Search results for "insert"

Parcours de formation des diplômés universitaires et insertion professionnelle : le cas des diplômés scientifiques

2008

08039

L'insertion professionnelle : plus de chômage, moins d'emploi pour les filles

1988

Bourgogne : l'entrée des filles dans la vie active

1986

Organismes de formation et alternance

1984

Jean-Jacques Paul, Die Ausbildungsstatten und der Ablauf der wiederholten Folgeausbildung : einige Beobachtungen nach dem ersten Jahr der in Kraft getretenen Massnahmen zur Qualifizierung der 16-18 jährigen (« Dispositif 16-18 »). Die mit der wiederholten Folgeausbildung gebundenen Einsätze sind vielfältig ; sie beziehen sich sowohl auf ihre pädagogischen Potentialitäten als auch auf das Risiko, die Einführung einer neuen von jungen Lehrgangbesuchern gebildeten Beschäftigtengruppe zu fördern. Diese Problematik wird hier durch die Analyse des ersten Ausbildungsjahres seit dem Inkrafttreten der Massnahmen zur Qualifizierung und beruflichen Eingliederung der Jugendlichen im Alter von 16-18 Jah…

Observation et évaluation du dispositif de formation et d'insertion des jeunes de 16 à 18 ans en Bourgogne

1983

Observation et évaluation du dispositif de formation et d'insertion des jeunes de 16 à 18 ans en Bourgogne : les entreprises et l'alternance

1984

Note critique de "De la formation initiale à la vie active. Faciliter les transitions" (OCDE). 2000

2002

International audience

Contribution of insertions and deletions to the variability of hepatitis C virus populations

2007

Little is known about the potential effects of insertions and deletions (indels) on the evolutionary dynamics of hepatitis C virus (HCV). In fact, the consequences of indels on antiviral treatment response are a field of investigation completely unexplored. Here, an extensive sequencing project was undertaken by cloning and sequencing serum samples from 25 patients infected with HCV subtype 1a and 48 patients with subtype 1b. For 23 patients, samples obtained after treatment with alpha interferon plus ribavirin were also available. Two genome fragments containing the hypervariable regions in the envelope 2 glycoprotein and the PKR-BD domain in NS5A were sequenced, yielding almost 16 000 seq…

A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology

2015

Bone morphogenetic proteins (BMPs), members of the TGF-β superfamily, have numerous biological activities including control of growth, differentiation, and vascular development. Using an in vitro co-culture endothelial cord formation assay, we investigated the role of a BMP7 variant (BMP7v) in VEGF, bFGF, and tumor-driven angiogenesis. BMP7v treatment led to disruption of neo-endothelial cord formation and regression of existing VEGF and bFGF cords in vitro. Using a series of tumor cell models capable of driving angiogenesis in vitro, BMP7v treatment completely blocked cord formation. Pre-treatment of endothelial cells with BMP7v significantly reduced their cord forming ability, indicating …

Clostridium difficile IStron CdISt1: Discovery of a Variant Encoding Two Complete Transposase-Like Proteins

2004

ABSTRACT Screening a Clostridium difficile strain collection for the chimeric element Cd ISt1 , we identified two additional variants, designated Cd ISt1 -0 and Cd ISt1 -III. In in vitro assays, we could prove the self-splicing ribozyme activity of these variants. Structural comparison of all known Cd ISt1 variants led us to define four types of IStrons that we designated Cd ISt1 -0 through Cd ISt1 -III. Since Cd ISt1 -0 encodes two complete transposase-like proteins (TlpA and TlpB), we suggest that it represents the original genetic element, hypothesized before to have originated by fusion of a group I intron and an insertion sequence element.