Search results for "levan"
showing 10 items of 672 documents
Coupling News Sentiment with Web Browsing Data Improves Prediction of Intra-Day Price Dynamics
2015
The new digital revolution of big data is deeply changing our capability of understanding society and forecasting the outcome of many social and economic systems. Unfortunately, information can be very heterogeneous in the importance, relevance, and surprise it conveys, affecting severely the predictive power of semantic and statistical methods. Here we show that the aggregation of web users' behavior can be elicited to overcome this problem in a hard to predict complex system, namely the financial market. Specifically, our in-sample analysis shows that the combined use of sentiment analysis of news and browsing activity of users of Yahoo! Finance greatly helps forecasting intra-day and dai…
The prognostic relevance of HER2-positivity gain in metastatic breast cancer in the ChangeHER trial
2021
Breast cancer (BC) heterogeneity is composite in nature, with a wide variety of factors concurring to define several pathological entities, which differ by clinical presentation, pathologic features, therapy administered, and inherent outcomes1. Additional sources of breast cancer heterogeneity may raise during the disease course. In BC patients whose disease was initially diagnosed in the early stage and subsequently progressed with metastatic involvement of one single or multiple site/s, the molecular characteristics of metastatic lesions do not necessary mimic those of the disease initially diagnosed. A well-depicted molecular landscape is crucial for subtype definition, prognostic evalu…
Prospective multicenter real-world RAS mutation comparison between OncoBEAM-based liquid biopsy and tissue analysis in metastatic colorectal cancer
2018
[EN] BACKGROUND: Liquid biopsy offers a minimally invasive alternative to tissue-based evaluation of mutational status in cancer. The goal of the present study was to evaluate the aggregate performance of OncoBEAM RAS mutation analysis in plasma of colorectal cancer (CRC) patients at 10 hospital laboratories in Spain where this technology is routinely implemented. METHODS: Circulating cell-free DNA from plasma was examined for RAS mutations using the OncoBEAM platform at each hospital laboratory. Results were then compared to those obtained from DNA extracted from tumour tissue from the same patient. RESULTS: The overall percentage agreement between plasma-based and tissue-based RAS mutatio…
One-Cell Doubling Evaluation by Living Arrays of Yeast, ODELAY!
2016
Abstract Cell growth is a complex phenotype widely used in systems biology to gauge the impact of genetic and environmental perturbations. Due to the magnitude of genome-wide studies, resolution is often sacrificed in favor of throughput, creating a demand for scalable, time-resolved, quantitative methods of growth assessment. We present ODELAY (One-cell Doubling Evaluation by Living Arrays of Yeast), an automated and scalable growth analysis platform. High measurement density and single-cell resolution provide a powerful tool for large-scale multiparameter growth analysis based on the modeling of microcolony expansion on solid media. Pioneered in yeast but applicable to other colony formin…
FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices.
2021
International audience; Single-molecule FRET (smFRET) has become a mainstream technique for studying biomolecular structural dynamics. The rapid and wide adoption of smFRET experiments by an ever- increasing number of groups has generated significant progress in sample preparation, measurement procedures, data analysis, algorithms and documentation. Several labs that employ smFRET approaches have joined forces to inform the smFRET community about streamlining how to perform experiments and analyze results for obtaining quantitative information on biomolecular structure and dynamics. The recent efforts include blind tests to assess the accuracy and the precision of smFRET experiments among d…
Bilateral Bifid mandibular canals ? Special relevance for a general dental practitioner. Report of 2 cases
2019
Dental practitioners may encounter bifid mandibular canals upon radiographic assessment, and may not understand the true extent of this presentation. The presentation of a bifid mandibular canal poses difficulties when carrying out dental procedures, including administration of mandibular block anaesthesia, oral surgical procedures of the lower third molars, orthognathic surgery and implant placement. Therefore it is of paramount importance that general dental practitioners be aware of the radiographic appearance, as incorrect diagnosis of this rare presentation can lead to detrimental consequences. The purpose of the communication is to draw dental practitioner’s attention to the variation…
ACTIVIDAD FÍSICA Y DISCAPACIDAD: UN ESTUDIO CUALITATIVO CON MUJERES EN UN GIMNASIO ADAPTADO
2017
Este estudio explora cómo un grupo de mujeres con discapacidad (n=6) experimentan y perciben la práctica de actividad física en un gimnasio adaptado. Se utilizaron entrevistas semi-estructuradas como instrumento de recogida de datos cualitativos y se realizó un análisis temático inductivo. Los resultados se agruparon en torno a cuatro categorías temáticas emergentes: condición física y autonomía personal; papel paliativo del ejercicio; bienestar psicológico; relación social y apoyo. Destaca la experiencia satisfactoria de las participantes, en la que predomina una valoración positiva de procesos autorregulativos, la concepción social-relacional de la actividad física, y la relevancia del gi…
Multidisciplinary integrated approach for older adults with symptomatic osteoarthritis: SIMFER and SI-GUIDA Joint Position Statement.
2020
Multidisciplinary approach to osteoarthritis (OA) in older patients, whose functional decline is multifactorial and who present with multiple symptoms, has been long advocated, but it is still seldom implemented in daily practice. Therefore, further indications for the management of OA are eagerly awaited and should consider the specific clinical features of this population, including the presence of frailty and comorbidities. This clinical approach should be based both on well-grounded evidence and practical experience of experts in OA management. This manuscript comments the multidisciplinary integrated approach for OA management in the older population, according to the opinion of a mult…
Evaluation of geomorphometric characteristics and soil properties after a wildfire using Sentinel-2 MSI imagery for future fire-safe forest
2021
Abstract Understanding spatiotemporal geomorphological and pedological changes as a consequence of wildfires can allow stakeholders, land planners, and policymakers to design efficient fire safety-based afforestation and restoration programs of forest lands. The use of remote sensing techniques is a key tool to achieve this goal. The suitable combination of Sentinel-2 MSI data for mapping of different spectral indices related to burn severity and their relationship with other morphometric and soil properties can contribute to a better understanding of the impact of fire, and this is relevant in regions where is still scarce fire-related research such as Turkey. In this investigation, the us…
Assessing Teacher’s Discourse Effect on Students’ Learning: A Keyword Centrality Approach
2020
The way that content-related keywords co-occur along a lesson seems to play an important role in concept understanding and, therefore, in students’ performance. Thus, network-like structures have been used to represent and summarize conceptual knowledge, particularly in science areas. Previous work has automated the process of producing concept networks, computed different properties of these networks, and studied the correlation of these properties with students’ achievement. This work presents an automated analysis of teachers’ concept graphs, the distribution of relevance amongst content-related keywords and how this affects students’ achievement. Particularly, we automatically extracted…