for any P ⊂ μ ( τ ) but its square is neither sP-radial nor wP-radial nor vwP-radial space.

The Drosophila Hox gene Ultrabithorax acts both in muscles and motoneurons to orchestrate formation of specific neuromuscular connections

2016

Hox genes are known to specify motoneuron pools in the developing vertebrate spinal cord and to control motoneuronal targeting in several species. However, the mechanisms controlling axial diversification of muscle innervation patterns are still largely unknown. We present data showing that the Drosophila Hox gene Ultrabithorax (Ubx) acts in the late embryo to establish target specificity of ventrally projecting RP motoneurons. In abdominal segments A2 to A7, RP motoneurons innervate the ventrolateral muscles VL1-4, with VL1 and VL2 being innervated in a Wnt4-dependent manner. In Ubx mutants, these motoneurons fail to make correct contacts with muscle VL1, a phenotype partially resembling t…

Influence of steel reinforcements on the behavior of compressed high strength R.C. circular columns

2012

Abstract In the present paper the focus is on the compressive response of short high strength reinforced concrete members having circular transverse cross-sections and reinforced with longitudinal steel bars and transverse spirals or hoops. An analytical model is proposed which allows one to estimate the confinement pressures exerted by transverse steel and by longitudinal bars during the loading process, taking into account the interaction of the hoops or spirals with the inner core both in the plane of the transverse steel and in the space between two successive hoops. Yielding of steel spirals or hoops and longitudinal bars including buckling phenomena and damage to the concrete core are…

Biomolecular conjugation inside synthetic polymer nanopores via glycoprotein-lectin interactions

2011

We demonstrate the supramolecular bioconjugation of concanavalin A (Con A) protein with glycoenzyme horseradish peroxidase (HRP) inside single nanopores, fabricated in heavy ion tracked polymer membranes. Firstly, the HRP-enzyme was covalently immobilized on the inner wall of the pores using carbodiimide coupling chemistry. The immobilized HRP-enzyme molecules bear sugar (mannose) groups available for the binding of Con A protein. Secondly, the bioconjugation of Con A on the pore wall was achieved through its biospecific interactions with the mannose residues of the HRP enzyme. The immobilization of biomolecules inside the nanopore leads to the reduction of the available area for ionic tran…

Analysis of the Ush2a Gene in Medaka Fish (Oryzias latipes)

2013

Patients suffering from Usher syndrome (USH) exhibit sensorineural hearing loss, retinitis pigmentosa (RP) and, in some cases, vestibular dysfunction. USH is the most common genetic disorder affecting hearing and vision and is included in a group of hereditary pathologies associated with defects in ciliary function known as ciliopathies. This syndrome is clinically classified into three types: USH1, USH2 and USH3. USH2 accounts for well over one-half of all Usher cases and mutations in the USH2A gene are responsible for the majority of USH2 cases, but also for atypical Usher syndrome and recessive non-syndromic RP. Because medaka fish (Oryzias latypes) is an attractive model organism for ge…

The Smart Land Paradigm in the Sicani Territorial Archipelago

2017

With the aim to identify the specific identities of the Sicani territory, to interpret them in a perspective of innovative development and to define strategies capable of intercepting programming in progress, it has been deepened the “territorial archipelago” theoretical framework , recognizing it into the Sicani territory and trying to use it as the base of a possible development of a Smart Land, as a “non-gravitational” paradigm able to recognize and to direct the new relations of the rur-urban local systems.

The adverse redox biochemistry of intramembrane thiols accounts for the lifespan-dependent cysteine depletion in the inner mitochondrial membrane of …

2013

The Ptolemy and Zbăganu constants of normed spaces

2010

Abstract In every inner product space H the Ptolemy inequality holds: the product of the diagonals of a quadrilateral is less than or equal to the sum of the products of the opposite sides. In other words, ‖ x − y ‖ ‖ z − w ‖ ≤ ‖ x − z ‖ ‖ y − w ‖ + ‖ z − y ‖ ‖ x − w ‖ for any points w , x , y , z in H . It is known that for each normed space ( X , ‖ ⋅ ‖ ) , there exists a constant C such that for any w , x , y , z ∈ X , we have ‖ x − y ‖ ‖ z − w ‖ ≤ C ( ‖ x − z ‖ ‖ y − w ‖ + ‖ z − y ‖ ‖ x − w ‖ ) . The smallest such C is called the Ptolemy constant of X and is denoted by C P ( X ) . We study the relationships between this constant and the geometry of the space X , and hence with metric fix…