6533b825fe1ef96bd1282881
RESEARCH PRODUCT
Is the PGM1 locus subject to selection?
R. AnanthakrishnanH. WalterW. Becksubject
ElectrophoresisErythrocytesDenmarkPlacentaLocus (genetics)BiologyGermanPregnancyPGM1GeneticsHumansMetabolic diseaseSelection GeneticMolecular BiologyGenetics (clinical)GeneticsPolymorphism GeneticGermany WestBlood Protein Electrophoresislanguage.human_languageGenetics PopulationPhenotypeEnglandGenesPhosphoglucomutaselanguagePhosphoglucomutaseFemaledescription
The placental phosphoglucomutase phenotypes controlled by the first locus of 235 German and 119 non-German samples were determined. Both in the pooled material and in the sample containing German subjects only there was a significant deviation from the expected Hardy-Weinberg equilibrium. A segregation analysis of 1174 families also revealed significant deviations in the phenotypes of the children, though the mating frequencies were as expected. The distribution of the children's phenotypes deviated significantly from Hardy-Weinberg equilibrium though this was not found in the parent samples. The results are discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1973-09-20 | Humangenetik |