Search results for "live"

Latest insight into factors that affect food perception in older adults

2016

Revue; Latest insight into factors that affect food perception in older adults. Food Matters Live: Meeting the sensory capabilities of the older consumer

Warming temperatures and ectoparasitic sea lice impair internal organs in juvenile Atlantic salmon

2021

As a consequence of climate change and open net-pen salmon farming, wild Atlantic salmon Salmo salar are increasingly likely to encounter elevated temperatures and parasite abundances during their early marine migration. Such stressors can compromise fitness by diminishing liver energy stores and impairing cardiac muscle. To assess whether temperature and infestation by salmon lice Lepeophtheirus salmonis are important correlates of liver energy stores and cardiac muscle performance in juvenile salmon, we experimentally infested fish at 3 abundances of louse infestation (zero, low, and high) and 5 temperatures (10, 13, 16, 19, and 22°C). At the end of the experiment (i.e. when sea lice reac…

L'interaction lieu – objet comme modélisation de l'expérience culturelle vécue : définition, mesure et validation empirique dans le cas du spectacle …

2006

This article proposes to reconsider the concept of lived cultural experience. In a first part, we explore the track of value. We try to justify of its interest to apprehend the experience. We also seek to improve the conceptualization of the experience by defining it as an interaction place - object. Then, in a second part, we present an empirical test of this conceptualization in the field of lives performance. This test is followed of a discussion about the results.

Are Public Subsidies to Encourage Young Farmers Effective? Case Study of a First-Time Farm Set Up by a Young Female Farmer in the Valencian Region of…

2021

Generational renewal and the incorporation of women into the rural world are fundamental for the sustainability and modernisation of the agricultural sector. Hence the special government protection granted to the sector, which appears in both European legislation on rural issues and in the global strategy of the 2030 Agenda and the Sustainable Rural Development Goals involving a commitment to measures aimed at helping young farmers to set up agricultural holdings and especially at encouraging women to engage in farm management. In the case of Spain, this is nothing new, given that Law 35/2011 on the Shared Ownership of Agricultural Holdings became a veritable revolution in terms of gender i…

Testing the Modified Sediment Delivery Model (MOSEDD) at SPA2 Experimental Basin, Sicily (Italy)

2017

A new version of a spatially distributed sediment delivery model taking into account the hillslope sediment transport efficiency, named MOSEDD, is presented. This model gives estimates of basin sediment yield at event scale, which are more reliable than those obtained by the original SEDD. For SPA2 basin discretized into morphological units, four different calculation schemes of MOSEDD, including the original SEDD version, were applied. All parameterization schemes of the model were calibrated using 15 events measured at the outlet of the experimental basin in the period February 2005–February 2010. The model calibration was used to determine a relationship between the coefficient βe of the…

Sexual selection on song and cuticular hydrocarbons in two distinct populations of Drosophila montana

2011

Sexual selection has the potential to contribute to population divergence and speciation. Most studies of sexual selection in Drosophila have concentrated on a single signaling modality, usually either courtship song or cuticular hydrocarbons (CHCs), which can act as contact pheromones. We have examined the relationship between both signal types and reproductive success using F1–3 offspring of wild- collected flies, raised in the lab. We used two populations of the Holarctic species Drosophila montana that represent different phylogeographic clades that have been separate for ca. 0.5 million years (MY), and differ to some extent in both traits. Here, we characterize the nature and identify …

Delivery of shNupr1 plasmid by solid lipid nanoparticles reduces the expression of Nupr1 gene in hepatocellular carcinoma cells

2015

Polymeric nanoparticles for siRNA delivery: Production and applications

2017

Gene therapy through the use of siRNA and a polymeric carrier are becoming an efficient therapeutic option to conventional pharmaceutical formulations for the treatment of deadly diseases, such as cancer, pulmonary, ocular and neurodegenerative diseases. However, several considerations regarding the stability, formulation, and efficacy have to be faced up until these systems could be considered to be a marketable pharmaceutical products for to extend siRNA application to clinical practice. This review is focused on the key challenges of siRNA therapeutics, with special attention on the faced obstacles and on the formulation-related difficulties, providing a list of requirements needed for o…

Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.

2021

Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…

Development of different nanosystems for drugs and siRNA delivery

Cancer is one of the leading causes of death in the world. Over the past several decades, the development of engineered nanosystems for targeted drug delivery have received great attention thanks to their possibility to overcome the limitations of classical cancer chemotherapy including poor solubility, targeting incapability, nonspecific action and, consequently, systemic toxicity. In this contest, four different models of nanocarriers have been analysed and compared for their capacity to target tumour tissue and to release the therapeutic agent in a controlled way: INU-EDA-P,C-DOXO; PHEA-EDA-P,C-DOXO; PVP-siRNA and RGO-siRNA. Inulin and PHEA were conjugated to the antineoplastic drug doxo…