Search results for "lean"

Physical exercise and sarcopenia in older people: position paper of the Italian Society of Orthopaedics and Medicine (OrtoMed)

2015

Sarcopenia is the age-associated loss of skeletal muscle mass and function. It is a major clinical problem for older people and research in understanding of pathogenesis, clinical consequences, management, and socioeconomic burden of this condition is growing exponentially. The causes of sarcopenia are multifactorial, including inflammation, insulin resistance, changing endocrine function, chronic diseases, nutritional deficiencies and low levels of physical activity. Operational definition of sarcopenia combines assessment of muscle mass, muscle strength and physical performance. The diagnosis of sarcopenia should be based on having a low appendicular fat free mass in combination with low …

Media-fill simulation tests in manual and robotic aseptic preparation of injection solutions in syringes

2014

Objective The purpose of this study was to evaluate the contamination rate of media-fill products either prepared automated with a robotic system (APOTECAchemo™) or prepared manually at cytotoxic workbenches in the same cleanroom environment and by experienced operators. Media fills were completed by microbiological environmental control in the critical zones and used to validate the cleaning and disinfection procedures of the robotic system. Methods The aseptic preparation of patient individual ready-to-use injection solutions was simulated by using double concentrated tryptic soy broth as growth medium, water for injection and plastic syringes as primary packaging materials. Media fills w…

Maximal isometric muscle strength and anthropometry in 75-year-old men and women in three Nordic localities

2007

Isometric maximal strength of hand grip, elbow flexion, knee extension, trunk extension and trunk flexion was studied in representative samples of 75-year-old residents of 3 Nordic localities: Glostrup in Denmark, Gothenburg in Sweden and Jyvaskyla in Finland. The study forms a part of a wider comparative research project analyzing the functional capacity and health of 75-year-olds in these towns. The strength measurements were carried out using standardized techniques and identical dynamometers. The results showed that the strength values of the limb muscles were significantly lower among the 75-year-olds in Jyvaskyla, both in absolute values and in relative units (N/kg body mass). For the…

Effects of 6 Weeks of Traditional Resistance Training or High Intensity Interval Resistance Training on Body Composition, Aerobic Power and Strength …

2020

Consistent practice of physical activity has well known positive effects on general health

Fat mass accumulation compromises bone adaptation to load in finnish women: A cross-sectional study spanning three generations

2010

Body weight and lean mass correlate with bone mass, but the relationship between fat mass and bone remains elusive. The study population consisted of 396 girls and 138 premenopausal mothers and 114 postmenopausal grandmothers of these girls. Body composition and tibial length were assessed using dual-energy X-ray absorptiometry (DXA), and bone traits were determined at the tibia using peripheral quantitative computed tomography (pQCT) in the girls at the ages of 11.2 ± 0.8, 13.2 ± 0.9, and 18.3 ± 1.0 years and in the mothers (44.7 ± 4.1 years) and grandmothers (70.7 ± 6.3 years). The values of relative bone strength index (RBSI), an index reflecting the ratio of bone strength to the load ap…

Tu1451 Medjet - A New CO2 Based Disposable Cleaning Device Allows Safe and Effective Colon Cleansing During Colonoscopy: A Prospective Open Labeled C…

2011

Beneficial Effects of Leucine Supplementation on Criteria for Sarcopenia: A Systematic Review

2019

Objective: Treating sarcopenia remains a challenge, and nutritional interventions present promising approaches. We summarize the effects of leucine supplementation in treating older individuals with sarcopenia associated with aging or to specific disorders, and we focus on the effect of leucine supplementation on various sarcopenia criteria, e.g., muscular strength, lean mass, and physical performance. Methods: A literature search for articles related to this topic was performed on the relevant databases, e.g., the PubMed/Medline, Embase, EBSCO, Cochrane, Lilacs, and Dialnet. The identified articles were reviewed according to Preferred Reporting Items for Systematic reviews and meta-analyse…

Hormone Replacement Therapy Associated White Blood Cell DNA Methylation and Gene Expression are Associated With Within-Pair Differences of Body Adipo…

2015

The loss of estrogen during menopause causes changes in the female body, with wide-ranging effects on health. Estrogen-containing hormone replacement therapy (HRT) leads to a relief of typical menopausal symptoms, benefits bone and muscle health, and is associated with tissue-specific gene expression profiles. As gene expression is controlled by epigenetic factors (including DNA methylation), many of which are environmentally sensitive, it is plausible that at least part of the HRT-associated gene expression is due to changes in DNA methylation profile. We investigated genome-wide DNA methylation and gene expression patterns of white blood cells (WBCs) and their associations with body compo…

Inhibition of the NF-κB Signaling Pathway Mediates the Anti-inflammatory Effects of Petrosaspongiolide M

2003

Petrosaspongiolide M (PT) is a potent secretory phospholipase A(2) inhibitor and anti-inflammatory agent. This marine metabolite reduced the production of nitrite, prostaglandin E(2), and tumor necrosis factor-alpha in the mouse air pouch injected with zymosan. These effects were also observed in mouse peritoneal macrophages stimulated with zymosan. Inhibition of these inflammatory mediators was related to reductions in inducible nitric oxide synthase, cyclo-oxygenase-2, and tumor necrosis factor-alpha expression. Since nuclear factor-kappaB (NF-kappaB) appears to play a central role in the transcriptional regulation of these proteins by macrophages, we investigated the effects of PT on thi…

„JESTEŚ TYM, CO JESZ” : o potędze „czystej” diety

2022

W artykule opisana została jedna z bardziej popularnych obecnie diet, określana mianem prozdrowotnej, tak zwana czysta dieta. Polega ona na eliminacji dostarczania organizmowi między innymi żywności przetworzonej, którą uznaje się za nieczystą, a tym samym szkodliwą i niebezpieczną dla zdrowia człowieka. Obszarem badań objęto blogi i strony internetowe poświęcone temu zagadnieniu, a także wpisy w mediach społecznościowych. W tekście wskazuje się na kulturowe konteksty czystej diety, powody jej popularności, jej powiązanie ze stylem życia i aksjologizowaniem pokarmów oraz na konsekwencje, do jakich stosowanie czystej diety może doprowadzić.