Search results for "median"
showing 10 items of 337 documents
Allogeneic Stem Cell Transplant Versus Tandem High-Dose Melphalan for Front-Line Treatment of Deletion 13q14 Myeloma – An Interim Analysis of the Ger…
2009
Abstract Abstract 51 Background Allogeneic stem cell transplantation (allo SCT), a treatment modality based on transfer of immunocompetent donor lymphocytes offers curative potential to subjects with a variety of hematological cancers. In multiple myeloma (MM), high-dose melphalan followed by autologous stem cell transplantation (auto SCT) is adopted as a standard of care. However, it remains palliative since virtually all patients (pts) relapse and renders allo SCT an option of interest. Deletion of chromosome 13q14 (13q-) in MM has been shown to negatively impact prognosis. Therefore, improvement of therapy for 13q- pts is highly desirable. Patients and methods A prospective two-arm multi…
Adolescent use of social media and associations with sleep patterns across 18 European and North American countries
2023
Objective Over the past decade, concurrent with increasing social media use (SMU), there has been a shift toward poorer sleep among adolescents in many countries. The purpose of this study was to examine the cross-national associations between adolescent SMU and sleep patterns, by comparing 4 different categories of SMU (nonactive, active, intense, and problematic use). Design, setting, and participants Data were from 86,542 adolescents in 18 European and North American countries that participated in the 2017/18 Health Behaviour in School-aged study. Measurements Mixed-effects linear regression models were used to examine cross-national associations between 4 SMU categories and adolescent s…
Distritos industriales y renta económica: el efecto distrito – renta
2019
En el presente trabajo se expone una primera aproximación al efecto distrito desde la variable de la renta económica, lo que se ha denominado efecto distrito – renta. Esta aproximación al fenómeno distritural se realiza desde la perspectiva del desarrollo local neomarshalliano para enfatizar la centralidad del distrito industrial como fuente de interpretaciones propias sobre el cambio económico y sujeto activo del mismo. A nivel empírico se realiza una aproximación a la contrastación de la existencia o no de efecto distrito – renta en los distritos industriales españoles para el año 2013; estos datos son analizados a través de la comparativa de la renta total, per cápita y por ocupado expre…
ESTRUCTURAS ORGANIZATIVAS EN EMPRESAS DE INTERNACIONALIZACIÓN ACELERADA: EVIDENCIA EMPÍRICA
2014
Las pequeñas y medianas empresas internacionales pueden clasificarse en tradicionales, y empresas de internacionalización acelerada o born global. A pesar de que existe una variedad importante de investigaciones en el tema, ninguna ha establecido si existen diferencias entre la organización formal de una empresa de internacionalización acelerada y una empresa internacional tradicional. Mediante un estudio de casos a nivel comparativo, se establecen dos empresas internacionales tradicionales en la industria turística y de alimentos, y se analizan sus estructuras formales, con respecto a dos empresas en las mismas industrias con características de born global. Se determinan diferencias en los…
Abnormal Somatosensory Evoked Potentials Indicate Compressive Cervical Myelopathy in Mucopolysaccharidoses
2000
Compressive myelopathy at the cranio-cervical junction is a complication of mucopolysaccharidoses (MPS). To detect cervical myelopathy we recorded median and posterior tibial nerve SEPs in 15 patients aged 2.4 - 33.4 years (median 8.8 years) with MPS I-S (n = 3), MPS IVA (n = 8) and MPS VI (n = 4). In addition to the cortical waveforms we recorded the subcortical median nerve SEPs N13b and P13 generated near the cranio-cervical junction and the lemniscal P30 after posterior tibial nerve stimulation. MRI studies in 13 subjects revealed spinal cord compression at the cranio-cervical junction in 10 patients; 5 patients had an increased signal intensity on the T2-weighted initial MRI indicating…
Lesions of single nerves
2017
The trigeminal nerve exits the brain in its anatomical course in the area of the pons and proceeds to the anterior edge of the petrous bone. There, the nerve forms the trigeminal ganglion – also known as the Gasserian ganglion – which, sheathed by a dural sleeve, gives off three branches (V1–3).
Statistical power of disease cluster and clustering tests for rare diseases: A simulation study of point sources
2012
Abstract Two recent epidemiological studies on clustering of childhood leukemia showed different results on the statistical power of disease cluster and clustering tests, possibly an effect of spatial data aggregation. Eight different leukemia cluster scenarios were simulated using individual addresses of all 1,009,332 children living in Denmark in 2006. For each scenario, a number of point sources were defined with an increased risk ratio at centroid, decreasing linearly to 1.0 at the edge; aggregation levels were administrative units of Danish municipalities and squares of 5, 12.5 and 25 km 2 . Six statistical methods were compared. Generally, statistical power decreased with increasing s…
Impact of Pre-Transplant Ruxolitinib in Myelofibrosis Patients on Outcome after Allogeneic Stem Cell Transplantation
2016
Abstract Introduction Ruxolitinib is the first approved drug for treatment of myelofibrosis. Major effects are reduction in spleen size and improvement of constitutional symptoms. Because spleen size and constitutional symptoms may influence outcome after allogeneic stem cell transplantation (ASCT), ruxolitinib is recommended before stem cell transplantation in order to reduce therapy-related morbidity and mortality and improve outcome (EBMT/ELN recommendation, Leukemia 2015) The aim of this retrospective study was to evaluate the impact of pretreatment with ruxolitinib in comparison to transplantation of ruxolitinib-naïve MF patients with regard to outcome after ASCT. Patients and methods …
Leisure-time physical activity, sedentary behaviors, sleep, and cardiometabolic risk factors at baseline in the PREDIMED-PLUS intervention trial: A c…
2017
Limited data exists on the interrelationships between physical activity (PA), sedentary behaviors and sleep concerning cardiometabolic risk factors in aged adults at high cardiovascular disease risk. Our aim was to examine independent and joint associations between time spent in leisure-time PA, sedentary behaviors and sleep on the prevalence of obesity, type 2 diabetes (T2D) and components of the metabolic syndrome (MetS) in Mediterranean individuals at high cardiovascular risk. Cross-sectional analyses were performed on baseline data from 5776 Spanish adults (aged 55-75y in men; 60-75y in women) with overweight/ obesity and MetS, from October 2013 to October 2016, in the PREDIMED-PLUS tri…
Predictors of short- and long-term adherence with a Mediterranean-type diet intervention: the PREDIMED randomized trial.
2016
Background: Dietary intervention success requires strong participant adherence, but very few studies have examined factors related to both short-term and long-term adherence. A better understanding of predictors of adherence is necessary to improve the design and execution of dietary intervention trials. This study was designed to identify participant characteristics at baseline and study features that predict short-term and long-term adherence with interventions promoting the Mediterranean-type diet (MedDiet) in the PREvencion con DIeta MEDiterranea (PREDIMED) randomized trial. Methods: Analyses included men and women living in Spain aged 55-80 at high risk for cardiovascular disease. Part…