Search results for "loop"
showing 10 items of 608 documents
The COGNITION Study Rationale and Design: Influence of Closed Loop Stimulation on Cognitive Performance in Pacemaker Patients
2008
Background: Several studies showed the beneficial effect of pacemaker implantation on cognitive performance in patients with bradycardia. But it has never been investigated if patients with chronotropic incompetence may improve their cognitive performance if treated by a rate-adaptive system reacting to mental stress in comparison to the most frequently used accelerometer-driven pacing. Methods: The randomized, single-blind, multicenter COGNITION study evaluates if closed loop stimulation (CLS) offers incremental benefit in the speed of cognitive performance and the overall well-being of elderly patients with bradycardia compared with accelerometer-based pacing. Four hundred chronotropicall…
The influence of reverse flow on the dynamics of closed-loop supply chains
2014
The purpose of this paper is to study the impact of reverse logistics’ factors on the order and inventory variance amplification in a closed-loop supply chain. We adopt a difference equation math approach for analysing a closed-loop supply chain. Results show how the return flow positively affects both the inventory variance and the bullwhip effect independently of the number of echelons. On the contrary, an increasing remanufacturing lead-time negatively affects both the two metrics studied independently of the above mentioned settings. However, when the number of echelons increases, the benefit provided by the return flow tends to decrease.
Human-in-the-Loop Conversation Agent for Customer Service
2020
This paper describes a prototype system for partial automation of customer service operations of a mobile telecommunications operator with a human-in-the loop conversational agent. The agent consists of an intent detection system for identifying the types of customer requests that it can handle appropriately, a slot filling information extraction system that integrates with the customer service database for a rule-based treatment of the common scenarios, and a template-based language generation system that builds response candidates that can be approved or amended by customer service operators. The main focus of this paper is on the system architecture and machine learning system structure …
7C: Computational Chromosome Conformation Capture by Correlation of ChIP-seq at CTCF motifs.
2019
Abstract Background Knowledge of the three-dimensional structure of the genome is necessary to understand how gene expression is regulated. Recent experimental techniques such as Hi-C or ChIA-PET measure long-range chromatin interactions genome-wide but are experimentally elaborate, have limited resolution and such data is only available for a limited number of cell types and tissues. Results While ChIP-seq was not designed to detect chromatin interactions, the formaldehyde treatment in the ChIP-seq protocol cross-links proteins with each other and with DNA. Consequently, also regions that are not directly bound by the targeted TF but interact with the binding site via chromatin looping are…
Meox2/Tcf15 Heterodimers Program the Heart Capillary Endothelium for Cardiac Fatty Acid Uptake
2015
Background— Microvascular endothelium in different organs is specialized to fulfill the particular needs of parenchymal cells. However, specific information about heart capillary endothelial cells (ECs) is lacking. Methods and Results— Using microarray profiling on freshly isolated ECs from heart, brain, and liver, we revealed a genetic signature for microvascular heart ECs and identified Meox2/Tcf15 heterodimers as novel transcriptional determinants. This signature was largely shared with skeletal muscle and adipose tissue endothelium and was enriched in genes encoding fatty acid (FA) transport–related proteins. Using gain- and loss-of-function approaches, we showed that Meox2/Tcf15 media…
Spectral function for overoccupied gluodynamics from real-time lattice simulations
2018
We study the spectral properties of a highly occupied non-Abelian non-equilibrium plasma appearing ubiquitously in weak coupling descriptions of QCD matter. The spectral function of this far-from-equilibrium plasma is measured by employing linear response theory in classical-statistical real-time lattice Yang-Mills simulations. We establish the existence of transversely and longitudinally polarized quasiparticles and obtain their dispersion relations, effective mass, plasmon frequency, damping rate and further structures in the spectral and statistical functions. Our new method can be interpreted as a non-perturbative generalization of hard thermal loop (HTL) effective theory. We see indica…
The one loop gluon emission light cone wave function
2017
Light cone perturbation theory has become an essential tool to calculate cross sections for various small-$x$ dilute-dense processes such as deep inelastic scattering and forward proton-proton and proton-nucleus collisions. Here we set out to do one loop calculations in an explicit helicity basis in the four dimensional helicity scheme. As a first process we calculate light cone wave function for one gluon emission to one-loop order in Hamiltonian perturbation theory on the light front. We regulate ultraviolet divergences with transverse dimensional regularization and soft divergences with using a cut-off on longitudinal momentum. We show that when all the renormalization constants are comb…
Stability of charge-pump phase-locked loops : the hold-in and pull-in ranges
2020
The problem of design and analysis of synchronization control circuits is a challenging task for many applications: satellite navigation, digital communication, wireless networks, and others. In this article the Charge-Pump Phase-Locked Loop (CP-PLL) electronic circuit, which is used for frequency synthesis and clock generation in computer architectures, is studied. Analysis of CP-PLL is not trivial: full mathematical model, rigorous definitions, and analysis still remain open issues in many respects. This article is devoted to development of a mathematical model, taking into account engineering aspects of the circuit, interpretation of core engineering problems, definition in relation to m…
Nonlinear Analysis of Charge-Pump Phase-Locked Loop : The Hold-In and Pull-In Ranges
2021
In this paper a fairly complete mathematical model of CP-PLL, which reliable enough to serve as a tool for credible analysis of dynamical properties of these circuits, is studied. We refine relevant mathematical definitions of the hold-in and pull-in ranges related to the local and global stability. Stability analysis of the steady state for the charge-pump phase locked loop is non-trivial: straight-forward linearization of available CP-PLL models may lead to incorrect conclusions, because the system is not smooth near the steady state and may experience overload. In this work necessary details for local stability analysis are presented and the hold-in range is computed. An upper estimate o…
The role of hypoxia-induced factors in tumor progression.
2004
Abstract Learning Objectives After completing this course, the reader will be able to: Describe hypoxia-induced mechanisms for cell survival. Discuss hypoxia-induced gene expression. Relate hypoxia and glucose metabolism. Access and take the CME test online and receive 1 hour of AMA PRA category 1 credit atCME.TheOncologist.com Hypoxia is a common characteristic of locally advanced solid tumors that has been associated with diminished therapeutic response and, more recently, with malignant progression, that is, an increasing probability of recurrence, locoregional spread, and distant metastasis. Emerging evidence indicates that the effect of hypoxia on malignant progression is mediated by a…