Search results for "ley"

La crisis de la ley en Luigi Ferrajoli: algunas consideraciones desde la teoría de la legislación

2012

La preocupación por la calidad de las normas es una cuestión cada vez más presente en nuestro tiempo. La obra Principia iuris del profesor Ferrajoli no es una excepción. En ella se diagnostican problemas tales como el lenguaje oscuro de las normas, la legislación penal con carácter simbólico, la inflación normativa o el colapso de los tribunales. Ante tales circunstancias, en la obra señalada se proponen varias soluciones. El objetivo de este trabajo es analizar algunas de estas propuestas desde la perspectiva de la teoría de la legislación. Este ejercicio puede resultar interesante, por cuanto con él es posible contribuir al desarrollo de las propuestas de Ferrajoli, matizar algunas de ell…

Her Mistress's Voice: Gynophonocentrism in Feminist Discourses

2000

I will trace the metaphors of voice in the discourses of feminisms as articulated by Judith Fetterley, Kaja Silverman, Julia Kristeva, and Hélène Cixous. I will analyze the presuppositions of their vocal or sound imagery, paying special attention to the implications of the essentialism/constructivism opposition. It is not my intention to provide a comprehensive account of voice in feminisms, nor to make sweeping generalizations on the basis of a very limited corpus. Moreover, in spite of their differences in cultural background, period, and main area of study, the four theorists to be read are, as it were, within earshot from each other, centering, whether anglo- or francophone, around the …

The FBN2 gene: new mutations, locus-specific database (Universal Mutation Database FBN2), and genotype-phenotype correlations.

2009

International audience; Congenital contractural arachnodactyly (CCA) is an extremely rare disease, due to mutations in the FBN2 gene encoding fibrillin-2. Another member of the fibrillin family, the FBN1 gene, is involved in a broad phenotypic continuum of connective-tissue disorders including Marfan syndrome. Identifying not only what is in common but also what differentiates these two proteins should enable us to better comprehend their respective functions and better understand the multitude of diseases in which these two genes are involved. In 1995 we created a locus-specific database (LSDB) for FBN1 mutations with the Universal Mutation Database (UMD) tool. To facilitate comparison of …

Laparoscopic endopelvic sacral implantation of a Brindley controller for recovery of bladder function in a paralyzed patient

2008

Background: A number of techniques are being investigated to accomplish bladder control recovery in paralyzed patients using the neurostimulation, but currently, all techniques are based on the dorsal implantation of the electrodes using a laminectomy. Methods: On 27 April 2006 we performed a laparoscopic implantation of a Finetech-Brindley bladder controller on the endopelvic sacral roots in a Th8 completely paralyzed woman who had previously undergone the removal of a Brindley controller due to an arachnoiditis after extrathecal implantation with intradural sacral deafferentation. Results: We required about 3.5 h for the entire surgical procedure; no complications occurred and the patient…

Le flotte degli Austrias e gli scali italiani: una messa a punto

2019

Since the sixteenth century, the threat of Ottoman armies and Barbary corsairs forced Spain to gradually equip and upgrade a fleet of galleys - organized in teams - which in the "Italian" geopolitical space was headed by the domains that had a maritime projection (Kingdoms of Naples, Sicily, Sardinia) and the "connected" port of Genoa. Furthermore, new territories (the State of the Presidi, the feudal enclave of Finale) were acquired to facilitate navigation within the western Mediterranean borders and the use of Ligurian ports was negotiated with the Republic of Genoa. The maritime war in its various forms was therefore at the base of an elaborate logistic and strategic organization, which…

Phonon-driven spin-Floquet magneto-valleytronics in MoS2

2018

AbstractTwo-dimensional materials equipped with strong spin–orbit coupling can display novel electronic, spintronic, and topological properties originating from the breaking of time or inversion symmetry. A lot of interest has focused on the valley degrees of freedom that can be used to encode binary information. By performing ab initio time-dependent density functional simulation on MoS2, here we show that the spin is not only locked to the valley momenta but strongly coupled to the optical E″ phonon that lifts the lattice mirror symmetry. Once the phonon is pumped so as to break time-reversal symmetry, the resulting Floquet spectra of the phonon-dressed spins carry a net out-of-plane magn…

Evaluation of P-glycoprotein (abcb1a/b) modulation of [18F]fallypride in MicroPET imaging studies

2012

[(18)F]Fallypride ([(18)F]FP) is an important and routinely used D2/D3 antagonist for quantitative imaging of dopaminergic neurotransmission in vivo. Recently it was shown that the brain uptake of the structurally related [(11)C]raclopride is modulated by P-glycoprotein (P-gp), an important efflux transporter at the blood-brain barrier. The purpose of this study was to determine whether the brain uptake of [(18)F]FP is influenced by P-gp. For examination of this possible modulation microPET studies were performed in a rat and a mouse model. Hence, [(18)F]FP was applied to Sprague Dawley rats, half of them being treated with the P-gp inhibitor cyclosporine A (CsA). In a second experimental s…

Synthesis and evaluation of (S)-2-(2-[18F]fluoroethoxy)-4-([3-methyl-1-(2-piperidin-1-yl-phenyl)-butyl-carbamoyl]-methyl)-benzoic acid ([18F]repaglin…

2004

18F-labeled non-sulfonylurea hypoglycemic agent (S)-2-(2-[(18)F]fluoroethoxy)-4-((3-methyl-1-(2-piperidin-1-yl-phenyl)-butylcarbamoyl)-methyl)-benzoic acid ([(18)F]repaglinide), a derivative of the sulfonylurea-receptor (SUR) ligand repaglinide, was synthesized as a potential tracer for the non-invasive investigation of the sulfonylurea 1 receptor status of pancreatic beta-cells by positron emission tomography (PET) in the context of type 1 and type 2 diabetes. [(18)F]Repaglinide could be obtained in an overall radiochemical yield (RCY) of 20% after 135 min with a radiochemical purity higher than 98% applying the secondary labeling precursor 2-[(18)F]fluoroethyltosylate. Specific activity w…

The DAT ligand [(18)F]PR17.MZ mirrors the in vivo pharmacokinetic profile of [(11)C]cocaine with significantly improved monoamine transporter selecti…

2010

Selective binding to monoamine oxidase A: in vitro and in vivo evaluation of (18)F-labeled β-carboline derivatives.

2015

In this study we synthesized four different (18)F-labeling precursors for the visualization of the monoamino oxidase A using harmol derivatives. Whereas two are for prosthetic group labeling using [(18)F]fluoro-d2-methyl tosylate and 2-[(18)F]fluoroethyl-tosylate, the other three precursors are for direct nucleophilic (18)F-labeling. Additionally the corresponding reference compounds were synthesized. The syntheses of [(18)F]fluoro-d2-methyl-harmol and 2-[(18)F]fluoroethyl-harmol were carried out using harmol as starting material. For direct nucleophilic (18)F-labeling of the tracers carrying oligoethyled spacers (PEG), a toluenesulfonyl leaving group was employed. The radiolabeling, purifi…