Search results for "lh"

A Novel Series of Acylhydrazones as Potential Anti-Candida Agents: Design, Synthesis, Biological Evaluation and In Silico Studies

2019

In the context of an increased incidence of invasive fungal diseases, there is an imperative need of new antifungal drugs with improved activity and safety profiles. A novel series of acylhydrazones bearing a 1,4-phenylene-bisthiazole scaffold was designed based on an analysis of structures known to possess anti-Candida activity obtained from a literature review. Nine final compounds were synthesized and evaluated in vitro for their inhibitory activity against various strains of Candida spp. The anti-Candida activity assay revealed that some of the new compounds are as active as fluconazole against most of the tested strains. A molecular docking study was conducted in order to evaluate the …

Polyaspartylhydrazide Copolymer-Based Supramolecular Vesicular Aggregates as Delivery Devices for Anticancer Drugs

2008

In this paper we report on three different hydrophilic copolymers based on alpha,beta-polyaspartylhydrazide (PAHy) bearing butyric groups in the side chain (C 4) (PAHy-C 4) or a combination of butyric groups and positive charged residues ((carboxypropyl)trimethylammonium chloride, CPTACl) (PAHy-C 4-CPTA) that were synthesized and used for the preparation of new supramolecular vesicular aggregates (SVAs) containing gemcitabine as an antitumor drug. Gemcitabine-loaded SVAs containing synthesized PAHy derivatives were characterized from the physicochemical and technological point of view and the in vitro toxicity and anticancer activity on two different human cancer cell lines, i.e., CaCo-2 (h…

Glutathione metabolism in skeletal muscle derived cells of the L6 line

1993

Skeletal muscle derived L6 myoblasts possess a considerably high resting total glutathione (TGSH) pool. Exposure to L-buthionine-[S,R]-sulphoximine resulted in a 90% depletion of the intracellular TGSH pool. All the key enzymes of glutathione metabolism, especially glutathione S-transferase, were observed to be considerably active in the undifferentiated cells. Se-dependent glutathione peroxidase activity appeared to account for most of the total GSH peroxidase activity of the cells. A significant contribution of gamma-glutamyl transpeptidase-independent (5 mM acivicin insensitive) mechanism to the extracellular GSH uptake capacity of the muscle cells was evident. Efflux of oxidized glutath…

Mity antyczne we francuskim dramacie XX wieku (na wybranych przykładach)

2017

The French theatre of the 20th century willingly treats and revisits ancient myths. Oedipus, Antigone, Electra, the Trojan War, Amphitryon appear in many writers’ works. The myth of Electra in Jean Giraudouxs version entitled Electra (1937), as well as Jean-Paul Sartres The Flies (1942) are interesting examples of metatexts. Face to the threat of war, Giraudoux, who was a diplomat and a Germanophile, focuses on the problem of power, responsibility, and justice, while Sartre exemplifies the existentialist philosophy and its main element: a man who is responsible for his actions and condemned to freedom. This was a particular challenge during the period of war and occupation. Jean Anouilh, in…

Contributo para o estudo psicométrico da versão portuguesa do Cuestionario de Satisfacción Laboral S20/23

2010

Job satisfaction is understood through its dual role on organization productivity and employees achievement (Smith, 1998). The use of instruments to measure it in Portugal, has been the subject of several studies, such as the adaptation of the Cuestionario de Satisfacción Laboral S20/23 (Meliá & Peiró, 1989) to Portuguese population carried out by Pocinho and García (2008). This study is a further contribution to the study of the psychometric qualities of this instrument. The results on a sample of 136 Portuguese employees show that the questionnaire presents the adequate requirements of internal consistency (.95), test-retest reliability, and convergent validity (correlation of .84 with th…

Pronubi selvatici ed api nell'impollinazione in colture protette di melone (Cucumis melo var. inodorus Naud, C. m. reticulatus Ser.)in Sicilia occide…

2002

CCDC 113469: Experimental Crystal Structure Determination

2000

Related Article: F.Hueso-Urena, A.L.Penas-Chamorro, M.N.Moreno-Carretero, J.M.Amigo, V.Esteve, T.Debaerdemaeker|1999|Polyhedron|18|2205|doi:10.1016/S0277-5387(99)00108-4

The Vuelo Ruiz de Alda (1929-30): an exceptional cartographic document. Again about Ilici

2015

Se presenta en este artículo una primera valoración de las posibilidades que para la arqueología, y más concretamente para la estratigrafía del paisaje, encierra un soberbio documento como es la serie fotográfica conocida como Vuelo Ruiz de Alda (1929-30), una vez que los fotogramas han sido ampliamente puestos al alcance de la investigación. Para ello se ponen a prueba las imágenes aplicándolas a dos establecimientos de época ibérica antigua (El Oral y El Molar). Igualmente, se ha retomado una línea de investigación a propósito de la red caminera que afecta al enclave de La Alcudia-Ilici, lo que lleva implícitamente a tratar sobre su catastro romano y la trama parcelaria de todo su entorno…

Über die frühen Werke von Carl Gotthard Graß in der Akademischen Bibliothek der Universität Lettlands, über die Freundschaft, Antiquarismus in der Ge…

2020

Pose classification using support vector machines

2000

In this work a software architecture is presented for the automatic recognition of human arm poses. Our research has been carried on in the robotics framework. A mobile robot that has to find its path to the goal in a partially structured environment can be trained by a human operator to follow particular routes in order to perform its task quickly. The system is able to recognize and classify some different poses of the operator's arms as direction commands like "turn-left", "turn-right", "go-straight", and so on. A binary image of the operator silhouette is obtained from the gray-level input. Next, a slice centered on the silhouette itself is processed in order to compute the eigenvalues …