Search results for "lino"
showing 10 items of 1310 documents
Epifanie isolane: Bufalino,il giovane artista e Joyce
2010
Fasti seicenteschi nella scrittura di Gesualdo Bufalino
2009
Il saggio esamina le peculiarità del barocco dissonante di Gesualdo Bufalino. In Bufalino l’artificio dello stile sottende una tensione ideologica. L’intensità espressiva e l’eccesso verbale cercano di compensare un vuoto e costituiscono, nel sentire dello scrittore, un formidabile mezzo «per contrastare l’ossificazione del mondo». Bufalino rivendica quindi il valore strutturale della propria scelta barocca, dichiarando che la sua scrittura è sorretta da un «barocco borrominiano» in cui «l’ornato è funzione», in mancanza del quale «l’architettura cadrebbe».
‹‹Una scherma amorosa››: Bufalino e il lettore
2011
Il saggio indaga le modalità con cui Bufalino indirizza e controlla a distanza il processo di lettura delle proprie opere, Congegnando un intrigante gioco di specchi, di rifrazioni e di mise en abyme, l’autore inserisce all’interno della narrazione episodi e apologhi allegorici, che compendiano in sé l’intero senso del racconto e mettono in scene figure di lettori. L’attenzione del lettore, messa in allerta dalle spie disseminate a bella posta nel testo, è convogliata spesso su una traiettoria per certi versi ‘obbligata’: muovendo dagli indizi predisposti con avvedutezza dal narratore l’interpretazione si concentra giocoforza su certi nodi significativi, mettendo da parte gli altri, eventua…
«Bracconiere di ricordi». Memoria e oblio in Gesualdo Bufalino
2021
The essay aims to analyze the connection between memory and oblivion that Bufalino investigates in his inventive work. Memory and its reverse, forgetfulness, are important themes of a writing that questions itself on the very reasons for its making. Bufalino’s narrative is populated with characters without a past, constructed by subtraction, through a chiaroscuro made up of full and above all voids, omissions, erasures. In the stories of the book L’uomo invaso e altre invenzioni the ghosts of oblivion and the emblematic images of erased memory, of the bleeding of memories affected by «wounds of passing time» coexist with references to the literary character of the “forgetful”, who suffers f…
Sulfated Lupane Triterpene Derivatives and a Flavone C-Glycoside from Gypsophila repens
2007
A new sulfated lupane triterpene, Gypsophilin (1), and its glucosyl ester, Gypsophilinoside (2) were isolated from the roots of Gypsophila repens whereas a new flavone C-glycoside (3) was obtained from the aerial parts. Their structures were established as (3beta)-3-O-(sulfo)lup-20(29)-en-23,28-dioic acid (1), (3beta)-3-O-(sulfo)lup-20(29)-en-23,28-dioic acid -28-O-beta-D-glucopyranosyl ester (2) and luteolin-7-O-alpha-L-arabinopyranosyl-6-C-beta-glucopyranoside (3) by spectroscopic methods such as 1D and 2D NMR, HR-ESI-MS and FAB-MS.
CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis.
2014
SummaryCancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) express CD44v6, which is required for their migration and generation of metastatic tumors. CD44v6 expression is low in primary tumors but demarcated clonogenic CR-CSC populations. Cytokines hepatocyte growth factor (HGF), osteopontin (OPN), and stromal-derived factor 1α (SDF-1), secreted from tumor associated cells, increase CD44v6 expression in CR-CSCs by activating the Wnt/β-catenin pathway, which promotes migration and metastasis. CD44v6− progenitor cells do not give rise to metastatic lesions but, when…
The rs1527483, but not rs3212018, CD36 polymorphism associates with linoleic acid detection and obesity in Czech young adults
2018
AbstractRecent evidence has raised the possibility of the existence of a sixth taste modality – that is, taste for fat – which is mediated by lingual CD36 and plays a role in obesity. Consequently, the genetic polymorphism of CD36 has been shown to be associated with altered oro-sensory detection of dietary lipids. In the present study, we investigated the relationship between oro-sensory perception of linoleic acid (LA), two CD36 polymorphisms (rs1527483 and rs3212018), obesity parameters and craving habits for dietary lipids in young Czech adults. We also sequenced 5 and 6 exons of CD36 to trace out any new mutation that might be responsible for the difference in taste perception. We obse…
Decreasing dietary linoleic acid promotes long chain omega-3 fatty acid incorporation into rat retina and modifies gene expression
2011
International audience; Age-related macular degeneration (AMD) may be partially prevented by dietary habits privileging the consumption of ω3 long chain polyunsaturated fatty acids (ω3s) while lowering linoleic acid (LA) intake. The present study aimed to document whether following these epidemiological guidelines would enrich the neurosensory retina and RPE with ω3s and modulate gene expression in the neurosensory retina. Rat progenitors and pups were fed with diets containing low or high LA, and low or high ω3s. After scotopic single flash and 8-Hz-Flicker electroretinography, rat pups were euthanized at adulthood. The fatty acid profile of the neurosensory retina, RPE, liver, adipose tis…
Oro-gustatory perception of dietary lipids and calcium signaling in taste bud cells are altered in nutritionally obesity-prone Psammomys obesus.
2013
Since the increasing prevalence of obesity is one of the major health problems of the modern era, understanding the mechanisms of oro-gustatory detection of dietary fat is critical for the prevention and treatment of obesity. We have conducted the present study on Psammomys obesus, the rodent desert gerbil which is a unique polygenic natural animal model of obesity. Our results show that obese animals exhibit a strong preference for lipid solutions in a two-bottle test. Interestingly, the expression of CD36, a lipido-receptor, in taste buds cells (TBC), isolated from circumvallate papillae, was decreased at mRNA level, but remained unaltered at protein level, in obese animals. We further st…
Upregulation of liver VLDL receptor and FAT/CD36 expressions in LDLR-/- apoB100/100 mice fed trans-10,cis-12 conjugated linoleic acid
2006
International audience; This study explores the mechanisms responsible for the fatty liver setup in mice fed trans-10,cis-12 conjugated linoleic acid (t10c12 CLA), hypothesizing that an induction of low density lipoprotein receptor (LDLR) expression is associated with lipid accumulation. To this end, the effects of t10c12 CLA treatment on lipid parameters, serum lipoproteins, and expression of liver lipid receptors were measured in LDLR(-/-) apoB(100/100) mice as a model of human familial hypercholesterolemia itself depleted of LDLR. Mice were fed t10c12 CLA over 2 or 4 weeks. We first observed that the treatment induced liver steatosis, even in the absence of LDLR. Mice treated for 2 weeks…