Search results for "longevity."

Overexpression of Human and Fly Frataxins in Drosophila Provokes Deleterious Effects at Biochemical, Physiological and Developmental Levels

2011

10 pages, 5 figures. 21779322[PubMed] PMCID: PMC3136927

Effect of somatic cell count level on functional longevity in Valle del Belice dairy sheep assessed using survival analysis.

2009

The objectives of this study were to evaluate the effect of somatic cell count (SCC) on functional longevity and to estimate the heritability of functional longevity using survival analysis in Valle del Belice dairy sheep. A total of 4,880 lactations of 2,190 ewes from 11 flocks were used. In this study, SCC was considered as an indication of subclinical mastitis. In case of clinical cases, identified by the technicians at milking time, test-day weights and milk samples of those ewes were not considered. Somatic cells were analyzed as counts, without any transformation, and were grouped in 3 classes based on the observed SCC maximum (mxSCC). The mxSCC classes, expressed as 103 cells/mL, wer…

Does landscape diversity influence species fitness in farmland plants ?

2015

In agriculture, landscape management research has proven extremely valuable for explaining species amount, such as how species capture and utilize changed landscape resources to maintain population size and community diversity. What is surprising is the apparent lack of comparable studies on the effects of landscape properties and management on species fitness. Here, we search for "pathological" situations where landscape effects on farmland plant amount mask significantly different effects on fitness. We examined the case of 83 weed species in 256 fields distributed across the UK national scale. Whether at the local scale of the neighborhood or the larger scale of 2 km, we find landscape e…

Dormancy and longevity of soil-buried weed seeds : from examples to generalization

2012

EA SPE EcolDur GEAPSI CT3 CT1EA SPE EcolDur GEAPSI CT3 CT1; The main part of the life-cycle of weeds, especially in cultivated fields, is spent as seeds buried in the soil. Longevity and dormancy are two major traits driving weed survival and infestation in the framework of crop rotation and management. Modelling allows inference of these key processes from morpho-anatomical description of the seeds, thus avoiding long-term germination studies of buried seeds over the years. Two new sets of experimental data on two different weeds offer the opportunity to compare actual results to predicted values. This study deals with cornflower (Centaurea cyanus), a winter weed of cereals and oilseed rap…

Pentamidine rescues contractility and rhythmicity in a Drosophila model of myotonic dystrophy heart dysfunction

2015

Up to 80% of individuals with myotonic dystrophy type 1 (DM1) will develop cardiac abnormalities at some point during the progression of their disease, the most common of which is heart blockage of varying degrees. Such blockage is characterized by conduction defects and supraventricular and ventricular tachycardia, and carries a high risk of sudden cardiac death. Despite its importance, very few animal model studies have focused on the heart dysfunction in DM1. Here, we describe the characterization of the heart phenotype in a Drosophila model expressing pure expanded CUG repeats under the control of the cardiomyocyte-specific driver GMH5-Gal4. Morphologically, expression of 250 CUG repeat…

The Challenges in Moving from Ageing to Successful Longevity

2014

During the last decades survival has significantly improved and centenarians are becoming a fast-growing group of the population. Human life span is mainly dependent on environmental and genetic factors. Favourable modifications of lifestyle factors (e.g. physical activity, diet and not smoking) and healthcare (e.g. effective vascular disease prevention) have also increased human life span. Genetic factors contribute to the variation of human life span by around 25%, which is believed to be more profound after 85 years of age. It is likely that multiple factors influence life span and we need answers to questions such as: 1) What does it take to reach 100?, 2) Do centenarians have better he…

HEALTHY LONGEVITY THANKS TO THE MEDITERRANEAN DIET

2009

'Immunogenetics of Aging': report on the activities of the 15th International HLA and Immunogenetics Working Group and 15th International HLA and Imm…

2011

'Immunogenetics of Aging' is a component that was first included in the 14th International HLA and Immunogenetics Workshop (IHIWS) and developed further within the 15th Workshop. The aim of this component was to assess the impact of human leukocyte antigen (HLA) genes, cytokine genes, and some innate immunity genes such as killer-cell immunoglobulin-like receptors (KIRs) and mannose-binding lectin 2 (MBL2) in successful aging and their contribution to the better understanding of immune dysfunction in old age. Within the 15th IHIWS new populations were included in the analysis. Additional cytokine gene polymorphisms were assessed and innate immunity genes were analyzed for possible relevance…

2016 Antiaging Medicine

2016

• The factors best demonstrated to delay aging are fruit and vegetables, exercise, not smoking, drinking one or two glasses of alcohol daily, and fish consumption. • Vitamin D replacement, in persons with low 25[OH] vitamin D levels, decreases hip fractures, improves muscle strength, enhances function, and decreases mortality. • Antiaging medicine has been hijacked by charlatans who promote unproven or dangerous remedies to a naïve aging public. • Too often animal studies that produce longevity are directly ap-plied to humans before appropriate clinical trials have been carried out. • There is no evidence that hormones or megadoses of vitamins prolong life. • Numerous products of varying qu…

Drosophila melanogaster overexpression FAS live longer

2018

FAS and FAS ligand is critical in the control of the extension of extrinsic pathway of apoptosis. In previous studies we have performed transcriptomics peripheral blood cells from centenarians, octogenarians and young persons and we found over expression in centenarians of the FAS receptor. To confirm the role of FAS ligand in longevity across animal species, we have generated Drosophila melanogaster that over expresses this gene using the GAL4-UAS technique. The results show that flies overexpressing FAS increase maximal longevity in twelve percent and average longevity in six percent. Therefore, we confirm that FAS is related to longevity flight.