Search results for "locu"
showing 10 items of 751 documents
Psychological Distance in Eleonora Duse’s Medievalism
2017
Arthur Symons (1865–1945) remarked that the acting of Eleonora Duse (1858–1924) was ‘a criticism’, and that she enriched the roles she played. In doing so she fulfilled the author’s intention as well as conveying the character’s tragic passion. In my previous studies on Duse I have explored intensively the explanation of why her acting was such a perfect blend of erudition and skilful vocalisation, giving her the methodology to create an individual character in every part she played. Undoubtedly, she was a cerebral actress and a grand tragedienne. On the one hand, she was able to use all the depths and tones of her voice to generate extraordinarily melodious elocution – hers was a seductive…
Mpdz is a quantitative trait gene for drug withdrawal seizures
2004
Physiological dependence and associated withdrawal episodes can constitute a powerful motivational force that perpetuates drug use and abuse. Using robust behavioral models of drug physiological dependence in mice, positional cloning, and sequence and expression analyses, we identified an addiction-relevant quantitative trait gene, Mpdz. Our findings provide a framework to define the protein interactions and neural circuit by which this gene's product (multiple PDZ domain protein) affects drug dependence, withdrawal and relapse.
Les nuées dynamiques floues appliquées au développement dune typologie paysagère
2007
International audience; Un programme d'épidémiosurveillance actuellement en cours vise à évaluer la présence du parasite Echinococcus multilocularis en France. Contrairement aux hypothèses écologiques initiales, le parasite et ses hôtes ne semblent pas privilégier certains modes d'occupation du sol plus que d'autres. L'objectif de ce travail consiste à identifier dans un premier temps les contextes paysagers au sein desquels la présence parasitaire est confirmée puis, dans un second temps, à mettre en évidence un gradient dans les prévalences spécifiques à chacun de ces contextes. Les nuées dynamiques floues ont permis d'optimiser et de critiquer la typologie paysagère établie. La hiérarchi…
Is the PGM1 locus subject to selection?
1973
The placental phosphoglucomutase phenotypes controlled by the first locus of 235 German and 119 non-German samples were determined. Both in the pooled material and in the sample containing German subjects only there was a significant deviation from the expected Hardy-Weinberg equilibrium. A segregation analysis of 1174 families also revealed significant deviations in the phenotypes of the children, though the mating frequencies were as expected. The distribution of the children's phenotypes deviated significantly from Hardy-Weinberg equilibrium though this was not found in the parent samples. The results are discussed.
Genetic basis of human complement C4A deficiency. Detection of a point mutation leading to nonexpression.
1993
Abstract The fourth component of the human complement system (C4) is coded for by two genes, C4A and C4B, located within the MHC. Null alleles of C4 (C4Q0) are defined by the absence of C4 protein in plasma. These null alleles are due either to large gene deletions or to nonexpression of the respective genes. In a previous study, evidence was obtained for nonexpressed defective genes at the C4A locus, and for gene conversion at the C4B locus. To further characterize the molecular basis of these non-expressed C4A genes, we selected nine pairs of PCR primers from flanking genomic intron sequences to amplify all 41 exons from individuals with a defective C4A gene. The amplified products were s…
Emotivity in Valencian demonstratives
2022
Més que una proximitat metafòrica cap al referent, la dixi emotiva, afectiva o empàtica produeix proximitat cap a l’oient arran de l’atenció conjunta i/o l’avaluació del referent. Aquest treball estudia els usos del demostratiu (com ara, la funció nominal o adverbial, el grau, el mode referencial, el caràcter humà, etc.) i de les seues construccions (anteposades al nom, posposades al nom o sense nucli nominal) per a comprovar quin tipus de demostratius tendeixen a tindre referents que són valorats de manera positiva o negativa. Per a realitzar aquesta exploració, hem recollit 383 formes demostratives d’un corpus propi (CoValC) format per converses col·loquials entre valencianoparlants de di…
Insight into the Evolving Role of PCSK9
2022
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the last discovered member of the family of proprotein convertases (PCs), mainly synthetized in hepatic cells. This serine protease plays a pivotal role in the reduction of the number of low-density lipoprotein receptors (LDLRs) on the surface of hepatocytes, which leads to an increase in the level of cholesterol in the blood. This mechanism and the fact that gain of function (GOF) mutations in PCSK9 are responsible for causing familial hypercholesterolemia whereas loss-of-function (LOF) mutations are associated with hypocholesterolemia, prompted the invention of drugs that block PCSK9 action. The high efficiency of PCSK9 inhibitors (…
Every Silver Lining Has a Cloud: An Empirical Analysis of the Role of Neutralization Techniques Within the Context of Moral Intensity
2017
This study addresses a research gap in the literature of ethical decision-making which deals with the mediating role of central neutralization techniques between incidents of different severity and resulting consumer attitudes toward the company. It is widely accepted that irresponsible company actions effect consumer actions and attitudes toward the company in an unfavorable way. Yet, reality proves that this is only partly true, revealing moderate negative consequences for companies in scandalous situations. Consumers do not completely transfer their proethical attitude in actual purchase behavior, which leads to an attitude-behavior gap. We aim at explaining the psychological concepts ly…
THE INDICATORS OF LOCUS OF CONTROL IN THE SMALL BUSINESS CONTEXT
2000
There have been divergent opinions as to the suitability of the various indicators of locus of control in business management research. This study examines how the indicators of internal locus and strategic locus of control function in the small business context. The study examines first the interrelations between these indicators and then relation between each of the indicators and the firm's strategic factors. The indicators of locus of control differed from each other in their relation to external control. The indicator of strategic locus of control correlated with the firm's targets, strategic decision-making and success. On the other hand the indicator of internal locus of control is …
"Fósiles fraseológicos”: la configuración formal de “voces fósiles” como palabras idiomáticas en locuciones españolas = “Phraseological fossils”: mor…
2020
En el presente trabajo pretendemos ofrecer un análisis de la configuración formal del tipo de palabras idiomáticas que denominamos “fósiles fraseológicos”. Para ello, tras delimitar los conceptos de “palabra idiomática” y “fósil fraseológico”, se aclaran los procedimientos metodológicos para recopilar este tipo de voces en un diccionario general actual como el DLE, y se procede al análisis del corpus obtenido. El principal rasgo de los fósiles fraseológicos es que presentan los cambios evolutivos característicos de la evolución del latín al español, como voces patrimoniales que son.The objective of this paper is to offer an analysis of the morphology of the kind of idiomatic words that we c…