Search results for "integrati"

UNSUSTAINABLE LIVING. Recovery and reintegration of degraded environments

2012

Building abusiveness contributed to the progressive worsening of urban conditions and environmental crisis, generating a soil uncontrolled consumption, territory’s exploiting, bigger pollution indexes, besides the absence of building quality, levelling of languages and life models, alteration of recognising and territory belonging values, urban and extra urban landscape levelling. Building abusiveness is clearly a territorial emergency which needs technical owning to formulate sudden and effective intervention strategies. The fight against building abusiveness is still today a challenge for both environment and territory. The present volume investigates the issue of environmental decay dete…

The Lipid-Sensor Candidates CD36 and GPR120 Are Differentially Regulated by Dietary Lipids in Mouse Taste Buds: Impact on Spontaneous Fat Preference

2011

BACKGROUND: Recent studies in rodents and humans suggest that the chemoreception of long-chain fatty acids (LCFA) in oral cavity is involved in the spontaneous preference for fatty foods and might contribute to the obesity risk. CD36 and GPR120 are LCFA receptors identified in rodent taste bud cells. The fact that CD36 or GPR120 gene inactivation leads to a decrease in the preference for lipids raises the question of the respective role(s) played by these gustatory lipid-sensor candidates. METHODOLOGY/PRINCIPAL FINDINGS: Using a combination of biochemical, nutritional and behavioural studies in wild-type, CD36(+/-)and CD36(-/-) mice, it was found that: 1°) CD36 and GPR120 display different …

Matemātikas un angļu valodas integrētās mācības 11.klasē

2017

Pasaules kontekstā vārds „integrācija” jau ir zināms gadu desmitiem. Daudzas lietas un procesi ir integrēti, lai sasniegtu labākus rezultātus un izsekotu laika (gadsimta) un kultūras prasībām. Lielākā daļa cilvēku neievēro divas vai vairākas atsevišķas daļas no integrētā procesa, viņi to uzskata par vienotu veselumu. Lai noskaidrotu, kā jāorganizē matemātikas satura un angļu valodas integrētās apguves process 11.klases skolēniem, sporta ģimnāzijā tika veikts gadījuma pētījums. Ar mērķi noskaidrot, kā matemātikas un angļu valodas integrētās mācīšanas un mācīšanās procesu var īstenot un praktizēt darbā ar 11.klases skolēniem sporta ģimnāzijā, tika izveidotas dažādas aktivitātes un materiāli u…

Nessuno resta indietro: La Bellezza del Service Learning

2021

La chiusura delle scuole che ha provocato un incremento significativo della povertà educativa ha sollecitato l’opportunità di pro-gettare interventi integrati di service learning per favorire il recupero e il potenziamento dei minori in difficoltà. 869 studenti del Corso di Laurea Magistrale in Scienze della Formazione Primaria dell’Università degli Studi di Palermo, sono stati coinvolti nella progettazione e nella realizzazione di percorsi didattici mirati, rivolti agli alunni “fragili” di 33 scuole palermitane. Complessiva-mente sono state erogate 60.000 ore in DAD di attività di recupero e di potenziamento dell’apprendimento di alunni della scuola primaria di Palermo. Le attività didatti…

Stronger proprioceptive BOLD-responses in the somatosensory cortices reflect worse sensorimotor function in adolescents with and without cerebral pal…

2020

Graphical abstract

Preparing for CRIS: Challenges and Opportunities for Systems Integration at Finnish Universities

2014

Poster at Open Repositories 2014, Helsinki, Finland, June 9-13, 2014 This paper raises issues presented by integrating administrative research information to institutional repository (IR) and other systems, especially in the context of Finnish universities. The observations are based on preparing for procurement of a Current Research Information System (CRIS) at the University of Jyväskylä. The CRIS will be used by various stakeholders in different organizational units, having conflicting requirements and different notions on system usage. For example, national reporting affects considerably the publication cataloging conventions. Determining the optimal data flow for handling publications,…

2018

Synthetic materials based on calcium phosphate (CaP) are frequently used as bone graft substitutes when natural bone grafts are not available or not suitable. Chemical similarity to bone guarantees the biocompatibility of synthetic CaP materials, whereas macroporosity enables their integration into the natural bone tissue. To restore optimum mechanical performance after the grafting procedure, gradual resorption of CaP implants and simultaneous replacement by natural bone is desirable. Mg and Sr ions released from implants support osteointegration by stimulating bone formation. Furthermore, Sr ions counteract osteoporotic bone loss and reduce the probability of related fractures. The presen…

A biphasic calcium phosphate coating for potential drug delivery affects early osseointegration of titanium implants.

2016

Background Calcium phosphate (CaP) surface coatings may accelerate osseointegration and serve as a drug delivery system for mineral-binding biomolecules. In a pilot study, the impact of a commercially available, thin CaP coating on early osseous bone remodeling was compared with a modern, subtractive-treated rough surface (SLA-like) in an animal trial. Methods In 16 rabbits, 32 endosseous implants (CaP; n = 16, SLA-like; n = 16) were bilaterally inserted in the proximal tibia after randomization. After 2 and 4 weeks, bone-implant contact (BIC;%) in the cortical (cBIC) and the trabecular bone (sBIC) as well as volume of bone within the screw thread with the highest amount of new-formed bone …

Calcium Phosphate-Coated Titanium Implants in the Mandible: Limitations of the in vivo Minipig Model

2020

<b><i>Introduction:</i></b> We aimed to compare implant osseointegration with calcium phosphate (CaP) surfaces and rough subtractive-treated sandblasted/acid etched surfaces (SA) in an in vivo minipig mandible model. <b><i>Materials and Methods:</i></b> A total of 36 cylindrical press-fit implants with two different surfaces (CaP, <i>n</i> = 18; SA, <i>n</i> = 18) were inserted bilaterally into the mandible of 9 adult female minipigs. After 2, 4, and 8 weeks, we analyzed the cortical bone-to-implant contact (cBIC; %) and area coverage of bone-to-implant contact within representative bone chambers (aBIC; %). <b>&lt…

MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

2011

SummaryThe histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing translocations of the Mixed Lineage Leukemia (MLL) gene. We identified the MLL-fusion targets in an MLL-AF9 leukemia model, and conducted epigenetic profiling for H3K79me2, H3K4me3, H3K27me3, and H3K36me3 in hematopoietic progenitor and leukemia stem cells (LSCs). We found abnormal profiles only for H3K79me2 on MLL-AF9 fusion target loci in LSCs. Inactivation of Dot1l led to downregulation of direct MLL-AF9 targets and an MLL translocation-associated gene expression signature, whereas global gene expression remained largely unaffected. Suppression of MLL translocation-a…