Search results for "label"
showing 10 items of 797 documents
One-pot, direct incorporation of [11C]CO2 into carbamates.
2009
Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of (11)CO(2) with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed for the synthesis of (11)C-labeled carbamates at 75 degrees C within 10 minutes in radiochemical yields above 70% (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.
A simple, rapid method for the preparation of [11C]formaldehyde **
2008
Techniques for Biosynthesis
2015
Post-fotografia etnografica
2021
È evidente come la nostra società tecnologica sia legata senza alcun dubbio alla diffusione delle immagini. Autori come Gottfried Boehm, John Mitchell, Hans Belting hanno indagato la natura dell'immagine ponendo le basi, negli anni Novanta, per l'idea di un pictorial turn, di una cultura totalmente dominata dalle immagini che è diventata adesso una possibilità tecnica reale su scala globale. Un nuovo statuto dell'immagine che si usa raccogliere sotto l'etichetta di iconic turner inserito nel più vasto campo visual culture studies. L'uso del termine cultura accanto a quello di visuale è indicativo dell'ampiezza del campo d'indagine che visual culture studies si prefiggono di ricercare: essi …
Il tribunale per i minorenni – tra ricerca e realtà
2021
Reflection on the birth and usefulness of the courts for minors. Reference is made to the idea that delinquency can be or will be prevented through the institution of the court.
Local test of random labelling for functional marked point processes
2022
We introduce the local t-weighted marked nth-order inhomogeneous K-function, in a Functional Marked Point Processes framework. We employ the proposed summary statistics to run a local test of random labelling, useful to identify points, and consequently regions, where this assumption does not hold, i.e. the functional marks are spatially dependent.
Proteomic Analyses Reveal an Acidic Prime Side Specificity for the Astacin Metalloprotease Family Reflected by Physiological Substrates
2011
Astacins are secreted and membrane-bound metalloproteases with clear associations to many important pathological and physiological processes. Yet with only a few substrates described their biological roles are enigmatic. Moreover, the lack of knowledge of astacin cleavage site specificities hampers assay and drug development. Using PICS (proteomic identification of protease cleavage site specificity) and TAILS (terminal amine isotopic labeling of substrates) degradomics approaches >3000 cleavage sites were proteomically identified for five different astacins. Such broad coverage enables family-wide determination of specificities N- and C-terminal to the scissile peptide bond. Remarkably, me…
Automated untargeted stable isotope assisted lipidomics of liver cells on high glucose shows alteration of sphingolipid kinetics
2020
Abstract Untargeted lipidomics is a powerful tool to discover new biomarkers and to understand the physiology and pathology of lipids. The use of stable isotopes as tracers to investigate the kinetics of lipids is another tool able to supply dynamic information on lipid synthesis and catabolism. Coupling the two methodology is then very appealing in the study of lipid metabolism. The main issue to face is to perform thousands of calculations in order to obtain kinetic parameters starting from the MS raw data. An automated computerized routine able to do accomplish such task is presented in this paper. We analyzed the lipid kinetics of palmitic acid (PA) in hepatoma liver cells cultured in v…
Tissue kallikrein and kininogen in human sweat glands and psoriatic skin
1991
The cellular localization of immunoreactive tissue kallikrein and kininogen was studied in normal and psoriatic human skin. Immunoreactivity to both enzyme and substrate was observed in secretory granules of the dark cells in the secretory fundus (acinus) of the sweat glands. Double immunostaining revealed a segmental distribution of the two antigens. Each acinar section contained either tissue kallikrein or kininogen. However, there appeared to be a junctional zone in which both were present, but in separate dark cells. Immunoreactivity for both antigens was also observed in close apposition to the luminal microvilli of the duct cells. No specific immunostaining was seen in sebaceous gland…
A comparison of ensemble algorithms for item-weighted Label Ranking
2023
Label Ranking (LR) is a non-standard supervised classification method with the aim of ranking a finite collection of labels according to a set of predictor variables. Traditional LR models assume indifference among alternatives. However, misassigning the ranking position of a highly relevant label is frequently regarded as more severe than failing to predict a trivial label. Moreover, switching two similar alternatives should be considered less severe than switching two different ones. Therefore, efficient LR classifiers should be able to take into account the similarities and individual weights of the items to be ranked. The contribution of this paper is to formulate and compare flexible i…